The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.
Glucocorticoid treatment and endocrine pancreas function: implications for glucose homeostasis, insulin resistance and diabetes
Open accessAbstract
Glucocorticoids (GCs) are broadly prescribed for numerous pathological conditions because of their anti-inflammatory, antiallergic and immunosuppressive effects, among other actions. Nevertheless, GCs can produce undesired diabetogenic side effects through interactions with the regulation of glucose homeostasis. Under conditions of excess and/or long-term treatment, GCs can induce peripheral insulin resistance (IR) by impairing insulin signalling, which results in reduced glucose disposal and augmented endogenous glucose production. In addition, GCs can promote abdominal obesity, elevate plasma fatty acids and triglycerides, and suppress osteocalcin synthesis in bone tissue. In response to GC-induced peripheral IR and in an attempt to maintain normoglycaemia, pancreatic β-cells undergo several morphofunctional adaptations that result in hyperinsulinaemia. Failure of β-cells to compensate for this situation favours glucose homeostasis disruption, which can result in hyperglycaemia, particularly in susceptible individuals. GC treatment does not only alter pancreatic β-cell function but also affect them by their actions that can lead to hyperglucagonaemia, further contributing to glucose homeostasis imbalance and hyperglycaemia. In addition, the release of other islet hormones, such as somatostatin, amylin and ghrelin, is also affected by GC administration. These undesired GC actions merit further consideration for the design of improved GC therapies without diabetogenic effects. In summary, in this review, we consider the implication of GC treatment on peripheral IR, islet function and glucose homeostasis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
Endocrine regulation of energy metabolism by the skeleton
Lee, N. K., Sowa, H., Hinoi, E., Ferron, M., Ahn, J. D., Confavreux, C., Dacquin, R., Mee, P. J., McKee, M. D., Jung, D. Y., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.047 · Cited by 2,554
Mechanisms involved in the side effects of glucocorticoids
SCHACKE, H. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00297-8 · Cited by 1,847
Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus
Westermark, P., Andersson, A., & Westermark, G. T. (2011) · Physiological Reviews · doi:10.1152/physrev.00042.2009 · Cited by 1,044
Ferron, M., Hinoi, E., Karsenty, G., & Ducy, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711119105 · Cited by 900
Glucocorticoids and insulin resistance: old hormones, new targets
ANDREWS, R. C., & WALKER, B. R. (1999) · Clinical Science · doi:10.1042/cs0960513 · Cited by 731
RIZZA, R. A., MANDARINO, L. J., & GERICH, J. E. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-1-131 · Cited by 696
Ghrelin Modulates Brain Activity in Areas that Control Appetitive Behavior
Malik, S., McGlone, F., Bedrossian, D., & Dagher, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.03.007 · Cited by 677
The Pathogenetic Role of Cortisol in the Metabolic Syndrome: A Hypothesis
Anagnostis, P. G., Athyros, V. G., Τζιόμαλος, Κ., Karagiannis, A. I., & Mikhailidis, D. P. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0370 · Cited by 625
Genomic and nongenomic effects of glucocorticoids
Stahn, C., & Buttgereit, F. (2008) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0898 · Cited by 594
Research works printed but not linked: 18
- 1984, American Journal of Physiology -- Legacy Content, 247, E592
- Brown, 1993, Endocrinology, 132, 2614, 10.1210/en.132.6.2614 · DOI · Paper page
- Hoes, 2010, Clinical and experimental rheumatology, 28, 354
- 1992, American Journal of Physiology -- Legacy Content, 263, E663
- 2014, Endocrinology, 27, 48
- 2011, MODERN RHEUMATOLOGY, 21, 495, 10.3109/s10165-011-0433-8 · DOI
- 1994, JOURNAL OF CLINICAL ENDOCRINOLOGY, 79, 820
- 1994, JOURNAL OF CLINICAL ENDOCRINOLOGY, 78, 1354
- 1993, American Journal of Physiology -- Legacy Content, 265, E446
- 1993, JOURNAL OF CLINICAL ENDOCRINOLOGY, 77, 1180
- 1998, American Journal of Physiology -- Legacy Content, 275, E806
- 1994, Journal of liposome research, 35, 1535
- 2008, NATURE CLINICAL PRACTICE RHEUMATOLOGY, 4, 525
- 1990, American Journal of Physiology -- Legacy Content, 258, E748
- T uber, 1984, International journal of clinical pharmacology, therapy, and toxicology, 22, 48
- 1990, American Journal of Physiology -- Legacy Content, 259, E626
- 1992, PNAS, 89, 35
- 2013, Journal of Molecular Endocrinology, 19, R35
Cited by
Sorted by citations
The crucial role and mechanism of insulin resistance in metabolic disease
Zhao, X., An, X., Yang, C., Sun, W., Ji, H., & Lian, F. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1149239 · Cited by 675
Fresh insights into glucocorticoid-induced diabetes mellitus and new therapeutic directions
Li, J.-X., & Cummins, C. L. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00683-6 · Cited by 285
Glucocorticoids and bone: consequences of endogenous and exogenous excess and replacement therapy
Hardy, R. S., Zhou, H., Seibel, M. J., & Cooper, M. S. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00097 · Cited by 258
Sabir, S., Akash, M. S. H., Fiayyaz, F., Saleem, U., Mehmood, M. H., & Rehman, K. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108802 · Cited by 165
Glucocorticoid Signaling: An Update from a Genomic Perspective
Sacta, M. A., Chinenov, Y. V., & Rogatsky, I. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105323 · Cited by 155
Metadata
- Authors
- Rafacho, A., Ortsäter, H., Nadal, A., & Quesada, I.
- Affiliations
- Universitat de Miguel Hernández d'Elx (ES)
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2014-09-30
- Volume
- 223
- Issue
- 3
- Pages
- R49-R62
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2170071103
- Cited by
- 216
- References
- 124
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 21 · 2023: 14 · 2022: 19 · 2021: 18 · 2020: 18 · 2019: 27 · 2018: 27 · 2017: 16 · 2016: 22 · 2015: 15 · 2014: 1
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
- Funders
- European Foundation for the Study of Diabetes
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (471397/2011-3)
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
- Instituto de Salud Carlos III
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- glucocorticoids, diabetogenic effect, glucose homeostasis, insulin resistance, beta-cell function, hyperinsulinemia, hyperglycemia, hyperglucagonaemia, islet hormones, somatostatin, amylin, ghrelin, osteocalcin, abdominal obesity, insulin signaling
- MeSH terms
- Animals, Blood Glucose, Diabetes Mellitus, Type 2, Glucocorticoids, Glucose, Homeostasis, Humans, Insulin Resistance, Islets of Langerhans, Models, Biological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
