Role of the angiotensin II system in regulation of ovulation and blood flow in the rat ovary
Open accessAbstract
The aim of the present study was to examine the roles of the angiotensin II receptor subtypes, AT(1) and AT(2), in ovulation, and to evaluate the contribution of angiotensin II-mediated pathways in regulation of ovarian blood flow. The AT(1)-specific antagonist, losartan, was administered alone or in combination with the AT(2)-specific antagonist, PD123319, to preovulatory rat ovaries perfused in vitro. Losartan (100 micromol l(-1)) did not affect the number of ovulations, whereas the combination of losartan (100 micromol l(-1)) and PD123319 (10 micromol l(-1)) inhibited ovulation. The angiotensin II antagonists did not affect the ovarian production of oestradiol, progesterone, prostaglandin E(2) (PGE(2)), PGF(2 alpha) or plasminogen activator activity. Ovarian nitric oxide production was inhibited by losartan. Ovarian blood flow was measured by laser Doppler flowmetry in vivo in preovulatory rat ovaries. Intrabursal injection of angiotensin II reduced ovarian blood flow of gonadotrophin-stimulated rats. Losartan had no effect on basal ovarian blood flow but completely blocked the angiotensin II-induced reduction. In contrast, treatment with PD123319 increased basal ovarian blood flow and failed to reverse the effect of exogenously administered angiotensin II, indicating that under physiological conditions, ovarian blood flow of the rat is negatively regulated by angiotensin II mainly through the action of AT(2). Taken together, these results indicate that two different types of angiotensin II receptor facilitate ovulation by cooperative mechanisms and that they regulate ovarian blood flow in a different manner.
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The activity of intrafollicular AngII may facilitate oocyte maturation, ovulation, and corpus luteum regression.
“Consistenting with previous reports, the activity of intrafollicular AngII may facilitate oocyte maturation [39], ovulation [40], and corpus luteum regression [41].”
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“Con-sistenting with previous reports, the activity of intra-follicular AngII may facilitate oocyte maturation [39], ovulation [40], and corpus luteum regression [41].”
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RECEPTOR DE ANGIOTENSINA II ENVOLVIDO NA REGULAÇÃO DA MATURAÇÃO NUCLEAR DE OÓCITO BOVINO
Benetti, L. B. (2008) · Americanae (AECID Library)
Hannon, P. R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-21477-6.00139-5
- Authors
- Mitsube, K., Mikuni, M., Matousek, M., Zackrisson, U., & Brannstrom, M.
- Affiliations
- Hokkaido University (JP)
- University of Gothenburg (SE)
- ORCID
- Mitsube, K
- Venue
- Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-03-01
- Volume
- 125
- Issue
- 3
- Pages
- 425-435
- ISSN
- 1470-1626 (ISSN-L)
- 1741-7899
- OpenAlex
- W2148582752
- Cited by
- 22
- References
- 36
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2021: 1 · 2018: 1 · 2013: 2
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- angiotensin II, ovulation, ovarian blood flow, losartan, PD123319, nitric oxide, estradiol, progesterone, prostaglandins, plasminogen activator, rats
- MeSH terms
- Angiotensin II, Animals, Drug Synergism, Female, Imidazoles, Ovary, Ovulation, Plasminogen Activators, Pyridines, Regional Blood Flow, Dinoprostone, Laser-Doppler Flowmetry, Rats, Sprague-Dawley, Losartan, Rats, Angiotensin Receptor Antagonists
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