Cited by 175LGBTQ Health, Identity, and PolicyHormonal and reproductive studiesMenopause: Health Impacts and Treatments

Hormone therapy in transgender adults is safe with provider supervision; A review of hormone therapy sequelae for transgender individuals

Open access
Weinand, Jamie D., Safer, Joshua D.·2015·Journal of Clinical & Translational Endocrinology

Abstract

INTRODUCTION: Some providers report concern for the safety of transgender hormone therapy (HT). METHODS: This is a systematic literature review of HT safety for transgender adults. RESULTS: Current literature suggests HT is safe when followed carefully for certain risks. The greatest health concern for HT in transgender women is venous thromboembolism. HT among transgender men appears to cause polycythemia. Both groups experienced elevated fasting glucose. There is no increase in cancer prevalence or mortality due to transgender HT. CONCLUSION: Although current data support the safety of transgender HT with physician supervision, larger, long-term studies are needed in transgender medicine.

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Crossref · 10.1016/j.jcte.2015.02.003

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  • Gender-affirming hormone treatment significantly lowers testosterone levels in transgender women.

    “Since GAHT significantly lowers testosterone levels in transgender women,24 it is possible that they may experience reductions in HCT and Hgb, which would be anticipated to negatively affect endurance performance.”

    From How does hormone transition in transgender women change body composition, muscle strength and haemoglobin? Systematic review with a focus on the implications for sport participation (2021) · cites this paper as [24]

    The ‘Other considerations > Androgen deprivation in MTF individuals’ section describes androgen deprivation in transgender women, which supports the general direction of the claim. It does not report measured testosterone levels or establish that the reduction is statistically significant; no page number is available in our copy. (LLM, conf=0.75)

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Research works printed but not linked: 2

  1. [25]Gardner I. Safer J. Mok S. Weiss R. Kuohung W. “What is the effect of testosterone on the gene expression in the endometrium of transgender men? Oral Presentation at the World Professional Association for Transgender Health (WPATH) Graduate Student Research Symposium held at the 13th Annual Philadelphia Trans Health Conference, Philadelphia, PA June 2014
  2. [46]Roberts T. Kraft C. French D. Wuyang J. Wu A. Tangpricha V. Interpreting laboratory resutls in transgender patients on HRT Am J Med 127 2 2014 159 162 24332725

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Authors
Weinand, J. D., & Safer, J. D.
Affiliations
Boston University (US)
Corresponding author
Safer, Joshua D.
Venue
Journal of Clinical & Translational Endocrinology
Publisher
Elsevier BV
Published
2015-06
Volume
2
Issue
2
Pages
55-60
ISSN
2214-6237 (ISSN-L)
OpenAlex
W2073208821
Cited by
175
References
72
Citations by year
2026: 3 · 2025: 6 · 2024: 20 · 2023: 15 · 2022: 21 · 2021: 14 · 2020: 24 · 2019: 21 · 2018: 20 · 2017: 15 · 2016: 12 · 2015: 4
FWCI
27.89
Type
journal article
Language
en
Update notices
erratum (2024-03-01)
Open access
Locations
  • Journal of Clinical & Translational Endocrinology (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R13HD084267)
Topics
  • Social Sciences › Psychology › Social Psychology › LGBTQ Health, Identity, and Policy
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords
hormone therapy safety, transgender adults, venous thromboembolism, polycythemia, fasting blood glucose, cancer risk, cancer mortality, transgender women, transgender men

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