The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease
Abstract
Lipolysis is the process by which triglycerides (TGs) are hydrolyzed to free fatty acids (FFAs) and glycerol. In adipocytes, this is achieved by sequential action of adipose TG lipase (ATGL), hormone-sensitive lipase (HSL), and monoglyceride lipase. The activity in the lipolytic pathway is tightly regulated by hormonal and nutritional factors. Under conditions of negative energy balance such as fasting and exercise, stimulation of lipolysis results in a profound increase in FFA release from adipose tissue (AT). This response is crucial in order to provide the organism with a sufficient supply of substrate for oxidative metabolism. However, failure to efficiently suppress lipolysis when FFA demands are low can have serious metabolic consequences and is believed to be a key mechanism in the development of type 2 diabetes in obesity. As the discovery of ATGL in 2004, substantial progress has been made in the delineation of the remarkable complexity of the regulatory network controlling adipocyte lipolysis. Notably, regulatory mechanisms have been identified on multiple levels of the lipolytic pathway, including gene transcription and translation, post-translational modifications, intracellular localization, protein–protein interactions, and protein stability/degradation. Here, we provide an overview of the recent advances in the field of AT lipolysis with particular focus on the molecular regulation of the two main lipases, ATGL and HSL, and the intracellular and extracellular signals affecting their activity.
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Dose-Response Effect of Elevated Plasma Free Fatty Acid on Insulin Signaling
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Synthetic fluorescent probes for studying copper in biological systems
Cotruvo, Jr., Aron, A. T., Ramos-Torres, K. M., & Chang, C. J. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00346b · Cited by 558
Adipocyte lipolysis and insulin resistance
Morigny, P., Houssier, M., Mouisel, E., & Langin, D. (2016) · Biochimie · doi:10.1016/j.biochi.2015.10.024 · Cited by 469
Regulation and Metabolic Significance of De Novo Lipogenesis in Adipose Tissues
Song, Z., Xiaoli, A. M., & Yang, F. (2018) · Nutrients · doi:10.3390/nu10101383 · Cited by 435
A lipase-independent pathway of lipid release and immune modulation by adipocytes
Flaherty, S. E., Grijalva, A., Xu, X., Ables, E., Nomani, A., & Ferrante, A. W. (2019) · Science · doi:10.1126/science.aaw2586 · Cited by 382
The AMPK pathway in fatty liver disease
Fang, C., Pan, J., Qu, N., Lei, Y., Han, J., Zhang, J., & Han, D. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.970292 · Cited by 364
Metadata
- Authors
- Nielsen, T. S., Jessen, N., Jørgensen, J. O. L., Møller, N., & Lund, S.
- Venue
- Journal of Molecular Endocrinology
- Publisher
- Bioscientifica
- Published
- 2014-02-27
- Volume
- 52
- Issue
- 3
- Pages
- R199-R222
- ISSN
- 0952-5041 (ISSN-L)
- 1479-6813
- OpenAlex
- W2144741116
- Cited by
- 380
- References
- 22
- FWCI
- 11.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nielsen, T. S., Jessen, N., Jørgensen, J. O. L., Møller, N., & Lund, S. (2014). Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease. Journal of Molecular Endocrinology. https://doi.org/10.1530/jme-13-0277
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