Cited by 216Pancreatic function and diabetesDiabetes Treatment and ManagementAdrenal Hormones and Disorders

The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.

Glucocorticoid treatment and endocrine pancreas function: implications for glucose homeostasis, insulin resistance and diabetes

Open access

Rafacho, Alex, Ortsäter, Henrik, Nadal, Angel, Quesada, Ivan·2014·Journal of Endocrinology

Open this paper in CoChat — free account Open PDF

Abstract

Glucocorticoids (GCs) are broadly prescribed for numerous pathological conditions because of their anti-inflammatory, antiallergic and immunosuppressive effects, among other actions. Nevertheless, GCs can produce undesired diabetogenic side effects through interactions with the regulation of glucose homeostasis. Under conditions of excess and/or long-term treatment, GCs can induce peripheral insulin resistance (IR) by impairing insulin signalling, which results in reduced glucose disposal and augmented endogenous glucose production. In addition, GCs can promote abdominal obesity, elevate plasma fatty acids and triglycerides, and suppress osteocalcin synthesis in bone tissue. In response to GC-induced peripheral IR and in an attempt to maintain normoglycaemia, pancreatic β-cells undergo several morphofunctional adaptations that result in hyperinsulinaemia. Failure of β-cells to compensate for this situation favours glucose homeostasis disruption, which can result in hyperglycaemia, particularly in susceptible individuals. GC treatment does not only alter pancreatic β-cell function but also affect them by their actions that can lead to hyperglucagonaemia, further contributing to glucose homeostasis imbalance and hyperglycaemia. In addition, the release of other islet hormones, such as somatostatin, amylin and ghrelin, is also affected by GC administration. These undesired GC actions merit further consideration for the design of improved GC therapies without diabetogenic effects. In summary, in this review, we consider the implication of GC treatment on peripheral IR, islet function and glucose homeostasis.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1530/joe-14-0373

