Risk Factors for Colorectal Cancer
Open accessAbstract
In this review, modifiable and non-modifiable risk factors that contribute to development of colorectal cancer are discussed, exploring the role of genetics and heritable colon cancer syndromes along with medical comorbidities that influence risk.Socioeconomic factors that contribute to colorectal cancer risk are explored along with various health-related behavioral patterns such as obesity, smoking, and diet.Recent data suggesting changes in the incidence of colorectal cancer in the last decade is also reviewed.The rationale for a long-term population-based exploration of these issues is laid out to identify areas in which intervention can promote healthy behaviors, avoid disease, and optimize treatments.
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The mechanism of the relationship between ulcerative colitis and Crohn's disease with colorectal cancer is explained by the presence of chronic inflammation in the mucosa, which causes an increase in the process of cellular proliferation and the frequency of mutations of epithelial cells in patients with inflammatory bowel disease.
“The mechanism of the relationship between ulcerative colitis and Crohn’s disease with CRC is explained by the presence of chronic inflammation in the mucosa, which causes an increase in the process of cellular proliferation and the frequency of mutations of epithelial cells in patients with IBD[42].”
From Risk factors, prevention and screening of colorectal cancer: A rising problem (2025) · cites this paper as [42]
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- Authors
- Y Peterson, C.
- Venue
- MOJ Surgery
- Publisher
- MedCrave Group Kft.
- Published
- 2015-04-04
- Volume
- 2
- Issue
- 2
- ISSN
- 2379-6162 (ISSN-L)
- OpenAlex
- W2188364846
- Cited by
- 6
- References
- 77
- Citations by year
- 2024: 3 · 2022: 2 · 2021: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- MOJ Surgery (publishedVersion)
- Funders
- Medical College of Wisconsin
- Topics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
- Keywords
- colorectal cancer, risk factors, modifiable risk factors, genetic susceptibility, comorbidities, socioeconomic factors, obesity, smoking, diet, colorectal cancer incidence trends
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