Destructive Role of TMAO in T-Tubule and Excitation-Contraction Coupling in the Adult Cardiomyocytes
Open accessAbstract
handling dysfunction in cardiomyocytes under the TMAO stress via promoting tubulin densification and polymerization and therefore Junctophilin-2 (JPH2) redistribution. Mice treated with TMAO represented cardiac dysfunction and T-tubule network disorganization.TMAO impairs cardiac function via the promotion of tubulin polymerization, subsequent translocation of JPH2, and T-tubule remodeling, which provides a novel mechanism for the relationship between HF and elevated TMAO.
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Trimethylamine N-oxide has been shown to promote platelet reactivity and thrombosis potential, vascular inflammation and inflammasome activation, and heightened heart failure and chronic kidney disease related phenotypes in animal models.
“It has also been shown to promote platelet reactivity and thrombosis potential14, 83–85, vascular inflammation and inflammasome activation86–88, heightened heart failure89–91 and CKD92–95 related phenotypes in animal models (Figure 2).”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [90]
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Self-citation
- Authors
- Jin, B., Ji, F., Zuo, A., Liu, H., Qi, L., He, Y., Wang, Q., & Zhao, P.
- Affiliations
- Qingdao University (CN)
- The Medical Examination Center of Shandong Province Sanatorium
- Affiliated Hospital of Qingdao University (CN)
- Venue
- International Heart Journal
- Published
- 2020-03-28
- Volume
- 61
- Issue
- 2
- Pages
- 355-363
- ISSN
- 1349-2365 (ISSN-L)
- 1349-3299
- OpenAlex
- W3011247554
- Cited by
- 30
- References
- 43
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 3 · 2020: 4
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- International Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Aldose Reductase and Taurine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
- Keywords
- trimethylamine N-oxide, T-tubules, excitation-contraction coupling, cardiomyocytes, microtubule assembly, junctophilin-2, heart failure, cardiac dysfunction, dietary metabolites
- MeSH terms
- Animals, Calcium, Cells, Cultured, Heart Failure, Male, Membrane Proteins, Methylamines, Mice, Inbred C57BL, Microtubules, Tubulin, Myocytes, Cardiac, Excitation Contraction Coupling
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