Cites

125 of 125 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
Endocrine regulation of energy metabolism by the skeleton
Lee, N. K., Sowa, H., Hinoi, E., Ferron, M., Ahn, J. D., Confavreux, C., Dacquin, R., Mee, P. J., McKee, M. D., Jung, D. Y., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.047 · Cited by 2,554
Mechanisms involved in the side effects of glucocorticoids
SCHACKE, H. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00297-8 · Cited by 1,847
Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus
Westermark, P., Andersson, A., & Westermark, G. T. (2011) · Physiological Reviews · doi:10.1152/physrev.00042.2009 · Cited by 1,044
Osteocalcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice
Ferron, M., Hinoi, E., Karsenty, G., & Ducy, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711119105 · Cited by 900
Glucocorticoids and insulin resistance: old hormones, new targets
ANDREWS, R. C., & WALKER, B. R. (1999) · Clinical Science · doi:10.1042/cs0960513 · Cited by 731
Cortisol-Induced Insulin Resistance in Man: Impaired Suppression of Glucose Production and Stimulation of Glucose Utilization due to a Postreceptor Defect of Insulin Action*
RIZZA, R. A., MANDARINO, L. J., & GERICH, J. E. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-1-131 · Cited by 696
Ghrelin Modulates Brain Activity in Areas that Control Appetitive Behavior
Malik, S., McGlone, F., Bedrossian, D., & Dagher, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.03.007 · Cited by 677
The Pathogenetic Role of Cortisol in the Metabolic Syndrome: A Hypothesis
Anagnostis, P. G., Athyros, V. G., Τζιόμαλος, Κ., Karagiannis, A. I., & Mikhailidis, D. P. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0370 · Cited by 625
Genomic and nongenomic effects of glucocorticoids
Stahn, C., & Buttgereit, F. (2008) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0898 · Cited by 594
Use of oral corticosteroids in the United Kingdom
van Staa, T. P. (2000) · QJM · doi:10.1093/qjmed/93.2.105 · Cited by 529
Physiology of the pancreatic α-cell and glucagon secretion: role in glucose homeostasis and diabetes
Quesada, I., Tudurí, E., Ripoll, C., & Nadal, Á. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0290 · Cited by 447
Novel insights into glucocorticoid‐mediated diabetogenic effects: towards expansion of therapeutic options?
Van Raalte, D. H., Ouwens, D. M., & Diamant, M. (2009) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2008.02067.x · Cited by 439
Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets.
Lambillotte, C., Gilon, P., & Henquin, J. C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119175 · Cited by 419
How glucocorticoid receptors modulate the activity of other transcription factors: A scope beyond tethering
Ratman, D., Vanden Berghe, W., Dejager, L., Libert, C., Tavernier, J., Beck, I. M., & De Bosscher, K. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.12.014 · Cited by 411
Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats.
Saad, M. J., Folli, F., Kahn, J. A., & Kahn, C. R. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116803 · Cited by 349
Pancreatic beta cells are important targets for the diabetogenic effects of glucocorticoids.
Delaunay, F., Khan, A. R., Cintra, A., Davani, B., Ling, Z. C., Andersson, A., Östenson, C., Gustafsson, J.-Α., Efendić, S., & Okret, S. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119743 · Cited by 331
Modulation of Glucocorticoid Receptor Function via Phosphorylation
ISMAILI, N., & GARABEDIAN, M. J. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1321.007 · Cited by 318
New insights into the anti-inflammatory mechanisms of glucocorticoids: an emerging role for glucocorticoid-receptor-mediated transactivation
Vandevyver, S., Dejager, L., Tuckermann, J., & Libert, C. (2013) · Endocrinology · doi:10.1210/en.2012-2045 · Cited by 296 · cited 1×
“genomic actions (Vandevyver et al. 2013).”
Human placental 11 beta-hydroxysteroid dehydrogenase: evidence for and partial purification of a distinct NAD-dependent isoform.
Brown, R. W., Chapman, K. E., Edwards, C. R., & Seckl, J. R. (1993) · Endocrinology · doi:10.1210/endo.132.6.8504762 · Cited by 271
Effects of glucocorticoid excess on the sensitivity of glucose transport and metabolism to insulin in rat skeletal muscle
DIMITRIADIS, G., LEIGHTON, B., PARRY-BILLINGS, M., SASSON, S., YOUNG, M., KRAUSE, U., BEVAN, S., PIVA, T., WEGENER, G., & NEWSHOLME, E. A. (1997) · Biochemical Journal · doi:10.1042/bj3210707 · Cited by 266
Glucocorticoids and insulin resistance: old hormones, new targets
Andrews, R. C., & Walker, B. R. (1999) · Clinical Science · doi:10.1042/cs19980388 · Cited by 266
Hormonal regulation of hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytes.
Slavin, B. G., Ong, J. M., & Kern, P. A. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41151-4 · Cited by 261
An in vivo and in vitro study of the mechanism of prednisone-induced insulin resistance in healthy subjects.
Pagano, G., Cavallo-Perin, P., Cassader, M., Bruno, A., Ozzello, A., Masciola, P., Dall'omo, A. M., & Imbimbo, B. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111141 · Cited by 259
