The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
The Maintenance of Extreme Amino Acid Diversity at the Disease Resistance Gene, RPP13 , in Arabidopsis thaliana
Open accessAbstract
We have used the naturally occurring plant-parasite system of Arabidopsis thaliana and its common parasite Peronospora parasitica (downy mildew) to study the evolution of resistance specificity in the host population. DNA sequence of the resistance gene, RPP13, from 24 accessions, including 20 from the United Kingdom, revealed amino acid sequence diversity higher than that of any protein coding gene reported so far in A. thaliana. A significant excess of amino acid polymorphism segregating within this species is localized within the leucine-rich repeat (LRR) domain of RPP13. These results indicate that single alleles of the gene have not swept through the population, but instead, a diverse collection of alleles have been maintained. Transgenic complementation experiments demonstrate functional differences among alleles in their resistance to various pathogen isolates, suggesting that the extreme amino acid polymorphism in RPP13 is maintained through continual reciprocal selection between host and pathogen.
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Metadata
- Authors
- Rose, L. E., Bittner-Eddy, P. D., Langley, C. H., Holub, E. B., Michelmore, R. W., & Beynon, J. L.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-03-01
- Volume
- 166
- Issue
- 3
- Pages
- 1517-1527
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W2125721380
- Cited by
- 264
- References
- 44
- FWCI
- 8.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Rose, L. E., Bittner-Eddy, P. D., Langley, C. H., Holub, E. B., Michelmore, R. W., & Beynon, J. L. (2004). The Maintenance of Extreme Amino Acid Diversity at the Disease Resistance Gene, RPP13 , in Arabidopsis thaliana. Genetics. https://doi.org/10.1534/genetics.166.3.1517
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
