The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.
Fertility, sexuality and testicular adrenal rest tumors in adult males with congenital adrenal hyperplasia
Open accessAbstract
Objective: Fertility in males with congenital adrenal hyperplasia (CAH) is reported from normal to severely impaired. Therefore, we investigated fertility/fecundity, social/sexual situation, and pituitary–gonadal function in CAH males. Subjects and methods: The patient cohort comprised 30 males, aged 19–67 years, with 21-hydroxylase deficiency. Their fertility was compared with age-matched national population data. For the evaluation of social/sexual factors and hormone status, age-matched controls were recruited ( n =32). Subgroups of different ages (<30 years and older) and CYP21A2 genotypes (null (severe salt-wasting (SW)), I2splice (milder SW), and I172N (simple virilizing)) were also studied. Patients underwent testicular ultrasound examination ( n =21) and semen analysis ( n =14). Results: Fertility was impaired in CAH males compared with national data (0.9±1.3 vs 1.8±0.5 children/father, P <0.001). There were no major differences in social and sexual factors between patients and controls apart from more fecundity problems, particularly in the I172N group. The patients had lower testosterone/estradiol (E 2 ) ratio and inhibin B, and higher FSH. The semen samples were pathological in 43% (6/14) of patients and sperm concentration correlated with inhibin B and FSH. Testicular adrenal rest tumors (TARTs) were found in 86% (18/21). Functional testicular volume correlated positively with the testosterone/E 2 ratio, sperm concentration, and inhibin B. Patients with pathological semen had increased fat mass and indications of increased cardiometabolic risk. Conclusions: Fertility/fecundity was impaired in CAH males. The frequent occurrence of TARTs resulting in testicular insufficiency appears to be the major cause, but other factors such as elevated fat mass may contribute to a low semen quality.
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In the citing paper
“One randomized study in 30 women with NC CAH found cyproterone acetate to be more effective than hydrocortisone for isolated hirsutism (435).”
From Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management (2022) · cites this paper as [435]
Experimental — accuracy not yet measuredIn the citing paper
“The prevalence of TART is between 44-94% of men 98,107,114,115”
From Congenital adrenal hyperplasia (2017) · cites this paper as [115]
In the citing paper
“Fertility in males with CAH is often impaired (226, 237, 248-250).”
From Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society* Clinical Practice Guideline (2018) · cites this paper as [237]
In the citing paper
“Available data indicate that TARTs in men with NCCAH are extremely rare (237); consequently, prophylactic GCs do not seem to be warranted in these men.”
From Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society* Clinical Practice Guideline (2018) · cites this paper as [237]
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Citations
Cites
A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum
Vermeulen, A., Verdonck, L., & Kaufman, J. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6079 · Cited by 3,824
Health status of adults with congenital adrenal hyperplasia: a cohort study of 203 patients
Arlt, W., Willis, D. S., Wild, S. H., Krone, N., Doherty, E. J., Hahner, S., Han, T. S., Carroll, P. V., Conway, G. S., Rees, D. A., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0917 · Cited by 506
Male obesity and alteration in sperm parameters
Hammoud, A. O., Wilde, N., Gibson, M., Parks, A. L., Carrell, D. T., & Meikle, A. W. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.10.011 · Cited by 480
Hines, M., Brook, C. G. D., & Conway, G. S. (2004) · The Journal of Sex Research · doi:10.1080/00224490409552215 · Cited by 445
The effect of obesity on sperm disorders and male infertility
