Vitamin D: Before, during and after Pregnancy: Effect on Neonates and Children
Open accessAbstract
A worldwide high prevalence of vitamin D (VD) deficiency has become of growing concern because of potential adverse effects on human health, including pregnant women and their offsprings. Beyond its classical function as a regulator of calcium and phosphate metabolism, together with its fundamental role in bone health in every stage of life, its deficiency has been associated to multiple adverse health effects. The classic effects of VD deficiency in pregnancy and neonates have been late hypocalcemia and nutritional rickets. Nevertheless, recent studies have linked VD to fertility and 25(OH)D with several clinical conditions in pregnancy: preeclampsia, gestational diabetes, higher incidence of cesarean section and preterm birth, while in infants, the clinical conditions are low birth weight, lower bone mass and possible relationship with the development of such diseases as bronchiolitis, asthma, type 1 diabetes, multiple sclerosis and autism included as VD non-classical actions. The supplementation with Vitamin D and achievement of optimal levels reduce maternal-fetal and newborn complications. Supplementation in children with VD deficiency reduces the risk of respiratory infections and possibly autoimmune diseases and autism. This review emphasizes the roles of Vitamin D deficiency and the consequences of intervention from preconception to infancy.
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Vitamin D deficiency may be associated with an increased risk of GDM.
“Vitamin D deficiency may also be associated with an increased risk of GDM [133].”
From Medical Nutrition Therapy for Women with Gestational Diabetes: Current Practice and Future Perspectives (2025) · cites this paper as [133]
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- Authors
- Mansur, J. L., Oliveri, B., Giacoia, E., Fusaro, D., & Costanzo, P. R.
- Affiliations
- Endocrinology and Metabolism Center, La Plata B1902ADQ, Argentina
- Universidad de Buenos Aires (AR)
- Buenos Aires Gynecological Institute ACOG, Service Fundación Favaloro, Buenos Aires C1053ABH, Argentina
- Hospital Italiano de Buenos Aires (AR)
- Corresponding author
- Mansur, José Luis
- Costanzo, Pablo René
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2022-05-01
- Volume
- 14
- Issue
- 9
- Pages
- 1900
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC9105305
- OpenAlex
- W4225265692
- Cited by
- 185
- References
- 162
- Citations by year
- 2026: 33 · 2025: 57 · 2024: 54 · 2023: 30 · 2022: 10
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin K Research Studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- vitamin D deficiency, pregnancy, neonates, children, vitamin D supplementation, 25-hydroxyvitamin D, preeclampsia, gestational diabetes mellitus, cesarean section, preterm birth, low birth weight, bone mass, respiratory infections, autoimmune disease, autism spectrum disorder, asthma, type 1 diabetes, multiple sclerosis, fertility, maternal and fetal complications
- MeSH terms
- Cesarean Section, Child, Female, Humans, Infant, Infant, Low Birth Weight, Infant, Newborn, Pregnancy, Pregnancy Complications, Vitamin D, Vitamin D Deficiency, Vitamins, Dietary Supplements, Premature Birth
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