Role of angiotensin in ovarian follicular development and ovulation in mammals: a review of recent advances
Open accessAbstract
Angiotensin (Ang) II is widely known for its role in the control of systemic blood vessels. Moreover, Ang II acts on the vascular control of ovarian function, corpus luteum formation, and luteolysis. Over the past 10 years, our research group has been studying the new concept of the renin–angiotensin system (RAS) as an autocrine/paracrine factor regulating steroidogenesis and promoting different cellular responses in the ovary, beyond vascular function. We have developed and used different in vivo and in vitro experimental models to study the role of RAS in the ovary and a brief overview of our findings is presented here. It is widely accepted that there are marked species differences in RAS function in follicle development. Examples of species-specific functions of the RAS in the ovary include the involvement of Ang II in the regulation of follicle atresia in rats vs the requirement of this peptide for the dominant follicle development and ovulation in rabbits and cattle. More recently, Ang-(1–7), its receptor, and enzymes for its synthesis (ACE2, NEP, and PEP) were identified in bovine follicles, implying that Ang-(1–7) has an ovarian function. Other novel RAS components (e.g. (pro)renin receptor and renin-binding protein) recently identified in the bovine ovary show that ovarian RAS is poorly understood and more complex than previously thought. In the present review, we have highlighted the progress toward understanding the paracrine and autocrine control of ovarian antral follicle development and ovulation by ovarian tissue RAS, focusing on in vivo studies using cattle as a model.
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There is a local RAS in the human ovary that plays a key role.
“Recently, it has been found that there is a local Renin–angiotensin system (RAS) in human ovary and it plays a key role.”
From Transplantation of human umbilical cord-derived mesenchymal stem cells improves age-related ovarian functional decline via regulating the local renin–angiotensin system on inflammation and oxidative stress (2024) · cites this paper as [7]
The Ovarian RAS and Summary and conclusion sections describe a local ovarian RAS involved in ovarian physiology. The Regulation of RAS members during follicle development section reports angiotensin findings in women, but the review emphasizes species differences and does not establish that this system plays a key role specifically in the human ovary. Page numbers were not available in our copy. (LLM, conf=0.83)
Experimental — accuracy not yet measuredThe local RAS is a complex network of precursors, peptides, enzymes and receptors involved in regulating ovarian function, oogenesis and ovarian diseases via paracrine and autocrine.
“The local RAS emphasizes a complex network of precursors, peptides, enzymes and receptors [5], which is involved in regulating ovarian function, oogenesis and ovarian diseases or abnormalities via paracrine and autocrine [6, 7].”
From Transplantation of human umbilical cord-derived mesenchymal stem cells improves age-related ovarian functional decline via regulating the local renin–angiotensin system on inflammation and oxidative stress (2024) · cites this paper as [7]
The Introduction and Summary and conclusion (pages not supplied) describe ovarian RAS as a complex system of peptides, enzymes and receptors involved in autocrine/paracrine regulation of follicular development and ovulation. The passages support its role in ovarian physiology, but do not establish the broader claims about regulating oogenesis or ovarian diseases and abnormalities. (LLM, conf=0.83)
Experimental — accuracy not yet measuredIn the human ovary, local RAS is involved in supporting oogenesis, regulating ovulation function, synthesizing steroid hormones, and mediating gonadotropin function.
“In the human ovary, local RAS is involved in many important physiological processes such as supporting oogenesis, regulating ovulation function, synthesizing steroid hormones, and mediating gonadotropin function [7, 23–25].”
From Transplantation of human umbilical cord-derived mesenchymal stem cells improves age-related ovarian functional decline via regulating the local renin–angiotensin system on inflammation and oxidative stress (2024) · cites this paper as [7]
The Introduction and the sections on follicle development and ovulation describe ovarian RAS roles in follicle development, ovulation, steroidogenesis, and mediation of LH action. The human observations in “Regulation of RAS members during follicle development” show associations with gonadotropin treatment and estradiol, but the functional evidence is chiefly from cattle, rabbits, and rodents. The review does not establish all four claimed functions, particularly support of oogenesis, in the human ovary. Page numbers are unavailable in our copy. (LLM, conf=0.88)
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Local Renin-Angiotensin System in the Reproductive System
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“In the human ovary, local RAS is involved in many important physiological processes such as supporting oogenesis, regulating ovulation function, synthesizing steroid hormones, and mediating gonadotropin function [7, 23–25].”
Background
- Authors
- Gonçalves, P. B., Ferreira, R., Gasperin, B., & Oliveira, J. F.
- Affiliations
- Universidade Federal de Santa Maria (BR)
- Venue
- Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-01-01
- Volume
- 143
- Issue
- 1
- Pages
- 11-20
- ISSN
- 1470-1626 (ISSN-L)
- 1741-7899
- OpenAlex
- W2145967063
- Cited by
- 57
- References
- 80
- Citations by year
- 2025: 4 · 2024: 8 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 6
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Funders
- McGill University
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidade Federal de Santa Catarina
- Universidade Federal de Minas Gerais
- Universidade Estadual Paulista
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Reproductive Physiology in Livestock
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- angiotensin II, renin-angiotensin system, ovarian follicle development, ovulation, angiotensin-(1-7), ACE2, neprilysin, prorenin receptor, renin-binding protein, steroidogenesis, follicular atresia, dominant follicle, cattle, paracrine signaling, autocrine signaling
- MeSH terms
- Angiotensin I, Angiotensin II, Animals, Cattle, Female, Ovarian Follicle, Models, Biological, Ovulation, Peptide Fragments, Rabbits, Receptors, Angiotensin, Renin-Angiotensin System, Signal Transduction, Autocrine Communication, Paracrine Communication, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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