du Plessis, S. S., Cabler, S., McAlister, D. A., Sabanegh, E., & Agarwal, A. K. (2010) · Nature Reviews Urology · doi:10.1038/nrurol.2010.6 · Cited by 421
The Metabolic Syndrome and Male Infertility
Kasturi, S. S., Tannir, J. R., & Brannigan, R. E. (2008) · Journal of Andrology · doi:10.2164/jandrol.107.003731 · Cited by 306
Stikkelbroeck, N. M. M. L., Otten, B. J., Pasic, A., Jager, G. J., Sweep, C. G. J. F., Noordam, K., & Hermus, A. R. M. M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8090 · Cited by 305
Frisén, L., Nordenström, A., Falhammar, H., Filipsson, H., Holmdahl, G., Janson, P. O., Thorén, M., Hagenfeldt, K., Möller, A., & Nordenskjöld, A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0636 · Cited by 276
Self-citationLong Term Outcome in Adult Males with Classic Congenital Adrenal Hyperplasia
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Self-citation
Research works printed but not linked: 3
- Cabrera, 2001, Journal of Clinical Endocrinology & Metabolism, 86, 3070, 10.1210/jc.86.7.3070 · DOI
- Stikkelbroeck, 2001, Journal of Clinical Endocrinology & Metabolism, 86, 5721, 10.1210/jc.86.12.5721 · DOI · Paper page
- Vermeulen, 1999, Journal of Clinical Endocrinology & Metabolism, 84, 3666, 10.1210/jc.84.10.3666 · DOI · Paper page
Cited by
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Speiser, P. W., Azziz, R., Baskin, L. S., Ghizzoni, L., Hensle, T. W., Merke, D. P., Meyer-Bahlburg, H. F. L., Miller, W. L., Montori, V. M., Oberfield, S. E., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2631 · Cited by 1,468
Speiser, P. W., Arlt, W., Auchus, R. J., Baskin, L. S., Conway, G. S., Merke, D. P., Meyer-Bahlburg, H. F. L., Miller, W. L., Murad, M. H., Oberfield, S. E., et al. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01865 · Cited by 1,234
Congenital adrenal hyperplasia
El-Maouche, D., Arlt, W., & Merke, D. P. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31431-9 · Cited by 669
Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management
Claahsen - van der Grinten, H. L., Speiser, P. W., Ahmed, S. F., Arlt, W., Auchus, R. J., Falhammar, H., Flück, C. E., Guasti, L., Huebner, A., Kortmann, B. B. M., et al. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnab016 · Cited by 556
Self-citationCarmina, E., Dewailly, D., Escobar-Morreale, H. F., Keleştimur, F., Morán, C., Oberfield, S. E., Witchel, S. F., & Azziz, R. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmx014 · Cited by 206
Metadata
- Authors
- Falhammar, H., Nyström, H. F., Ekström, U., Granberg, S., Wedell, A., & Thorén, M.
- Affiliations
- Karolinska University Hospital (SE)
- Sahlgrenska University Hospital (SE)
- Corresponding author
- Falhammar, Henrik
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-03
- Volume
- 166
- Issue
- 3
- Pages
- 441-449
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- PMC
- PMC3290120
- OpenAlex
- W2146885061
- Cited by
- 170
- References
- 33
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 8 · 2023: 13 · 2022: 10 · 2021: 11 · 2020: 12 · 2019: 15 · 2018: 16 · 2017: 12 · 2016: 10 · 2015: 14 · 2014: 10 · 2013: 14 · 2012: 9
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- European Journal of Endocrinology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Karolinska Institutet
- Stockholms Läns Landsting
- Vetenskapsrådet (12198)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- congenital adrenal hyperplasia, 21-hydroxylase deficiency, male fertility, fecundity, testicular adrenal rest tumor, testicular insufficiency, semen quality, testosterone/estradiol ratio, inhibin B, follicle-stimulating hormone, salt-wasting phenotype, fat mass, cardiometabolic risk, pituitary-gonadal function
- MeSH terms
- Adrenal Hyperplasia, Congenital, Adrenal Rest Tumor, Adult, Age Factors, Aged, Humans, Infertility, Male, Male, Middle Aged, Registries, Ultrasonography, 3-Hydroxysteroid Dehydrogenases, Cohort Studies, Case-Control Studies, Sexuality
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