Chaperoning of Glucocorticoid Receptors
Pratt, W. B., Morishima, Y., Murphy, M. N., & Harrell, M. (2005) · Springer eBooks · doi:10.1007/3-540-29717-0_5 · Cited by 247
Glucocorticoid receptors recruit the CaMKIIα-BDNF-CREB pathways to mediate memory consolidation
Chen, D. Y., Bambah-Mukku, D., Pollonini, G., & Alberini, C. M. (2012) · Nature Neuroscience · doi:10.1038/nn.3266 · Cited by 226
Effect of chronic stress and exogenous glucocorticoids on regional fat distribution and metabolism
Rebuffé-Scrive, M., Walsh, U. A., McEwen, B. S., & Rodin, J. (1992) · Physiology & Behavior · doi:10.1016/0031-9384(92)90351-2 · Cited by 218
Novel insights into mechanisms of glucocorticoid action and the development of new glucocorticoid receptor ligands
Löwenberg, M., Stahn, C., Hommes, D. W., & Buttgereit, F. (2008) · Steroids · doi:10.1016/j.steroids.2007.12.002 · Cited by 205
The Course of Biochemical Parameters of Bone Turnover during Treatment with Corticosteroids
Prummel, M. F., Wiersinga, W. M., Lips, P. T. A. M., Sanders, G. T., & Sauerwein, H. P. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-2-382 · Cited by 202
Stimulation of Lipolysis in Humans by Physiological Hypercortisolemia
Divertie, G. D., Jensen, M. D., & Miles, J. M. (1991) · Diabetes · doi:10.2337/diab.40.10.1228 · Cited by 201
Monitoring adverse events of low-dose glucocorticoid therapy: EULAR recommendations for clinical trials and daily practice
van der Goes, M. C., Jacobs, J. W. G., Boers, M., Andrews, T., Blom-Bakkers, M. A. M., Buttgereit, F., Caeyers, N., Cutolo, M., da Silva, J. A. P., Guillevin, L., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.124958 · Cited by 194
Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism
Brennan‐Speranza, T. C., Henneicke, H., Gasparini, S. J., Blankenstein, K. I., Heinevetter, U., Cogger, V. C., Svistounov, D., Zhang, Y., Cooney, G. J., Buttgereit, F., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63377 · Cited by 191
Serum- and Glucocorticoid-Inducible Kinase 1 (SGK1) Mediates Glucocorticoid-Induced Inhibition of Insulin Secretion
Ullrich, S., Berchtold, S., Ranta, F., Seebohm, G., Henke, G., Lupescu, A., Mack, A. F., Chao, C., Su, J., Nitschke, R., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.4.1090 · Cited by 175
AMP‐activated protein kinase mediates glucocorticoid‐ induced metabolic changes: a novel mechanism in Cushing's syndrome
Christ‐Crain, M., Kola, B., Lolli, F., Fekete, C., Seboek, D., Wittmann, G., Feltrin, D., Igreja, S., Ajodha, S. J., Harvey-White, J. D., et al. (2008) · The FASEB Journal · doi:10.1096/fj.07-094144 · Cited by 175
11β-Hydroxysteroid Dehydrogenase Type 1 Regulates Glucocorticoid-Induced Insulin Resistance in Skeletal Muscle
Morgan, S., Sherlock, M., Gathercole, L., Lavery, G. G., Lenaghan, C., Bujalska, I. J., Laber, D., Yu, A., Convey, G., Mayers, R. M., et al. (2009) · Diabetes · doi:10.2337/db09-0525 · Cited by 174
Mineralocorticoid excess and inhibition of 11 β‐hydroxysteroid dehydrogenase in patients with ectopic ACTH syndrome
Walker, B. R., Campbell, J. C., Fräser, R., Stewart, P. M., & Edwards, C. R. W. (1992) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1992.tb01478.x · Cited by 171
Acute and 2-week exposure to prednisolone impair different aspects of β-cell function in healthy men
van Raalte, D. H., Nofrate, V., Bunck, M. C., van Iersel, T., Elassaiss Schaap, J., Nässander, U. K., Heine, R. J., Mari, A., Dokter, W. H. A., & Diamant, M. (2010) · European Journal of Endocrinology · doi:10.1530/eje-09-1034 · Cited by 170
Roles of insulin resistance and beta-cell dysfunction in dexamethasone-induced diabetes.
Ogawa, A., Johnson, J. H., Ohneda, M., McAllister, C. T., Inman, L., Alam, T., & Unger, R. H. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115886 · Cited by 159
Hyperglucagonism Induced by Glucocorticoid Treatment in Man
Marco, J., Calle, C., Román, D., Díaz-Fierros, M., Villanueva, M. L., & Valverde, I. (1973) · New England Journal of Medicine · doi:10.1056/nejm197301182880305 · Cited by 159
The effects of acute and chronic dexamethasone administration on insulin binding to isolated rat hepatocytes and adipocytes
Olefsky, J. M., Johnson, J. W., Liu, F., Jen, P., & Reaven, G. M. (1975) · Metabolism · doi:10.1016/0026-0495(75)90076-1 · Cited by 149
Ghrelin Directly Stimulates Glucagon Secretion from Pancreatic α-Cells
Chuang, J.-C., Sakata, I., Kohno, D., Perello, M., Osborne-Lawrence, S., Repa, J. J., & Zigman, J. M. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-1001 · Cited by 141
Archives of Medical Research
(2003) · Archives of Medical Research · doi:10.1016/s0188-4409(03)00039-0 · Cited by 140
Characterization of regional and gender differences in glucocorticoid receptors and lipoprotein lipase activity in human adipose tissue.
Pedersen, S. B., Jønler, M., & Richelsen, B. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.6.8200937 · Cited by 130
Dissecting the Role of Glucocorticoids on Pancreas Development
Gesina, E., Tronche, F., Herrera, P. L., Duchêne, B., Tales, W., Czernichow, P., & Bréant, B. (2004) · Diabetes · doi:10.2337/diabetes.53.9.2322 · Cited by 128
The islet ghrelin cell
