The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Hospital admission for diabetic ketoacidosis or severe hypoglycemia in 31,330 young patients with type 1 diabetes
Abstract
Objective: To investigate rates and risk factors of hospital admission for diabetic ketoacidosis (DKA) or severe hypoglycemia in young patients with established type 1 diabetes. Design: In total, 31 330 patients with type 1 diabetes (median age 12.7 years) from the Diabetes Patienten Verlaufsdokumentation (DPV) Prospective Diabetes Registry treated between 2011 and 2013 in Germany were included. Methods: Admission rates for DKA (pH <7.3 or bicarbonate <15 mmol/l) and severe hypoglycemia (requiring assistance from another person) were calculated by negative binomial regression analysis. Associations of DKA or hypoglycemia with patient and treatment characteristics were assessed by multivariable regression analysis. Results: The mean admission rate for DKA was 4.81/100 patient-years (95% CI, 4.51–5.14). The highest DKA rates were observed in patients with HbA1c ≥9.0% (15.83 (14.44–17.36)), age 15–20 years (6.21 (5.61–6.88)) and diabetes duration of 2–4.9 years (5.60 (5.00–6.27)). DKA rate was higher in girls than in boys (5.35 (4.88–5.86) vs 4.34 (3.95–4.77), P=0.002), and more frequent in migrants than in non-migrants (5.65 (4.92–6.49) vs 4.57 (4.23–4.93), P=0.008). The mean admission rate for severe hypoglycemia was 1.45/100 patient-years (1.30–1.61). Rates were higher in migrants compared to non-migrants (2.13 (1.72–2.65) vs 1.28 (1.12–1.47), P<0.001), and highest in individuals with severe hypoglycemia within the preceding year (17.69 (15.63–20.03) vs patients without preceding hypoglycemia 0.42 (0.35–0.52), P<0.001). Differences remained significant after multivariable adjustment. Conclusions: The identification of at-risk individuals for DKA (patients with high HbA1c, longer diabetes duration, adolescents, girls) and for severe hypoglycemia (patients with preceding severe hypoglycemia, migrants) may facilitate targeted diabetes counselling in order to prevent these complications.
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In the citing paper
“hypoglycaemic events leading to loss of consciousness or seizure occur at a rate of 2–8 per 100 person-years.103–105”
From Type 1 diabetes (2018) · cites this paper as [105]
In the citing paper
“Treatment in hospital for diabetic ketoacidosis occurs at a rate of 1–10 per 100 patient-years in paediatric populations with established type 1 diabetes,”
From Type 1 diabetes (2018) · cites this paper as [105]
In the citing paper
“Severe hypoglycaemic events requiring treatment assistance from another person occur at rates of 16–20 per 100 person-years;”
From Type 1 diabetes (2018) · cites this paper as [105]
Citations
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Diabetic ketoacidosis and hyperglycemic hyperosmolar state
Wolfsdorf, J. I., Allgrove, J., Craig, M. E., Edge, J., Glaser, N. S., Jain, V., Lee, W. W., Mungai, L., Rosenbloom, A. L., Sperling, M. A., et al. (2014) · Pediatric Diabetes · doi:10.1111/pedi.12165 · Cited by 369
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Self-citationCengiz, E., Xing, D., Wong, J. C., Wolfsdorf, J. I., Haymond, M. W., Rewers, A., Shanmugham, S., Tamborlane, W. V., Willi, S. M., Seiple, D. L., et al. (2013) · Pediatric Diabetes · doi:10.1111/pedi.12030 · Cited by 243
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Self-citationAssessment and management of hypoglycemia in children and adolescents with diabetes
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DiMeglio, L. A., Evans-Molina, C., & Oram, R. A. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31320-5 · Cited by 1,561
Karges, B., Schwandt, A., Heidtmann, B., Kordonouri, O., Binder, E., Schierloh, U., Boettcher, C., Kapellen, T., Rosenbauer, J., & Holl, R. W. (2017) · JAMA · doi:10.1001/jama.2017.13994 · Cited by 452
Self-citationHandelsman, Y., Henry, R. R., Bloomgarden, Z. T., Dagogo-Jack, S., DeFronzo, R. A., Einhorn, D., Ferrannini, E., Fonseca, V. A., Garber, A. J., Grunberger, G., et al. (2016) · Endocrine Practice · doi:10.4158/ep161292.ps · Cited by 358
Management of Hyperglycemic Crises
Fayfman, M., Pasquel, F. J., & Umpierrez, G. E. (2017) · Medical Clinics of North America · doi:10.1016/j.mcna.2016.12.011 · Cited by 312
Ehrmann, D., Kulzer, B., Roos, T., Haak, T., Al-Khatib, M., & Hermanns, N. (2020) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(20)30042-5 · Cited by 141
Metadata
- Authors
- Karges, B., Rosenbauer, J., Holterhus, P.-M., Beyer, P., Seithe, H., Vogel, C., Böckmann, A., Peters, D., Müther, S., Neu, A., Holl, R. W., & _, _.
- Affiliations
- Christian-Albrechts-Universität zu Kiel (DE)
- Universität Ulm (DE)
- Corresponding author
- Karges, Beate
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-09
- Volume
- 173
- Issue
- 3
- Pages
- 341-350
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W1831848670
- Cited by
- 129
- References
- 20
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 8 · 2023: 9 · 2022: 10 · 2021: 16 · 2020: 16 · 2019: 16 · 2018: 13 · 2017: 12 · 2016: 6 · 2015: 2
- FWCI
- 9.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Site cant be reached (submittedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- diabetic ketoacidosis, severe hypoglycemia, type 1 diabetes, young patients, hospitalization rates, risk factors, HbA1c, diabetes duration, sex differences, migrants, glycemic control, diabetes complications, Germany, children and adolescents, oral antidiabetic drugs
- MeSH terms
- Adolescent, Child, Child, Preschool, Diabetes Mellitus, Type 1, Female, Germany, Hospitalization, Humans, Hypoglycemia, Infant, Male, Regression Analysis, Risk Factors, Severity of Illness Index, Sex Factors, Transients and Migrants, Multivariate Analysis, Diabetic Ketoacidosis, Young Adult
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