The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.
PI3K/PTEN/Akt and TSC/mTOR signaling pathways, ovarian dysfunction, and infertility: an update
Abstract
Abnormalities in ovarian function, including defective oogenesis and folliculogenesis, represent a key female reproductive deficiency. Accumulating evidence in the literature has shown that the PI3K/PTEN/Akt and TSC/mTOR signaling pathways are critical regulators of ovarian function including quiescence, activation, and survival of primordial follicles, granulosa cell proliferation and differentiation, and meiotic maturation of oocytes. Dysregulation of these signaling pathways may contribute to infertility caused by impaired follicular development, intrafollicular oocyte development, and ovulation. This article reviews the current state of knowledge of the functional role of the PI3K/PTEN/Akt and TSC/mTOR pathways during mammalian oogenesis and folliculogenesis and their association with female infertility.
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“In the context of ovarian function, the above-mentioned pathways “PIP3 activates AKT signalling” and “PI5P, PP2A and IER3 regulate PI3K/AKT signalling” have been previously studied [36–38].”
From Hsa-mir-548 family expression in human reproductive tissues (2021) · cites this paper as [38]
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Citations
Cites
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Cited by
Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice
Cavalcante, M. B., Saccon, T. D., Nunes, A. D. C., Kirkland, J. L., Tchkonia, T., Schneider, A., & Masternak, M. M. (2020) · Aging · doi:10.18632/aging.102772 · Cited by 80
Hsa-mir-548 family expression in human reproductive tissues
Rooda, I., Kaselt, B., Liivrand, M., Smolander, O.-P., Salumets, A., & Velthut-Meikas, A. (2021) · BMC Genomic Data · doi:10.1186/s12863-021-00997-w · Cited by 17
Metadata
- Authors
- Makker, A., Goel, M. M., & Mahdi, A. A.
- Venue
- Journal of Molecular Endocrinology
- Publisher
- Bioscientifica
- Published
- 2014-10-13
- Volume
- 53
- Issue
- 3
- Pages
- R103-R118
- ISSN
- 0952-5041
- 1479-6813
- Cited by
- 214
- References
- 116
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- Makker, A., Goel, M. M., & Mahdi, A. A. (2014). PI3K/PTEN/Akt and TSC/mTOR signaling pathways, ovarian dysfunction, and infertility: an update. Journal of Molecular Endocrinology. https://doi.org/10.1530/jme-14-0220
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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