Wierup, N., Sundler, F., & Heller, R. S. (2013) · Journal of Molecular Endocrinology · doi:10.1530/jme-13-0122 · Cited by 128
Glucocorticoid-induced Insulin Resistance
Caro, J. F., & Amatruda, J. M. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110526 · Cited by 125
Metabolic Adaptations to Dexamethasone‐Induced Insulin Resistance in Healthy Volunteers
Nicod, N., Giusti, V., Besse, C., & Tappy, L. (2003) · Obesity Research · doi:10.1038/oby.2003.90 · Cited by 125
Isolation of a cDNA for the Catalytic Subunit of Rat Liver Glucose-6-Phosphatase: Regulation of Gene Expression in FAO Hepatoma Cells by Insulin, Dexamethasone and cAMP
Lange, A., Argaud, D., El‐Maghrabi, M. R., Pan, W., Maitra, S. R., & Pilkis, S. J. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1702 · Cited by 123
LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice
Patel, R., Patel, M., Tsai, R., Lin, V. Y., Bookout, A. L., Zhang, Y., Magomedova, L., Li, T., Chan, J. F., Budd, C., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41681 · Cited by 121
Effect of Corticosterone on Insulin and Glucagon Secretion by the Isolated Perfused Rat Pancreas*
Barseghian, G., & Levine, R. (1980) · Endocrinology · doi:10.1210/endo-106-2-547 · Cited by 118
Optimized glucocorticoid therapy: teaching old drugs new tricks
Strehl, C., & Buttgereit, F. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.01.026 · Cited by 118
Direct glucocorticoid receptor–Stat5 interaction in hepatocytes controls body size and maturation-related gene expressionPreprint
Engblom, D., Kornfeld, J., Schwake, L., Tronche, F., Reimann, A., Beug, H., Hennighausen, L. G., Moriggl, R., & Schütz, G. (2007) · Genes & Development · doi:10.1101/gad.426007 · Cited by 117
Evaluation of Alpha-Cell Function by Infusion of Alanine in Normal, Diabetic and Obese Subjects
Wise, J. K., Hendler, R., & Felig, P. (1973) · New England Journal of Medicine · doi:10.1056/nejm197303082881003 · Cited by 114
Type 1 11β-Hydroxysteroid Dehydrogenase Mediates Glucocorticoid Activation and Insulin Release in Pancreatic Islets
Davani, B., Khan, A., Hult, M., Mårtensson, E., Okret, S., Efendić, S., Jörnvall, H., & Oppermann, U. C. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000600200 · Cited by 112
High doses of dexamethasone induce increased β-cell proliferation in pancreatic rat islets
Rafacho, A., Cestari, T. M., Taboga, S. R., Boschero, A. C., & Bosqueiro, J. R. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90931.2008 · Cited by 110
Dexamethasone-induced insulin resistance enhances B cell responsiveness to glucose level in normal men
Beard, J. C., Halter, J. B., Best, J. D., Pfeifer, M. A., & Porte, D. (1984) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1984.247.5.e592 · Cited by 109
Glucocorticoids Regulate Transcription of the Gene for Phosphoenolpyruvate Carboxykinase in the Liver via an Extended Glucocorticoid Regulatory Unit
Cassuto, H., Kochan, K., Chakravarty, K., Cohen, H., Blum, B., Olswang, Y., Hakimi, P., Xu, C., Massillon, D., Hanson, R. W., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504119200 · Cited by 108
'Liver-type' 11β-hydroxysteroid dehydrogenase cDNA encodes reductase but not dehydrogenase activity in intact mammalian COS-7 cells
Low, S. C., Chapman, K. E., Edwards, C. R. W., & Seckl, J. R. (1994) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0130167 · Cited by 108
The diabetogenic effects of glucocorticoids are more pronounced in low- than in high-insulin responders.
Wajngot, A., Giacca, A., Grill, V, Vranic, M., & Efendic, S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.6035 · Cited by 105
Endogenous and exogenous glucocorticoids decrease plasma ghrelin in humans
Otto, B., Tschöp, M. H., Heldwein, W., Pfeiffer, A. F. H., & Diederich, S. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1510113 · Cited by 105
Rapid nongenomic inhibitory effects of glucocorticoids on phagocytosis and superoxide anion production by macrophages
Long, F., Wang, Y., Liu, L., Zhou, J., Cui, R.-Y., & Jiang, C.-L. (2004) · Steroids · doi:10.1016/j.steroids.2004.10.004 · Cited by 99
11β-hydroxysteroid dehydrogenase type 1 expression in 2S FAZA hepatoma cells is hormonally regulated: a model system for the study of hepatic glucocorticoid metabolism
Voice, M. W., Seckl, J. R., Edwards, C. R. W., & Chapman, K. E. (1996) · Biochemical Journal · doi:10.1042/bj3170621 · Cited by 92
Treatment With Growth Hormone and Dexamethasone in Mice Transgenic for Human Islet Amyloid Polypeptide Causes Islet Amyloidosis and β-Cell Dysfunction
Couce, M., Kane, L. A., O’Brien, T. D., Charlesworth, J. E., Soeller, W. C., McNeish, J. D., Kreutter, D. K., Roche, P. C., & Butler, P. C. (1996) · Diabetes · doi:10.2337/diab.45.8.1094 · Cited by 91
Changes in Adenosine 5′-Monophosphate-Activated Protein Kinase as a Mechanism of Visceral Obesity in Cushing’s Syndrome
Kola, B., Christ‐Crain, M., Lolli, F., Arnaldi, G., Giacchetti, G., Boscaro, M., Grossman, A. B., & Korbonits, M. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1297 · Cited by 89
Functional Alterations in Endocrine Pancreas of Rats With Different Degrees of Dexamethasone-Induced Insulin Resistance
