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Cited by 99Stress Responses and CortisolPancreatic function and diabetesAdipokines, Inflammation, and Metabolic Diseases

Acute psychological stress results in the rapid development of insulin resistance

Open access
Li, Li, Li, Xiaohua, Zhou, Wenjun, Messina, Joseph L·2013·Journal of Endocrinology
DOI 10.1530/joe-12-0559PMC PMC3804337
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Abstract

In recent years, the roles of chronic stress and depression as independent risk factors for decreased insulin sensitivity and the development of diabetes have been increasingly recognized. However, an understanding of the mechanisms linking insulin resistance and acute psychological stress are very limited. We hypothesized that acute psychological stress may cause the development of insulin resistance, which may be a risk factor in developing type 2 diabetes. We tested the hypothesis in a well-established mouse model using 180 episodes of inescapable foot shock (IES) followed by a behavioral escape test. In this study, mice that received IES treatment were tested for acute insulin resistance by measuring glucose metabolism and insulin signaling. When compared with normal and sham mice, mice that were exposed to IES resulting in escape failure (defined as IES with behavioral escape failure) displayed elevated blood glucose levels in both glucose tolerance and insulin tolerance tests. Furthermore, mice with IES exposure and behavioral escape failure exhibited impaired hepatic insulin signaling via the insulin-induced insulin receptor/insulin receptor substrate 1/Akt pathway, without affecting similar pathways in skeletal muscle, adipose tissue, and brain. Additionally, a rise in the murine growth-related oncogene KC/GRO was associated with impaired glucose metabolism in IES mice, suggesting a mechanism by which psychological stress by IES may influence glucose metabolism. The present results indicate that psychological stress induced by IES can acutely alter hepatic responsiveness to insulin and affect whole-body glucose metabolism.

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  • Physiological regulation of insulin function can be viewed as an adaptive mechanism to regulate the metabolic pathway of insulin signaling (PI-3K) in response to changing environmental conditions or during normal alterations of internal states.

    “Physiological regulation of insulin function can be viewed as an adaptive mechanism to regulate the metabolic pathway of insulin signaling (PI-3K), in response to changing environmental conditions [starvation, fear, stress] [164,165] or during normal alterations of internal states (pregnancy, lactation, adolescence) [65,146,152].”

    From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [165]

    The Results section ('Decreased insulin signaling in the liver following acute psychological stress'; page unavailable) reports reduced activation of components of the IR/IRS1/PI3K/AKT pathway after acute stress in mice. This supports the stress-related part of the citation, but the paper does not establish that the change is an adaptive mechanism or address starvation or fear. The normal internal states in the citing sentence have separate citations. (LLM, conf=0.84)

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Cited by

Sorted by citations

Authors
Li, L., Li, X., Zhou, W., & Messina, J. L.
Affiliations
  • University of Alabama at Birmingham (US)
  • St. Vincent's Birmingham (US)
  • University of Illinois Urbana-Champaign (US)
ORCID
Venue
Journal of Endocrinology
Publisher
Bioscientifica
Published
2013-02-26
Volume
217
Issue
2
Pages
175-184
ISSN
  • 0022-0795 (ISSN-L)
  • 1479-6805
DOI
10.1530/joe-12-0559
PMC
PMC3804337
OpenAlex
W2138463688
Cited by
99
References
7
Citations by year
2026: 5 · 2025: 8 · 2024: 5 · 2023: 8 · 2022: 6 · 2021: 11 · 2020: 11 · 2019: 8 · 2018: 9 · 2017: 4 · 2016: 7 · 2015: 9 · 2014: 6 · 2013: 2
FWCI
3.65
Type
journal article
Language
en
Open access
Locations
  • Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (DK62071, R01DK062071, P30DK079626)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
acute psychological stress, insulin resistance, type 2 diabetes, inescapable footshock, hepatic insulin signaling, glucose metabolism, stress hyperglycemia
MeSH terms
Animals, Behavior, Animal, Disease Models, Animal, Glucose, Insulin, Insulin Resistance, Male, Mice, Inbred C57BL, Receptor, Insulin, Stress, Psychological, Signal Transduction, Proto-Oncogene Proteins c-akt, Mice

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