Thyroid hormone and recovery of cardiac function in patients with acute myocardial infarction: a strong association?
Abstract
OBJECTIVE: This study investigated whether changes in thyroid hormone (TH) in plasma are associated with the recovery of cardiac function in patients with acute myocardial infarction (AMI). Previous experimental studies have provided evidence of potential implication of TH signaling in post-ischemic recovery of cardiac function. METHODS: A total of 47 patients with AMI and early reperfusion therapy were included in this study. Myocardial injury was analyzed by peak creatinine kinase-MB (CKMB) and cardiac function was assessed by echocardiographic left ventricular ejection fraction (LVEF%). Recovery of function (ΔEF%) was estimated as the difference of LVEF% between 48 h and 6 months (6 mo) after AMI. Total triiodothyronine (T(3)), thyroxine (T(4)), and TSH were measured in plasma at different time points (24 h, 48 h, 5 d, and 6 mo). RESULTS: A significant correlation between LVEF% and T(3) (r=0.5, P=0.0004) was found early after AMI (48 h), whereas no correlation was observed between CKMB and T(3) (r=-0.04, P=0.81). A strong correlation was found between ΔEF% and total T(3) (r=0.64, P=10(-6)) at 6 mo after AMI. Furthermore, multivariate regression analysis revealed that T(3) at 6 mo (r=0.64, r(2)=0.41, P=10(-6)) was an independent determinant of ΔEF%. CONCLUSION: Changes in T(3) levels in plasma are closely correlated with the early and late recovery of cardiac function after AMI. T(3) levels at 6 mo appear to be an independent predictor of late functional recovery.
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T3 at 6 months was an independent predictor of changes in left ventricular ejection fraction between the early and follow-up periods.
“T 3 at 6 months was an independent predictor of LV ejection fraction changes between the early and follow-up periods (123).”
From Thyroid Hormones and Cardiovascular Function and Diseases (2018) · cites this paper as [123]
Lower T3 levels after acute myocardial infarction independently predict late recovery of left ventricular function after 6 months.
“lower T 3 levels after AMI are an independent predictor of late recovery of LV function after 6 months (123).”
From Thyroid Hormones and Cardiovascular Function and Diseases (2018) · cites this paper as [123]
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- Authors
- Lymvaios, I., Mourouzis, I., Cokkinos, D. V., Dimopoulos, M. A., Toumanidis, S. T., & Pantos, C.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- Academy of Athens (GR)
- Corresponding author
- Pantos, Constantinos
- ORCID
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-07
- Volume
- 165
- Issue
- 1
- Pages
- 107-114
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2153382168
- Cited by
- 87
- References
- 40
- Citations by year
- 2026: 1 · 2025: 5 · 2023: 6 · 2022: 5 · 2021: 2 · 2020: 11 · 2019: 6 · 2018: 11 · 2017: 4 · 2016: 7 · 2015: 8 · 2014: 6 · 2013: 9 · 2012: 3
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Keywords
- thyroid hormones, triiodothyronine, acute myocardial infarction, cardiac function recovery, left ventricular ejection fraction, creatine kinase-MB, thyroxine, thyroid-stimulating hormone, reperfusion therapy, prognostic factors
- MeSH terms
- Aged, Female, Humans, Male, Middle Aged, Myocardial Infarction, Thyroxine, Triiodothyronine, Myocardial Reperfusion, Ventricular Function, Left
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