Body composition and energy expenditure in thyroidectomized patients during short-term hypothyroidism and thyrotropin-suppressive thyroxine therapy
Abstract
Wolf M, Weigert A, Kreymann G. Body composition and energy expenditure in thyroidectomized patients during short-term hypothyroidism and thyrotropin-suppressive thyroxine therapy. Eur J Endocrinol 1996;134:168–73. ISSN 0804–4643 Thyroid hormone levels are a major determinant of energy balance and are thought to modify body composition by their effects on metabolism of lipids, carbohydrate and protein. The present study evaluates changes of body composition and basal energy expenditure (BEE) in thyroidectomized patients studied during short-term profound hypothyroidism while off all thyroid hormone before diagnostic whole-body I-imaging and while on thyrotrophin-suppressive thyroxine therapy. Basal energy expenditure was assessed by indirect calorimetry, and four-point body impedance analysis was used to estimate body composition. Patients were compared with healthy controls matched with respect to sex, age, height and weight. Compared to healthy controls the percentages of body water and body cell mass were significantly lower while the percentage of fat was significantly higher in patients during short-term hypothyroidism. Weight did not change significantly when patients were put on thyroxine treatment, but body fat (–0.95 ± 2.25 kg, p < 0.01) decreased while body water (+0.94 ± 1.31 kg, p < 0.01) and body cell mass (+0.9 ± 2.5 kg, p < 0.05) increased. With thyroxine replacement, body composition was not significantly different between patients and controls. Compared to healthy controls, BEE was significantly lower in patients without thyroxine replacement (5265 ± 766 kJ/24 h vs 6362 ± 992 kJ/24 h; p < 0.001). With thyroxine treatment, BEE increased (6492 ± 967 kJ/24 h) but was not significantly different from the controls (p 0.05). Neither body composition nor BEE was significantly different in a subgroup of thyroxine-treated patients with free triiodothyronine or thyroxine values above the normal range. In conclusion, both body composition and energy expenditure showed significant changes when patients were deprived of thyroid hormone. However, no evidence of excess metabolic effects of thyroid hormone during thyrotrophin-suppressive thyroxine therapy was found. Matthias Wolf, Medizinische Kern- und Poliklinik, Universitäts-Krankenhaus Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
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Prior long-term LT4 suppression studies did not find significant changes in resting energy expenditure, but some demonstrated effects on body weight or composition.
“While significant changes in resting energy expenditure (REE) were not found, some did demonstrate effects on body weight or composition.”
From Effects of levothyroxine replacement or suppressive therapy on energy expenditure and body composition (2016) · cites this paper as [12]
Only a handful of studies have reported the metabolic effects of long-term LT4 suppression therapy.
“Only a handful of studies have reported the metabolic effects of long-term LT4 suppression therapy (8-12).”
From Effects of levothyroxine replacement or suppressive therapy on energy expenditure and body composition (2016) · cites this paper as [12]
None of the prior long-term LT4 suppression studies investigated other components of energy balance, including food intake, physical activity, or the thermic effect of food.
“None investigated other components of energy balance, including food intake, physical activity, or the thermic effect of food (TEF).”
From Effects of levothyroxine replacement or suppressive therapy on energy expenditure and body composition (2016) · cites this paper as [12]
One study found no differences in REE or body composition compared to healthy controls in DTC patients treated with suppressive LT4.
“One study found no differences in REE or body composition compared to healthy controls (12)”
From Effects of levothyroxine replacement or suppressive therapy on energy expenditure and body composition (2016) · cites this paper as [12]
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- Authors
- Wolf, M., Weigert, A., & Kreymann, G.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- Corresponding author
- Wolf, Matthias
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-02
- Volume
- 134
- Issue
- 2
- Pages
- 168-173
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2036487918
- Cited by
- 69
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 4 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 5 · 2013: 1 · 2012: 2
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- thyroidectomy, hypothyroidism, basal energy expenditure, body composition, total body water, body cell mass, fat mass
- MeSH terms
- Adult, Aged, Body Composition, Energy Metabolism, Female, Humans, Hypothyroidism, Male, Middle Aged, Thyroid Neoplasms, Thyroidectomy, Thyrotropin, Thyroxine, Triiodothyronine
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