The DOI matches its Crossref record.
Gender differences in secretory activity of the human somatotropic (growth hormone) axis
Abstract
Major gender differences exist in the prevalence and severity of various disease states, rates of organ-specific aging and drug and hormone metabolism. Increased understanding of the mechanistic bases for these important sex differences is likely to stimulate new prognostic, therapeutic and diagnostic insights over many succeeding decades. I will outline clinical data that bear on regulatory mechanisms that give rise to sex-based differences in the neuroendocrine activity of the human somatotropic (GH) axis. Such studies have important implications in both pubertal and gonadoprival states, such as aging and the menopause, when the sex-steroid milieu changes dramatically.
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“The proposal that the sex difference in muscle mass and function might be due to sex differences in endogenous GH secretion (116) is refuted by the extensive and conclusive clinical evidence that endogenous GH secretion in young women is consistently higher (typically twice as high) as in young men of similar age (163–170).”
From Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance (2018) · cites this paper as [165]
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Items 101–102 of 102
Exercise and Growth Hormone Secretion
Veldhuis, J. D., & WELTMAN, A. L. (2001) · Endocrine updates · doi:10.1007/978-1-4615-1579-1_13
Self-citationMedic Spahic, J., Ricci, F., Aung, N., Hallengren, E., Axelsson, J., Hamrefors, V., Melander, O., Sutton, R., & Fedorowski, A. (2020) · Figshare · doi:10.6084/m9.figshare.12177873
Metadata
- Authors
- Veldhuis, J. D.
- Affiliations
- University of Virginia (US)
- Corresponding author
- Veldhuis, Johannes D
- ORCID
- Veldhuis, Johannes D
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-03
- Volume
- 134
- Issue
- 3
- Pages
- 287-295
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2136396730
- Cited by
- 102
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2020: 3 · 2018: 1 · 2016: 1 · 2015: 1 · 2013: 4 · 2012: 1
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- California HIV/AIDS Research Program
- National Institutes of Health (5k04hd000634-02, 5p30dk038942-05)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 38942)
- National Center for Research Resources (RR 00847, M01RR000847)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (1-K04-HD-00634)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Keywords
- sex differences, growth hormone, somatotropic axis, neuroendocrine regulation, puberty, gonadectomy, aging, menopause, sex steroids, hormone secretion
- MeSH terms
- Female, Humans, Kinetics, Male, Menstrual Cycle, Neurosecretory Systems, Pulsatile Flow, Sex Characteristics, Growth Hormone, Growth Hormone-Releasing Hormone
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