Characterization of Chicken MMP13 Expression and Genetic Effect on Egg Production Traits of Its Promoter Polymorphisms
Open accessAbstract
Extracelluar matrix undergoes constant remodeling, cell-cell, and cell-matrix interactions during chicken ovarian follicle growth, which is coordinated by matrix metalloproteinases (MMPs), and their associated endogenous inhibitors (TIMPs). Transcriptome analysis revealed upregulation of MMP13 in sexually mature chicken ovaries. In this study, we found that the expression of MMP13 in chicken ovary was stably elevated from 60 d to 159 d, and was significantly higher at 159 d than at the other three developmental stages (P < 0.05). The expression of MMP13 mRNA increased from SW (small white follicles) to F5 (fifth largest follicles), then decreased to F1 (first largest follicles), and dramatically increased again in POF1 (newly postovulatory follicles) follicles (P < 0.05). The MMP13 protein was localized in stroma cells and primordial follicles of sexually immature chicken ovaries, in the theca cell layers of all sized follicles of sexually mature chicken ovaries. Furthermore, we identified a positive element (positions -1863 to -1036) controlling chicken MMP13 transcription, and, in this region, six single nucleotide polymorphisms were found and genotyped in chicken populations. In the White Recessive Rock population, hens with A(-1356)-C(-1079)/A(-1356)-C(-1079) genotype had earlier "age at first laying" than those with G(-1356)-T(-1079)/G(-1356)-T(-1079) genotype (P < 0.05), and exhibited significantly lower transcriptional activity (P < 0.01). Collectively, chicken MMP13 plays an important role in ovarian follicle growth and regression, and polymorphisms in its promoter region could be used as molecular markers for improving the trait "age at first laying" in chicken breeding.
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PGR and MMP13 function in poultry fertility.
“which function in poultry fertility (Shen et al. 2016; Yuan et al. 2016)”
From Genomic Analyses Unveil Helmeted Guinea Fowl (<i>Numida meleagris</i>) Domestication in West Africa (2021) · cites this paper as Yuan et al. 2016
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Genomic Analyses Unveil Helmeted Guinea Fowl (<i>Numida meleagris</i>) Domestication in West Africa
Shen, Q.-K., Peng, M.-S., Adeola, A. C., Kui, L., Duan, S., Miao, Y.-W., Eltayeb, N. M., Lichoti, J. K., Otecko, N. O., Strillacci, M. G., et al. (2021) · Genome Biology and Evolution · doi:10.1093/gbe/evab090 · Cited by 13 · see citing works
- Authors
- Yuan, Z., Chen, Y., Chen, Q., Guo, M., Kang, L., Zhu, G., & Jiang, Y.
- Affiliations
- Shandong Agricultural University (CN)
- Taishan University (CN)
- Corresponding author
- Jiang, Yunliang
- Venue
- G3 Genes Genomes Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-05-01
- Volume
- 6
- Issue
- 5
- Pages
- 1305-1312
- ISSN
- 2160-1836 (ISSN-L)
- PMC
- PMC4856082
- OpenAlex
- W2406273446
- Cited by
- 16
- References
- 38
- Citations by year
- 2024: 3 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- G3 Genes Genomes Genetics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Science Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Reproductive Physiology in Livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- MMP-13, chickens, promoter polymorphism, single nucleotide polymorphisms, egg production traits, ovarian follicle development, extracellular matrix remodeling, matrix metalloproteinases, theca cells, primordial follicles, transcriptional activity, genetic markers
- MeSH terms
- Animals, Chickens, Eggs, Female, Ovarian Follicle, Immunohistochemistry, Ovary, Polymorphism, Genetic, Promoter Regions, Genetic, Reproduction, Linkage Disequilibrium, Gene Expression, Sequence Deletion, Quantitative Trait, Heritable, Matrix Metalloproteinase 13
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