Rafacho, A., Giozzet, V. A. G., Boschero, A. C., & Bosqueiro, J. R. (2008) · Pancreas · doi:10.1097/mpa.0b013e31815ba826 · Cited by 88
Aged Transgenic Mice With Increased Glucocorticoid Sensitivity in Pancreatic β-Cells Develop Diabetes
Davani, B., Portwood, N., Bryzgalova, G., Reimer, M. K., Heiden, T., Östenson, C., Okret, S., Åhrén, B., Efendić, S., & Khan, A. (2004) · Diabetes · doi:10.2337/diabetes.53.2007.s51 · Cited by 82
Glucocorticoids in Vivo Induce Both Insulin Hypersecretion and Enhanced Glucose Sensitivity of Stimulus-Secretion Coupling in Isolated Rat Islets
Rafacho, A., Marroquí, L., Taboga, S. R., Abrantes, J. L. F., Silveira, L. R., Boschero, A. C., Carneiro, E. M., Bosqueiro, J. R., Nadal, A., & Quesada, I. (2010) · Endocrinology · doi:10.1210/en.2009-0704 · Cited by 80
Troglitazone Antagonizes Metabolic Effects of Glucocorticoids in Humans
Willi, S. M., Kennedy, A., Wallace, P., Ganaway, E., Rogers, N. L., & Garvey, W. T. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2895 · Cited by 77
Kinetics of dexamethasone-induced alterations of glucose metabolism in healthy humans
Schneiter, P., & Tappy, L. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.5.e806 · Cited by 77
The effect of cortisol on glucose/glucose-6-phosphate cycle activity and insulin action.
Rooney, D. P., Neely, R. D., Cullen, C., Ennis, C. N., Sheridan, B., Atkinson, A. B., Trimble, E. R., & Bell, P. M. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.5.8077310 · Cited by 76
Direct Effect of Corticosterone upon Insulin Secretion Studied by Three Different Techniques
Billaudel, B. J. L., & Sutter, B. C. J. (1979) · Hormone and Metabolic Research · doi:10.1055/s-0028-1092779 · Cited by 74
Insulin resistant subjects lack islet adaptation to short-term dexamethasone-induced reduction in insulin sensitivity
Larsson, H., & Ahrén, B. (1999) · Diabetologia · doi:10.1007/s001250051251 · Cited by 73
Morphofunctional Alterations in Endocrine Pancreas of Short- and Long-term Dexamethasone-treated Rats
Rafacho, A., Abrantes, J. L. F., Ribeiro, D. L., Paula, F. M. D., Pinto‐Fochi, M. E., Boschero, A. C., & Bosqueiro, J. R. (2011) · Hormone and Metabolic Research · doi:10.1055/s-0030-1269896 · Cited by 71
Altered islet amyloid polypeptide (amylin) gene expression in rat models of diabetes
Bretherton-Watt, D., Ghatei, M. A., Bloom, S. R., Jamal, H., Ferrier, G. J. M., Girgis, S. I., & Legon, S. (1989) · Diabetologia · doi:10.1007/bf00297454 · Cited by 71
Glucocorticoid increases glucose cycling and inhibits insulin release in pancreatic islets of ob/ob mice.
Khan, A., Östenson, C., Berggren, P., & Eféndic, S. (1992) · American Journal of Physiology · doi:10.1152/ajpendo.1992.263.4.e663 · Cited by 71
Steroid-induced insulin resistance and impaired glucose tolerance are both associated with a progressive decline of incretin effect in first-degree relatives of patients with type 2 diabetes
Jensen, D. H., Aaboe, K., Henriksen, J. E., Vølund, A., Holst, J. J., Madsbad, S., & Krarup, T. (2012) · Diabetologia · doi:10.1007/s00125-012-2459-7 · Cited by 70
Pancreatic Alpha-Cell Dysfunction Contributes to the Disruption of Glucose Homeostasis and Compensatory Insulin Hypersecretion in Glucocorticoid-Treated Rats
Rafacho, A., Gonçalves-Neto, L. M., Santos-Silva, J. C., Alonso‐Magdalena, P., Merino, B., Taboga, S. R., Carneiro, E. M., Boschero, A. C., Nadal, Á., & Quesada, I. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093531 · Cited by 69
Glucocorticoid induced insulin resistance impairs basal but not glucose entrained high-frequency insulin pulsatility in humans
Hollingdal, M., Juhl, C. B., Dall, R., Sturis, J., Veldhuis, J. D., Schmitz, O., & Pørksen, N. (2002) · Diabetologia · doi:10.1007/s125-002-8244-y · Cited by 67
Prednisolone-induced beta cell dysfunction is associated with impaired endoplasmic reticulum homeostasis in INS-1E cells
Linssen, M. M. L., van Raalte, D. H., Toonen, E. J. M., Alkema, W. B. L., van der Zon, G. C., Dokter, W. H. A., Diamant, M., Guigas, B., & Ouwens, D. M. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.06.002 · Cited by 66
Unraveling the functions of the membrane‐bound glucocorticoid receptors: first clues on origin and functional activity
Strehl, C., & Buttgereit, F. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12364 · Cited by 63
11β-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets
Swali, A., Walker, E. A., Lavery, G. G., Tomlinson, J., & Stewart, P. M. (2008) · Diabetologia · doi:10.1007/s00125-008-1137-2 · Cited by 63
Non-parallelism of islet amyloid polypeptide (amylin) and insulin gene expression in rat islets following dexamethasone treatment
Mulder, H., Ahr�n, B., Stridsberg, M., & Sundler, F. (1995) · Diabetologia · doi:10.1007/bf00410276 · Cited by 61
Current use of glucocorticoids in patients with rheumatoid arthritis in Germany
Thiele, K., Buttgereit, F., Huscher, D., & Zink, A. (2005) · Arthritis Care & Research · doi:10.1002/art.21467 · Cited by 61
Effects of Low-Dose Prednisolone on Hepatic and Peripheral Insulin Sensitivity, Insulin Secretion, and Abdominal Adiposity in Patients With Inflammatory Rheumatologic Disease
