A Combinatorial Interplay Among the 1-Aminocyclopropane-1-Carboxylate Isoforms Regulates Ethylene Biosynthesis in Arabidopsis thaliana
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Ethylene (C(2)H(4)) is a unique plant-signaling molecule that regulates numerous developmental processes. The key enzyme in the two-step biosynthetic pathway of ethylene is 1-aminocyclopropane-1-carboxylate synthase (ACS), which catalyzes the conversion of S-adenosylmethionine (AdoMet) to ACC, the precursor of ethylene. To understand the function of this important enzyme, we analyzed the entire family of nine ACS isoforms (ACS1, ACS2, ACS4-9, and ACS11) encoded in the Arabidopsis genome. Our analysis reveals that members of this protein family share an essential function, because individual ACS genes are not essential for Arabidopsis viability, whereas elimination of the entire gene family results in embryonic lethality. Phenotypic characterization of single and multiple mutants unmasks unique but overlapping functions of the various ACS members in plant developmental events, including multiple growth characteristics, flowering time, response to gravity, disease resistance, and ethylene production. Ethylene acts as a repressor of flowering by regulating the transcription of the FLOWERING LOCUS C. Each single and high order mutant has a characteristic molecular phenotype with unique and overlapping gene expression patterns. The expression of several genes involved in light perception and signaling is altered in the high order mutants. These results, together with the in planta ACS interaction map, suggest that ethylene-mediated processes are orchestrated by a combinatorial interplay among ACS isoforms that determines the relative ratio of homo- and heterodimers (active or inactive) in a spatial and temporal manner. These subunit isoforms comprise a combinatorial code that is a central regulator of ethylene production during plant development. The lethality of the null ACS mutant contrasts with the viability of null mutations in key components of the ethylene signaling apparatus, strongly supporting the view that ACC, the precursor of ethylene, is a primary regulator of plant growth and development.
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ACC-deaminase activity lowers the levels of stress ethylene improving plant growth in stress conditions.
“ACC-deaminase activity lowers the levels of stress ethylene improving plant growth in stress conditions (Glick et al., 1998;Contesto et al., 2008;Tsuchisaka et al., 2009;Bulgarelli et al., 2013).”
From Intensify production, transform biomass to energy and novel goods and protect soils in Europe—A vision how to mobilize marginal lands (2018) · cites this paper as Tsuchisaka et al., 2009
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Novo‐Uzal, E., Fernández-Pérez, F., Herrero, J., Gutiérrez, J., Ros, L. V. G., Bernal, M. Á., Dı́az, J., Cuello, J., Pomar, F., & Pedreño, M. A. (2013) · Journal of Experimental Botany · doi:10.1093/jxb/ert221 · Cited by 56 · see citing works
- Authors
- Tsuchisaka, A., Yu, G., Jin, H., Alonso, J. M., Ecker, J. R., Zhang, X., Gao, S., & Theologis, A.
- Affiliations
- Plant Gene Expression Center (US)
- University of California, Riverside (US)
- Salk Institute for Biological Studies , La Jolla, California 92037
- Salk Institute for Biological Studies (US)
- Plant Gene Expression Center , Albany, California 94710
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-11-01
- Volume
- 183
- Issue
- 3
- Pages
- 979-1003
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- PMC
- PMC2778992
- OpenAlex
- W2104743494
- Cited by
- 309
- References
- 98
- Citations by year
- 2026: 13 · 2025: 15 · 2024: 18 · 2023: 23 · 2022: 28 · 2021: 26 · 2020: 21 · 2019: 16 · 2018: 21 · 2017: 20 · 2016: 10 · 2015: 18 · 2014: 17 · 2013: 20 · 2012: 15
- FWCI
- 17.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Genetics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Postharvest Quality and Shelf Life Management
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Keywords
- 1-aminocyclopropane-1-carboxylate synthase, ethylene production, Arabidopsis thaliana, gene family, embryonic lethality, flowering time, FLOWERING LOCUS C, heterodimerization, protein interaction maps, light signaling, disease resistance, gravity response, plant development
- MeSH terms
- Amino Acids, Cyclic, Epistasis, Genetic, Ethylenes, Genetic Complementation Test, Isoenzymes, Lyases, Mutation, Plant Diseases, S-Adenosylmethionine, Time Factors, Gene Expression Regulation, Enzymologic, Arabidopsis, Gene Expression Regulation, Plant, Gene Expression Regulation, Developmental, Genome, Plant, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling, Arabidopsis Proteins, Plants, Genetically Modified, Flowers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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