The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
A lipase-independent pathway of lipid release and immune modulation by adipocytes
Open accessAbstract
Exosomes that fatten immune cells: Adipose tissue in mammals contains not only adipocytes (fat cells) but also a variety of immune cells—most notably, macrophages. Proper communication between these cell types is thought to be important for metabolic health. Flaherty et al. found that adipocytes release lipid-filled vesicles (AdExos) that serve as the primary source of lipid for adipose-resident macrophages (see the Perspective by Antonyak et al. ). AdExos were present at low levels in the circulation of mice and were produced at twice the rate in obese versus lean animals. In vitro, AdExos induced differentiation of bone marrow precursor cells into cells resembling adipose-resident macrophages. Science , this issue p. 989 ; see also p. 931
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Extracellular vesicles: Exosomes, microvesicles, and friends
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Adipose-derived circulating miRNAs regulate gene expression in other tissues
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Self-citationComparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease
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Cited by
Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease
Mori, M. A., Ludwig, R. G., Garcia-Martin, R., Brandão, B. B., & Kahn, C. R. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.07.011 · Cited by 961
Exosomes as mediators of intercellular crosstalk in metabolism
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Application of exosomes as liquid biopsy in clinical diagnosis
Zhou, B., Xu, K., Zheng, X., Chen, T., Wang, J., Song, Y., Shao, Y., & Zheng, S. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00258-9 · Cited by 685
Mechanisms of Fibrosis Development in Nonalcoholic Steatohepatitis
Schwabe, R. F., Tabas, I., & Pajvani, U. B. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.11.311 · Cited by 671
Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics
Morigny, P., Boucher, J., Arner, P., & Langin, D. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00471-8 · Cited by 527
Metadata
- Authors
- Flaherty, S. E., Grijalva, A., Xu, X., Ables, E., Nomani, A., & Ferrante, A. W.
- Venue
- Science
- Published
- 2019-03
- Volume
- 363
- Issue
- 6430
- Pages
- 989-993
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2916903506
- Cited by
- 382
- References
- 23
- FWCI
- 17.47
- Type
- journal article
- Language
- en
- Open access
- green
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