Petersons, C. J., Mangelsdorf, B. L., Jenkins, A. B., Poljak, A., Smith, M., Greenfield, J. R., Thompson, C. H., & Burt, M. G. (2013) · Diabetes Care · doi:10.2337/dc12-2617 · Cited by 61
β-cell adaptation in a mouse model of glucocorticoid-induced metabolic syndrome
Fransson, L., Franzén, S., Rosengren, V., Wolbert, P., Sjöholm, Å., & Ortsäter, H. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0189 · Cited by 59
The Heat Shock Protein 70 Cochaperone Hip Enhances Functional Maturation of Glucocorticoid Receptor
Nelson, G. M., Prapapanich, V., Carrigan, P. E., Roberts, P. J., Riggs, D. L., & Smith, D. F. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0054 · Cited by 57
Nutrient regulation of glucagon secretion: involvement in metabolism and diabetes
Marroquí, L., Alonso‐Magdalena, P., Merino, B., Fuentes, E., Nadal, Á., & Quesada, I. (2014) · Nutrition Research Reviews · doi:10.1017/s0954422414000031 · Cited by 57
Prevention of dexamethasone-induced insulin resistance by metformin
Thomas, C. R., Turner, S. L., Jefferson, W., & Bailey, C. J. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00151-8 · Cited by 55
Prolactin, progesterone, and dexamethasone coordinately and adversely regulate glucokinase and cAMP/PDE cascades in MIN6 β-cells
Shao, J., Qiao, L., & Friedman, J. E. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00210.2003 · Cited by 55
Relationship between serum osteocalcin and glycaemic variability in Type 2 diabetes
Bao, Y., Zhou, M., Zhou, J., Lu, W., Gao, Y., Pan, X., Tang, J., Lu, H., & Jia, W. (2010) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2010.05463.x · Cited by 54
The adaptive compensations in endocrine pancreas from glucocorticoid‐treated rats are reversible after the interruption of treatment
Rafacho, A., Quallio, S., Ribeiro, D. L., Taboga, S. R., de Paula, F. M. M., Boschero, A. C., & Bosqueiro, J. R. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02146.x · Cited by 51
Dexamethasone suppresses phospholipase C activation and insulin secretion from isolated rat islets
Zawalich, W. S., Tesz, G. J., Yamazaki, H., Zawalich, K. C., & Philbrick, W. M. (2005) · Metabolism · doi:10.1016/j.metabol.2005.06.023 · Cited by 51
Risk factors for steroid diabetes in rheumatic patients.
Ariza-Andraca, C. R., Barile-Fabris, L. A., Frati-Munari, A. C., & Baltazár-Montufar, P. (1998) · PubMed · Cited by 50
Exogenous Glucocorticoids and a High-Fat Diet Cause Severe Hyperglycemia and Hyperinsulinemia and Limit Islet Glucose Responsiveness in Young Male Sprague-Dawley Rats
Beaudry, J. L., D'souza, A. M., Teich, T., Tsushima, R. G., & Riddell, M. C. (2013) · Endocrinology · doi:10.1210/en.2012-2114 · Cited by 47
Effect of dexamethasone on insulin sensitivity, islet amyloid polypeptide and insulin secretion in humans
Ludvik, B. H., Clodi, M., Kautzky‐Willer, A., Capek, M., Hartter, E., Pacini, G., & Prager, R. (1993) · Diabetologia · doi:10.1007/bf00399099 · Cited by 45
Short-term prednisone use antagonizes insulin's anabolic effect on muscle protein and glucose metabolism in young healthy people
Short, K. R., Bigelow, M. L., & Nair, K. S. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00345.2009 · Cited by 43
Impairment of Rat Fetal Beta-Cell Development by Maternal Exposure to Dexamethasone during Different Time-Windows
Dumortier, O., Theys, N., Ahn, M., Remacle, C., & Reusens, B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025576 · Cited by 41
Insulin release after acute hydrocortisone treatment in mice
Longano, C. A., & Fletcher, H. P. (1983) · Metabolism · doi:10.1016/0026-0495(83)90031-8 · Cited by 40
Changes in Insulin Secretion and Glucose Metabolism Induced by Dexamethasone in Lean and Obese Females
Besse, C., Nicod, N., & Tappy, L. (2005) · Obesity Research · doi:10.1038/oby.2005.41 · Cited by 40
Beta Cell Adaptation to Dexamethasone-Induced Insulin Resistance in Rats Involves Increased Glucose Responsiveness but not Glucose Effectiveness
Karlsson, S., stlund, B. R., Myrsén-Axcrona, U., Sundler, F., & Ahr�n, B. (2001) · Pancreas · doi:10.1097/00006676-200103000-00007 · Cited by 40
Influence of elevated liver fat on circulating adipocytokines and insulin resistance in obese H ispanic adolescents
Kim, J. S., Lê, K., Mahurkar‐Joshi, S., Davis, J. N., & Goran, M. I. (2012) · Pediatric Obesity · doi:10.1111/j.2047-6310.2011.00014.x · Cited by 38
Dexamethasone increases glucose cycling, but not glucose production, in healthy subjects
Wajngot, A., Khan, A. W., Giacca, A., Vranić, M., & Efendić, S. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.259.5.e626 · Cited by 37
Amylin-insulin relationships in insulin resistance with and without diabetic hyperglycemia
Pieber, T. R., Stein, D. T., Ogawa, A., Alam, T., Ohneda, M., McCorkle, K., Chen, L., McGarry, J., & Unger, R. H. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.3.e446 · Cited by 35
Islet-cell dysfunction induced by glucocorticoid treatment: potential role for altered sympathovagal balance?
van Raalte, D. H., Kwa, K. A. A., van Genugten, R. E., Tushuizen, M. E., Holst, J. J., Deacon, C. F., Karemaker, J. M., Heine, R. J., Mari, A., & Diamant, M. (2012) · Metabolism · doi:10.1016/j.metabol.2012.10.007 · Cited by 34
