The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.
The diversity of sex steroid action: regulation of metabolism by estrogen signaling
Open accessAbstract
The metabolic syndrome is a complex condition characterized by obesity, insulin resistance, decreased high-density lipoproteins, and hypertension associated with high risk of developing type 2 diabetes and cardiovascular disease. A major increase in the incidence of developing metabolic syndrome and related diseases is observed worldwide in association with a change toward a less active lifestyle and increased food consumption. Estrogen and the estrogen receptors (ERs) are well-known regulators of several aspects of metabolism, including glucose and lipid metabolism, and impaired estrogen signaling is associated with the development of metabolic diseases. This review will describe the key effects of estrogen signaling in metabolic and glucose sensing tissues, including the liver, pancreatic β cells, adipose tissue, and skeletal muscle. The impact on metabolic processes of impaired estrogen signaling and knock out of each ER subtype will also be discussed.
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“The classical genomic action mechanism of ER action typically occurs within hours, leading to activation or repression of target genes.”
From Estrogen deficiency and the origin of obesity during menopause (2014) · cites this paper as [51]
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Metadata
- Authors
- Faulds, M. H., Zhao, C., Dahlman-Wright, K., & Gustafsson, J.-Å.
- Affiliations
- Karolinska Institutet (SE)
- ORCID
- Zhao, Chunyan
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2011-04-21
- Volume
- 212
- Issue
- 1
- Pages
- 3-12
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2140387377
- Cited by
- 230
- References
- 105
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 15 · 2023: 14 · 2022: 10 · 2021: 12 · 2020: 18 · 2019: 6 · 2018: 13 · 2017: 17 · 2016: 15 · 2015: 23 · 2014: 24 · 2013: 26 · 2012: 16
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- estrogen signaling, estrogen receptor, metabolic syndrome, glucose metabolism, lipid metabolism, insulin resistance, obesity, type 2 diabetes, cardiovascular disease, hepatic glucose metabolism, pancreatic beta cells, adipose tissue, skeletal muscle
- MeSH terms
- Animals, Cholesterol, Estrogens, Glucose, Homeostasis, Humans, Inflammation, Insulin Resistance, Lipolysis, Metabolic Syndrome, Lipogenesis
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