The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
MECHANISMS IN ENDOCRINOLOGY: Vitamin D and fertility: a systematic review
Abstract
BACKGROUND: Vitamin D has been well-known for its function in maintaining calcium and phosphorus homeostasis and promoting bone mineralization. There is some evidence that in addition to sex steroid hormones, the classic regulators of human reproduction, vitamin D also modulates reproductive processes in women and men. AIM: The aim of this review was to assess the studies that evaluated the relationship between vitamin D and fertility in women and men as well as in animals. METHODS: We performed a systematic literature search in Pubmed for relevant English language publications published until October 2011. RESULTS AND DISCUSSION: The vitamin D receptor (VDR) and vitamin D metabolizing enzymes are found in reproductive tissues of women and men. Vdr knockout mice have significant gonadal insufficiency, decreased sperm count and motility, and histological abnormalities of testis, ovary and uterus. Moreover, we present evidence that vitamin D is involved in female reproduction including IVF outcome (clinical pregnancy rates) and polycystic ovary syndrome (PCOS). In PCOS women, low 25-hydroxyvitamin D (25(OH)D) levels are associated with obesity, metabolic, and endocrine disturbances and vitamin D supplementation might improve menstrual frequency and metabolic disturbances in those women. Moreover, vitamin D might influence steroidogenesis of sex hormones (estradiol and progesterone) in healthy women and high 25(OH)D levels might be associated with endometriosis. In men, vitamin D is positively associated with semen quality and androgen status. Moreover, vitamin D treatment might increase testosterone levels. Testiculopathic men show low CYP21R expression, low 25(OH)D levels, and osteoporosis despite normal testosterone levels.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Holick, M. F. (2007) · New England Journal of Medicine · doi:10.1056/nejmra070553 · Cited by 13,720
Holick, M. F., Binkley, N. C., Bischoff-Ferrari, H. A., Gordon, C. M., Hanley, D. A., Heaney, R. P., Murad, M. H., & Weaver, C. M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0385 · Cited by 10,538
Inflammation and insulin resistance
Shoelson, S. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29069 · Cited by 4,769
Ross, A. C., Manson, J. E., Abrams, S. A., Aloia, J. F., Brannon, P. M., Clinton, S. K., Durazo-Arvizu, R. A., Gallagher, J. C., Gallo, R. L., Jones, G., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2704 · Cited by 4,026
Decreased bioavailability of vitamin D in obesity
Wortsman, J., Matsuoka, L. Y., Chen, T. C., Lu, Z., & Holick, M. F. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.3.690 · Cited by 3,204
Systematic review and meta-analysis
(2019) · Providing Information for Health · doi:10.1201/9781315377315-19 · Cited by 2,659
Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis*
Dunaif, A. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.6.0318 · Cited by 2,458
The Role of Vitamin D and Calcium in Type 2 Diabetes. A Systematic Review and Meta-Analysis
Pittas, A. G., Lau, J., Hu, F. B., & Dawson-Hughes, B. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0298 · Cited by 2,001
Ehrmann, D. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmra041536 · Cited by 1,881
Obesity, Inflammation, and Insulin Resistance
Shoelson, S. E., Herrero, L., & Naaz, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.059 · Cited by 1,806
Research works printed but not linked: 18
- Thonneau, 1991, Human Reproduction, 6, 811, 10.1093/humrep/ · doi:10.1093/humrep/
- Forti, 1998, Journal of Clinical Endocrinology & Metabolism, 83, 4177, 10.1210/jc.83.12.4177 · doi:10.1210/jc.83.12.4177
- Sun, 1998, Endocrinology, 139, 1684, 10.1210/en.139.4.1684 · doi:10.1210/en.139.4.1684
- Stephanou, 1994, Endocrinology, 135, 2651, 10.1210/en.135.6.2651 · DOI
- 2009, 74, 264
- 1992, American Journal of Physiology -- Legacy Content, 262, E884
- Horii, 1992, The Journal of toxicological sciences, 17, 91, 10.2131/jts.17.91 · doi:10.2131/jts.17.91
- 1989, American Journal of Physiology -- Legacy Content, 256, E483
- Rojansky, 1992, Human Reproduction, 7, 735, 10.1093/humrep/ · doi:10.1093/humrep/
- Rojansky, 2000, Fertility and sterility, 74, 476, 10.1016/S0015-0282(00)00669-5 · doi:10.1016/s0015-0282(00)00669-5
- 2009, Fertility and sterility, 94, 1314
- 2007, 132, 2169
- 2011, Journal of Clinical Endocrinology & Metabolism, 96, 3494
- 1999, 64, 430
- Wehr, 2011, Journal of endocrinological investigation, 34, 757
- 2008, POSTEPY HIGIENY I MEDYCYNY DDOSWIADCZALNEJ, 62, 103
- 2009, IDRUGS THE INVESTIGATIONAL DRUGS JOURNAL, 12, 2040
- Turton, 1977, Lancet, 1, 222, 10.1016/S0140-6736(77)91017-0 · doi:10.1016/s0140-6736(77)91017-0
Cited by
Pludowski, P., Holick, M. F., Pilz, S., Wagner, C. L., Hollis, B. W., Grant, W. B., Shoenfeld, Y., Lerchbaum, E., Llewellyn, D. J., Kienreich, K., et al. (2013) · Autoimmunity Reviews · doi:10.1016/j.autrev.2013.02.004 · Cited by 836
Self-citationVitamin D: Before, during and after Pregnancy: Effect on Neonates and Children
Mansur, J. L., Oliveri, B., Giacoia, E., Fusaro, D., & Costanzo, P. R. (2022) · Nutrients · doi:10.3390/nu14091900 · Cited by 185
Vitamin D and chronic diseases: the current state of the art
Muscogiuri, G., Altieri, B., Annweiler, C., Balercia, G., Pal, H. B., Boucher, B. J., Cannell, J. J., Foresta, C., Grübler, M. R., Kotsa, K., et al. (2017) · Archives of Toxicology · doi:10.1007/s00204-016-1804-x · Cited by 151
Shedding new light on female fertility: the role of vitamin D
Muscogiuri, G., Altieri, B., de Angelis, C., Palomba, S., Pivonello, R., Colao, A., & Orio, F. (2017) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-017-9407-2 · Cited by 142
Canguven, O., Talib, R. A., El Ansari, W., Yassin, D.-J., & Al Naimi, A. (2017) · The Aging Male · doi:10.1080/13685538.2016.1271783 · Cited by 112
Metadata
- Authors
- Lerchbaum, E., & Obermayer-Pietsch, B.
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-01-24
- Volume
- 166
- Issue
- 5
- Pages
- 765-778
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2006439158
- Cited by
- 408
- References
- 135
- FWCI
- 3.66
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: MECHANISMS IN ENDOCRINOLOGY: Vitamin D and fertility: a systematic review. https://app.cochat.ai/papers/10.1530/eje-11-0984
- The paper
- Lerchbaum, E., & Obermayer-Pietsch, B. (2012). MECHANISMS IN ENDOCRINOLOGY: Vitamin D and fertility: a systematic review. European Journal of Endocrinology. https://doi.org/10.1530/eje-11-0984
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