Plasma leptin and ghrelin in the neonatal rat: interaction of dexamethasone and hypoxia
Bruder, E. D., Jacobson, L., & Raff, H. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.06159 · Cited by 33
Insufficient adaptive capability of pancreatic endocrine function in dexamethasone-treated ageing rats
Novelli, M., Tata, V. D., Bombara, M., Lorenzini, A., Masini, M., Pollera, M., Bergamini, E., & Masiello, P. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1620425 · Cited by 32
Evidence that autonomic mechanisms contribute to the adaptive increase in insulin secretion during dexamethasone-induced insulin resistance in humans
Åhrén, B. (2008) · Diabetologia · doi:10.1007/s00125-008-0995-y · Cited by 31
Differential expression of rat pancreatic islet Beta-cell glucose transporter (GLUT 2), proinsulin and islet amyloid polypeptide genes after prolonged fasting, insulin-induced hypoglycaemia and dexamethasone treatment
Koranyi, L. I., Bourey, R. E., TURK, J. W., Mueckler, M. M., & Permutt, M. A. (1992) · Diabetologia · doi:10.1007/bf00401365 · Cited by 31
Glucocorticoid treatment and impaired mood, memory and metabolism in people with diabetes: the Edinburgh Type 2 Diabetes Study
Reynolds, R. M., Labad, J., Sears, A. V., Williamson, R. M., Strachan, M. W. J., Deary, I. J., Lowe, G. D. O., Price, J. F., Walker, B. R., & the Edinburgh Type 2 Diabetes study investigators (2012) · European Journal of Endocrinology · doi:10.1530/eje-12-0041 · Cited by 31
N-acetylcysteine protects pancreatic islet against glucocorticoid toxicity
Roma, L. P., de Oliveira, C. A. M., Carneiro, E. M., de Albuquerque, G. G., Boschero, A. C., & Souza, K. L. A. (2011) · Redox Report · doi:10.1179/1351000211y.0000000006 · Cited by 29
Investigation of the mechanisms contributing to the compensatory increase in insulin secretion during dexamethasone-induced insulin resistance in rhesus macaques
Cummings, B. P., Bremer, A. A., Kieffer, T. J., D’Alessio, D. A., & Havel, P. J. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0459 · Cited by 29
Glucocorticoids regulate somatostatin peptide and steady state messenger ribonucleic acid levels in normal rat tissues and in a somatostatin-producing islet tumor cell line (1027B2).
Papachristou, D. N., Liu, J., & Patel, Y. (1994) · Endocrinology · doi:10.1210/endo.134.5.7908873 · Cited by 28
Plasma prednisolone levels in man following administration in plain and enteric‐coated forms.
WILSON, C., May, C., & Paterson, J. (1977) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1977.tb00723.x · Cited by 27
Involvement of the cholinergic pathway in glucocorticoid-induced hyperinsulinemia in rats
Angelini, N., Rafacho, A., Boschero, A. C., & Bosqueiro, J. R. (2009) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2009.11.008 · Cited by 27
Enhanced glucagon secretion by pancreatic islets from prednisolone-treated mice
Marco, J., Calle, C., HEDO, J. A., & Villanueva, M. L. (1976) · Diabetologia · doi:10.1007/bf00420973 · Cited by 23
Tissue Culture of Fetal Rat Islets: Corticosterone Promotes D Cell Maintenance and Function*
McEvoy, R. C., Leung, P. E., & Goggins, J. A. (1981) · Endocrinology · doi:10.1210/endo-108-6-2277 · Cited by 22
High incidence rate of vertebral fractures during chronic prednisone treatment, in spite of bisphosphonate or alfacalcidol use. Extension of the alendronate or alfacalcidol in glucocorticoid-induced osteoporosis-trial.
Hoes, J. N., Jacobs, J. W. G., Hulsmans, H. M. J., de Nijs, R. N. J., Lems, W. F., Bruyn, G. A., Geusens, P., & Bijlsma, J. W. J. (2010) · PubMed · Cited by 20
Dissecting the Role of Glucocorticoids on Pancreas
Herrera, P. L., Duchêne, B., Czernichow, P., & Bréant, B. (2004) · Cited by 19
The pharmacokinetics of fluocortolone and prednisolone after intravenous and oral administration.
Täuber, U., Haack, D., Nieuweboer, B., Kloss, G., Vecsei, P., & Wendt, H. (1984) · PubMed · Cited by 18
Regulation of Glucocorticoid Receptor Signaling and the Diabetogenic Effects of Glucocorticoid Excess
Ortsäter, H., Sjöholm, Å., & Rafacho, A. (2012) · InTech eBooks · doi:10.5772/51759 · Cited by 17
Acute effects of hydrocortisone on the metabolic response to a glucose load: increase in the first-phase insulin secretion
Vila, G., Krebs, M., Riedl, M., Baumgartner-Parzer, S. M., Clodi, M., Maier, C., Pacini, G., & Luger, A. (2010) · European Journal of Endocrinology · doi:10.1530/eje-10-0282 · Cited by 16
Increased incidence of pre-diabetes mellitus at a department of rheumatology: a retrospective study
Origuchi, T., Yamaguchi, S., Inoue, A., Kazaura, Y., Matsuo, N., Abiru, N., Kawakami, A., & Eguchi, K. (2011) · Modern Rheumatology · doi:10.1007/s10165-011-0433-8 · Cited by 14
Treatment with Growth Hormone
Siguero, L. O. P., Aedo, M., Moreno, L. O. P., & Valverde, M. (2008) · Hormone Research · doi:10.1159/000184669 · Cited by 12
Glucocorticoids regulate somatostatin peptide and steady state messenger ribonucleic acid levels in normal rat tissues and in a somatostatin-producing islet tumor cell line (1027B2)
Papachristou, D. N. (1994) · Endocrinology · doi:10.1210/en.134.5.2259 · Cited by 12
pancreatic b-cells
Kang, G., Chepurny, O. G., & Holz, G. G. (2001) · Cited by 3

