The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment
Open accessAbstract
Significance: Human ovaries hold follicles containing oocytes. When follicles mature, they release eggs for fertilization. Patients with primary ovarian insufficiency develop menopausal symptoms at less than 40 y of age. They have few remaining follicles and their only chance for bearing a baby is through egg donation. Kawamura et al. demonstrated that Hippo and Akt signaling pathways regulate follicle growth. Using an in vitro activation approach, they first removed ovaries from infertile patients, followed by fragmentation to disrupt Hippo signaling and drug treatment to stimulate Akt signaling. After grafting ovarian tissues back to patients, they found rapid follicle growth in some patients and successfully retrieved mature eggs. After in vitro fertilization and embryo transfer, a live birth is now reported.
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Cites
Initial and cyclic recruitment of ovarian follicles
McGee, E. A., & Hsueh, A. J. W. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.2.0394 · Cited by 1,771
Self-citationOvarian aging: mechanisms and clinical consequences
Broekmans, F. J., Soules, M. R., & Fauser, B. C. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0006 · Cited by 1,248
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal
Zhao, B., Tumaneng, K., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2303 · Cited by 1,205
Cited by
Gellert, S. E., Pors, S. E., Kristensen, S. G., Bay-Bjørn, A. M., Ernst, E., & Yding Andersen, C. (2018) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-018-1144-2 · Cited by 282
Monniaux, D., Clément, F., Dalbiès-Tran, R., Estienne, A., Fabre, S., Mansanet, C., & Monget, P. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.113.117077 · Cited by 233
PI3K/PTEN/Akt and TSC/mTOR signaling pathways, ovarian dysfunction, and infertility: an update
Makker, A., Goel, M. M., & Mahdi, A. A. (2014) · Journal of Molecular Endocrinology · doi:10.1530/jme-14-0220 · Cited by 214
Schleedoorn, M. J., Mulder, B. H., Braat, D. D. M., Beerendonk, C. C. M., Peek, R., Nelen, W. L. D. M., Van Leeuwen, E., Van der Velden, A. A. E. M., & Fleischer, K. (2020) · Human Reproduction · doi:10.1093/humrep/deaa007 · Cited by 43
Is polycystic ovary syndrome a sexual conflict? A review
Casarini, L., Simoni, M., & Brigante, G. (2016) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2016.01.011 · Cited by 28
“, 2015), and it has been indicated as a possible target for infertility treatments in PCOS or primary ovarian insufficiency affected women (Kawamura et al., 2013).”
Background
Metadata
- Authors
- Kawamura, K., Cheng, Y., Suzuki, N., Deguchi, M., Sato, Y., Takae, S., Ho, C.-H., Kawamura, N., Tamura, M., Hashimoto, S., Sugishita, Y., Morimoto, Y., Hosoi, Y., Yoshioka, N., Ishizuka, B., & Hsueh, A. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-09-30
- Volume
- 110
- Issue
- 43
- Pages
- 17474-17479
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2124556975
- Cited by
- 863
- References
- 3
- FWCI
- 41.28
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment. https://app.cochat.ai/papers/10.1073/pnas.1312830110
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- Kawamura, K., Cheng, Y., Suzuki, N., Deguchi, M., Sato, Y., Takae, S., Ho, C.-H., Kawamura, N., Tamura, M., Hashimoto, S., Sugishita, Y., Morimoto, Y., Hosoi, Y., Yoshioka, N., Ishizuka, B., & Hsueh, A. J. (2013). Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1312830110
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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