CoChat
Sign Up
Cited by 192Heart Failure Treatment and ManagementThyroid Disorders and TreatmentsHormonal and reproductive studies

Triiodothyronine levels for risk stratification of patients with chronic heart failure

Open access
Pingitore, Alessandro, Landi, Patrizia, Taddei, Maria Chiara, Ripoli, Andrea, L’Abbate, Antonio, Iervasi, Giorgio·2005·The American Journal of Medicine
DOI 10.1016/j.amjmed.2004.07.052
Open this paper in CoChat — free accountOpen PDF

Abstract

Purpose We sought to explore the use of triiodothyronine (T(3)) concentrations as an adjunct to clinical and functional parameters when estimating prognosis in patients with chronic heart failure.Methods We enrolled 281 patients with postischemic (n = 153) or nonischemic (n = 128) dilated cardiomyopathy. Total and free T(3) concentrations, and traditional clinical and functional cardiac parameters, were measured 2 to 5 days after hospital admission. A multivariate model was utilized to predict all-cause and cardiac mortality.Results All-cause mortality was 23% (n = 64) after a mean (+/-SD) of 12 +/- 7 months of follow-up; 47 (73%) of the patients died from cardiac causes. The mean ejection fraction was lower in those patients who died than in those who survived (26% +/- 8% vs. 31% +/- 8%, P < 0.001), as were levels of total T(3) (1.0 +/- 0.4 nmol/L vs. 1.3 +/- 0.3 nmol/L, P < 0.001) and free T(3) (3.2 +/- 1.4 pmol/L vs. 3.7 +/- 1.0 pmol/L, P < 0.001). In a multivariate model, ejection fraction (odds ratio [OR] = 2.0 per 10% decrease; 95% confidence interval [CI]: 1.4 to 2.8 per 10% decrease; P < 0.001) and total T(3) level (OR = 0.3 per 1-nmol/L increase; 95% CI: 0.1 to 0.5 per 1-nmol/L increase; P < 0.001) were the only independent predictors of all-cause mortality. In an alternative model using free T(3) levels, ejection fraction (OR = 1.9; 95% CI: 1.4 to 2.7; P < 0.001) and free T(3) level (OR = 0.6 per 1 pmol/L; 95% CI: 0.5 to 0.8 per 1 pmol/L; P <0.02) were associated with all-cause mortality. When we considered cardiac mortality alone, male sex (OR = 3.5; 95% CI: 1.7 to 13; P < 0.04), ejection fraction (OR = 1.7; 95% CI: 1.2 to 2.5; P < 0.006), and total T(3) level (OR = 0.3; 95% CI: 0.2 to 0.7; P < 0.002) were independent predictors with the multivariate model.Conclusion Low T(3) levels are an independent predictor of mortality in patients with chronic heart failure, adding prognostic information to conventional clinical and functional cardiac parameters.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.amjmed.2004.07.052

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Patients with reduced left ventricular ejection fraction and low triiodothyronine have higher mortality than patients with similar left ventricular ejection fractions but normal triiodothyronine.

    “In particular, patients with reduced LV ejection fraction and low T 3 have higher mortality than patients with similar LV ejection fractions, but normal T 3 (134).”

    From Thyroid Hormones and Cardiovascular Function and Diseases (2018) · cites this paper as [134]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 3

  1. Klein I, Ojamaa K. Thyroid hormone treatment of congestive heart failure. Am J Cardiol. 1998;81:490 -491.
  2. Di Pierro FV, Bavaria JE, Lankford EB, et al. Improved cardiac output and enhanced cardiac mechanical efficiency with acute administration of T3. Ann Thorac Surg. 1996;62:662-669.
  3. Ghione S, Del Chicca MG, Gazzetti P, Zucchelli GC. Circulating cathecolamines: a reapproisal. Intern Med. 1997;5:93-100.

Cited by

Sorted by citations

Related

Authors
Pingitore, A., Landi, P., Taddei, M. C., Ripoli, A., L’Abbate, A., & Iervasi, G.
Affiliations
  • Istituto di Fisiologia Clinica (IT)
  • Scuola Superiore Sant'Anna (IT)
Corresponding author
Pingitore, Alessandro
ORCID
Venue
The American Journal of Medicine
Publisher
Elsevier BV
Published
2005-02
Volume
118
Issue
2
Pages
132-136
ISSN
0002-9343 (ISSN-L)
DOI
10.1016/j.amjmed.2004.07.052
OpenAlex
W2171564744
Cited by
192
References
25
Citations by year
2026: 2 · 2025: 1 · 2024: 6 · 2023: 9 · 2022: 5 · 2021: 9 · 2020: 12 · 2019: 11 · 2018: 9 · 2017: 10 · 2016: 10 · 2015: 10 · 2014: 6 · 2013: 9 · 2012: 9
FWCI
7.21
Type
journal article
Language
en
Open access
Licence
Locations
  • The American Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutional Research Information System (Sant'Anna School of Advanced Studies) (submittedVersion, other-oa)
  • JAMA
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
triiodothyronine, free triiodothyronine, chronic heart failure, dilated cardiomyopathy, risk stratification, prognosis, all-cause mortality, cardiac mortality, ejection fraction, thyroid hormones, non-ischemic cardiomyopathy, prognostic factors, multivariate risk models, NYHA functional class, NT-proBNP
MeSH terms
Aged, Aged, 80 and over, Chronic Disease, Female, Heart Failure, Humans, Male, Middle Aged, Prognosis, Stroke Volume, Triiodothyronine, Biomarkers, Multivariate Analysis, Survival Analysis, Myocardial Ischemia, Risk Assessment

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review