The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Estimating Individual Admixture Proportions from Next Generation Sequencing Data
Open accessAbstract
Inference of population structure and individual ancestry is important both for population genetics and for association studies. With next generation sequencing technologies it is possible to obtain genetic data for all accessible genetic variations in the genome. Existing methods for admixture analysis rely on known genotypes. However, individual genotypes cannot be inferred from low-depth sequencing data without introducing errors. This article presents a new method for inferring an individual’s ancestry that takes the uncertainty introduced in next generation sequencing data into account. This is achieved by working directly with genotype likelihoods that contain all relevant information of the unobserved genotypes. Using simulations as well as publicly available sequencing data, we demonstrate that the presented method has great accuracy even for very low-depth data. At the same time, we demonstrate that applying existing methods to genotypes called from the same data can introduce severe biases. The presented method is implemented in the NGSadmix software available at http://www.popgen.dk/software.
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Cites
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Cited by
ANGSD: Analysis of Next Generation Sequencing Data
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Self-citationThe genetic history of Ice Age Europe
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Inferring Population Structure and Admixture Proportions in Low-Depth NGS Data
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Self-citationGenome flux and stasis in a five millennium transect of European prehistory
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The prehistoric peopling of Southeast Asia
McColl, H., Racimo, F., Vinner, L., Demeter, F., Gakuhari, T., Moreno-Mayar, J. V., van Driem, G., Gram Wilken, U., Seguin-Orlando, A., de la Fuente Castro, C., et al. (2018) · Science · doi:10.1126/science.aat3628 · Cited by 517
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Metadata
- Authors
- Skotte, L., Korneliussen, T. S., & Albrechtsen, A.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-11-01
- Volume
- 195
- Issue
- 3
- Pages
- 693-702
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W2145491782
- Cited by
- 717
- References
- 25
- FWCI
- 10.52
- Type
- journal article
- Language
- en
- Open access
- green
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