Research works printed but not linked: 18

1984, American Journal of Physiology -- Legacy Content, 247, E592
Brown, 1993, Endocrinology, 132, 2614, 10.1210/en.132.6.2614 · DOI · Paper page
Hoes, 2010, Clinical and experimental rheumatology, 28, 354
1992, American Journal of Physiology -- Legacy Content, 263, E663
2014, Endocrinology, 27, 48
2011, MODERN RHEUMATOLOGY, 21, 495, 10.3109/s10165-011-0433-8 · DOI
1994, JOURNAL OF CLINICAL ENDOCRINOLOGY, 79, 820
1994, JOURNAL OF CLINICAL ENDOCRINOLOGY, 78, 1354
1993, American Journal of Physiology -- Legacy Content, 265, E446
1993, JOURNAL OF CLINICAL ENDOCRINOLOGY, 77, 1180
1998, American Journal of Physiology -- Legacy Content, 275, E806
1994, Journal of liposome research, 35, 1535
2008, NATURE CLINICAL PRACTICE RHEUMATOLOGY, 4, 525
1990, American Journal of Physiology -- Legacy Content, 258, E748
T uber, 1984, International journal of clinical pharmacology, therapy, and toxicology, 22, 48
1990, American Journal of Physiology -- Legacy Content, 259, E626
1992, PNAS, 89, 35
2013, Journal of Molecular Endocrinology, 19, R35

Sorted by citations

The crucial role and mechanism of insulin resistance in metabolic disease
Zhao, X., An, X., Yang, C., Sun, W., Ji, H., & Lian, F. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1149239 · Cited by 675
Fresh insights into glucocorticoid-induced diabetes mellitus and new therapeutic directions
Li, J.-X., & Cummins, C. L. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00683-6 · Cited by 285
Glucocorticoids and bone: consequences of endogenous and exogenous excess and replacement therapy
Hardy, R. S., Zhou, H., Seibel, M. J., & Cooper, M. S. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00097 · Cited by 258
Role of cadmium and arsenic as endocrine disruptors in the metabolism of carbohydrates: Inserting the association into perspectives
Sabir, S., Akash, M. S. H., Fiayyaz, F., Saleem, U., Mehmood, M. H., & Rehman, K. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108802 · Cited by 165
Glucocorticoid Signaling: An Update from a Genomic Perspective
Sacta, M. A., Chinenov, Y. V., & Rogatsky, I. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105323 · Cited by 155

See all 216

Authors: Rafacho, A., Ortsäter, H., Nadal, A., & Quesada, I.
Affiliations: Universitat de Miguel Hernández d'Elx (ES)
ORCID: Rafacho, Alex
Ortsäter, Henrik
Venue: Journal of Endocrinology
Publisher: Bioscientifica
Published: 2014-09-30
Volume: 223
Issue: 3
Pages: R49-R62
ISSN: 0022-0795 (ISSN-L)
1479-6805
DOI: 10.1530/joe-14-0373
OpenAlex: W2170071103
Cited by: 216
References: 124
Citations by year: 2026: 7 · 2025: 11 · 2024: 21 · 2023: 14 · 2022: 19 · 2021: 18 · 2020: 18 · 2019: 27 · 2018: 27 · 2017: 16 · 2016: 22 · 2015: 15 · 2014: 1
FWCI: 3.40
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Endocrinology (publishedVersion)
PubMed (publishedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
Funders: European Foundation for the Study of Diabetes
Conselho Nacional de Desenvolvimento Científico e Tecnológico (471397/2011-3)
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
Instituto de Salud Carlos III
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: glucocorticoids, diabetogenic effect, glucose homeostasis, insulin resistance, beta-cell function, hyperinsulinemia, hyperglycemia, hyperglucagonaemia, islet hormones, somatostatin, amylin, ghrelin, osteocalcin, abdominal obesity, insulin signaling
MeSH terms: Animals, Blood Glucose, Diabetes Mellitus, Type 2, Glucocorticoids, Glucose, Homeostasis, Humans, Insulin Resistance, Islets of Langerhans, Models, Biological

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Glucocorticoid treatment and endocrine pancreas function: implications for glucose homeostasis, insulin resistance and diabetes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks