Should central venous catheters be removed as soon as candidemia is detected in neonates

Evidence-Based Medicine: How to Practice and Teach EBM

Sackett, D. L. (2000) · Cited by 5,950

Principles and Practice of Pediatric Infectious Diseases

(2018) · Elsevier eBooks · doi:10.1016/c2013-0-19020-4 · Cited by 753

International Conference for the Development of a Consensus on the Management and Prevention of Severe Candidal Infections

Edwards, Jr., Bodey, G. P., Bowden, R. A., Buchner, T., de Pauw, B. E., Filler, S. G., Ghannoum, M. A., Glauser, M., Herbrecht, R., Kauffman, C. A., et al. (1997) · Clinical Infectious Diseases · doi:10.1086/514504 · Cited by 418

Candida parapsilosis: Epidemiology, Pathogenicity, Clinical Manifestations, and Antimicrobial Susceptibility

Weems, J. J. (1992) · Clinical Infectious Diseases · doi:10.1093/clinids/14.3.756 · Cited by 399

Candidemia in a neonatal intensive care unit: trends during fifteen years and clinical features of 111 cases

KOSSOFF, E. H., BUESCHER, E. S., & KARLOWICZ, M. G. (1998) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-199806000-00014 · Cited by 330

Vascular Catheter-Associated Fungemia in Patients with Cancer: Analysis of 155 Episodes

Lecciones, J. A., Lee, J. W., Navarro, E. E., Witebsky, F. G., Marshall, D., Steinberg, S. M., Pizzo, P. A., & Walsh, T. J. (1992) · Clinical Infectious Diseases · doi:10.1093/clinids/14.4.875 · Cited by 317

Neonatal Therapeutic Intervention Scoring System: A Therapy-Based Severity-of-Illness Index

Gray, J. E., Richardson, D. K., McCormick, M. C., Workman‐Daniels, K., & Goldmann, D. A. (1992) · PEDIATRICS · doi:10.1542/peds.90.4.561 · Cited by 296

Outcome of treatment of candidemia in children whose central catheters were removed or retained.

Sc, E., TROUTMAN, J. L., & Lt, G. (1989) · PubMed · Cited by 180

Candida: An Increasingly Important Pathogen in the Nursery

BUTLER, K. M., & Baker, C. J. (1988) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(16)36471-9 · Cited by 172

Candidemia in children with central venous catheters

Dato, V., & Dajani, A. S. (1990) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-199005000-00002 · Cited by 163

Prognostic factors of candidemia among nonneutropenic adults with total parenteral nutrition

Tsai, C., Lay, C.-J., Wang, C.-L., Lin, M.-L., & Yang, S.-P. (2011) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2011.04.002 · Cited by 8

Candidemia in the pediatric intensive care unit in Eastern India

Mishra, R., Behera, C. K., Jena, P., Mishra, S. N., Sahoo, B., Patnaik, S., & Jain, M. K. (2020) · JOURNAL OF PEDIATRIC CRITICAL CARE · doi:10.4103/jpcc.jpcc_38_20 · Cited by 8

Catheter-Related Infections

(2004) · CRC Press eBooks · doi:10.1201/b14177 · Cited by 8

Early removal versus expectant management of central venous catheters in neonates with bloodstream infection

Vasudevan, C., & McGuire, W. L. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008436.pub2 · Cited by 8

Clinical spectrum, management and outcome of neonatal candidiasis.

Khan, E. A., Choudhry, S., Fatima, M., & Batool, Z. (2015) · PubMed · Cited by 6

Study of strains of Candida spp. Isolated from catheters in UHC of Oran (Algeria): Identification and antifungal susceptibility

Bendjelloul, M., Boucherit‐Otmani, Z., & Boucherit, K. (2016) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2016.02.022 · Cited by 6

Bacterial and Fungal Infections in the Neonate: Current Diagnosis and Therapy

Sánchez, P. J. (2004) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-8993-2_14 · Cited by 6

Neonatal Infectious Diseases

Adams-Chapman, I. S., & Stoll, B. J. (2011) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789814313476_0016 · Cited by 6

Antifungal agents for the treatment of systemic mycoses

Schutze, G. E. (2001) · Seminars in Pediatric Infectious Diseases · doi:10.1053/spid.2001.24105 · Cited by 6

Treatment of Neonatal Fungal Infections

Moran, C., & Benjamin, D. K. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-0981-7_11 · Cited by 5

Assessment of the anti-biofilm effect of micafungin in an animal model of catheter-related candidemia

Salinas, B., Guembe, M., Cussó, L., Kestler, M., Guinea, J., Desco, M., Muñóz, P., & Bouza, E. (2018) · Medical Mycology · doi:10.1093/mmy/myy065 · Cited by 5

Congenital Cutaneous Candidiasis With Systemic Dissemination in a Preterm Infant

Miras, I., Vierge, E., García, M. T., Arruza, L., Criado, E., Ramos, J. T., & Martínez-Orgado, J. A. (2021) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000003080 · Cited by 5

Healthcare-Associated Infections

Srinivasan, L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-82823-9.00037-4 · Cited by 6

Traitement des candidémies chez un patient porteur d’un cathéter vasculaire

Gallien, S., Sordet, F., & Angoulvant, A. (2007) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2006.10.006 · Cited by 5

Survey of neonatal candidiasis in Greece

Dotis, J., Evdoridou, J., Kremenopoulos, G., & Roilides, E. (2005) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-005-0022-x · Cited by 5

Early removal of a permanent catheter during the acute management of the unstable pediatric hemato-oncology patient with suspected catheter-related bloodstream infection: a multi-disciplinary survey and review of the literature

Cohen, N., Rosenberg, T., Rimon, A., & Friedman, S. (2022) · European Journal of Pediatrics · doi:10.1007/s00431-022-04747-7 · Cited by 4

Management of invasive fungal infections in the pediatric intensive care unit

Fisher, B. T., Zaoutis, T. E., & Chiotos, K. (2015) · Journal of Pediatric Intensive Care · doi:10.3233/pic-14108 · Cited by 4

Current Epidemiology and Management of Invasive Candidiasis in Infants

Zimmerman, K. O., & Smith, P. B. (2014) · Current Fungal Infection Reports · doi:10.1007/s12281-013-0167-5 · Cited by 4

Candidiasis

Bendel, C. M. (2006) · Elsevier eBooks · doi:10.1016/b0-72-160537-0/50035-9 · Cited by 4

Neonatal Bacterial and Fungal Infections

Stronati, M., & Borghesi, A. (2012) · Springer eBooks · doi:10.1007/978-88-470-1405-3_116 · Cited by 4

Candidemia en una Unidad de Cuidados Intensivos Neonatales: identificación de factores de riesgo

Pooli, L., Fasolino, M. N., Pereda, R., Rial, M. J., & Califano, G. (2006) · Archivos Argentinos de Pediatria · Cited by 4

Mucocutaneous and Deeply Invasive Candidiasis

Shoham, S., Nucci, M., & Walsh, T. J. (2011) · Elsevier eBooks · doi:10.1016/b978-0-7020-3935-5.00088-4 · Cited by 4

Staphylococcus capitis Central-Line-Associated Bloodstream Infections in the Neonatal Intensive Care Unit: A Single-Center, Four-Year Experience in Central-Line Management during Sepsis Treatment

Sala, A., Pivetti, V., Vittorini, A., Viggiano, C., Castoldi, F. M., Fabiano, V., Lista, G., & Cavigioli, F. (2024) · Pathogens · doi:10.3390/pathogens13030234 · Cited by 3

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Shan, A., Sebastián, M. D. M. S., & Saavedra‐Lozano, J. (2024) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000004457 · Cited by 3

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Bendel, C. M. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-6400-8.00033-x · Cited by 3

Infectious Diseases: Superficial Fungal Infections

Motaparthi, K. (2016) · Springer eBooks · doi:10.1007/978-3-319-43630-2_16 · Cited by 2

Effective Strategies for the Prevention of Nosocomial Sepsis in Extremely Premature Infants

Chang, Y. S. (2009) · Hanyang Medical Reviews · doi:10.7599/hmr.2009.29.4.354 · Cited by 2

Controversies about the management of invasive fungal infections in very low birth weight infants

Moreira, M. E. L. (2005) · Jornal de Pediatria · doi:10.1590/s0021-75572005000200007 · Cited by 16

Neonatal Candida Spp. Infections: An Update

Manzoni, P., Kaufman, D. A., Mostert, M., & Farina, D. (2008) · Pediatric Health · doi:10.2217/17455111.2.1.79 · Cited by 2

Neonatal Fungal Infections

Sims, C. R., & Ostrosky-Zeichner, L. L. (2008) · Elsevier eBooks · doi:10.1016/b978-141603158-1.10015-0 · Cited by 2

Nosocomial Infections in the Neonate

Karlowicz, M. G., & Buescher, E. S. (2008) · Elsevier eBooks · doi:10.1016/b978-0-7020-3468-8.50102-4 · Cited by 2

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Tatte, P. S., & Bhise, P. R. (2018) · International Journal of Current Microbiology and Applied Sciences · doi:10.20546/ijcmas.2018.710.111 · Cited by 1

Early removal versus expectant management of central venous catheters in neonates with bloodstream infection

Vasudevan, C., & McGuire, W. L. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008436 · Cited by 2

InvasiveCandidaInfections in Extremely Preterm Infants

Kim, C. S., & Lee, S. L. (2013) · Neonatal Medicine · doi:10.5385/nm.2013.20.3.369 · Cited by 1

Neonatal Fungal Infections

Ellsworth, M., Sims, C. R., & Ostrosky‐Zeichner, L. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-2662-6.00017-1 · Cited by 1

Fungal Infections in the Neonatal Intensive Care Unit

Hostetter, M. K., & Gleason, C. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-40139-5.00041-3 · Cited by 1

Systemic fungal infections

Seal, P., & Pappas, P. G. (2010) · Elsevier eBooks · doi:10.1016/b978-0-7020-4064-1.00060-9 · Cited by 2

Candida Infections in Hematopoietic and Solid Organ Transplant Recipients

Freifeld, A. G., & Kauffman, C. A. (2019) · Springer eBooks · doi:10.1007/978-1-4939-9034-4_32 · Cited by 1

Neonatal Bacterial and Fungal Infections

Stronati, M., & Borghesi, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-18159-2_254-1 · Cited by 1

Fungal Infections in Neonatal Intensive Care, An Overview

Hamid, N. F., Alsharari, N. M., Aloufi, A. A., Altoonisi, M. M., Alamri, S. A., Alanazi, K. H., Alatawi, A. A., Alsulami, G. M., Alshahrani, H. A., Hamdi, N. H., et al. (2022) · International Journal of Life Science and Pharma Research · doi:10.22376/ijpbs/lpr.2022.12.6.sp24.l17-28

Fungal infections in the neonatal intensive care unit

Hostetter, M. K. (2001) · Seminars in Pediatric Infectious Diseases · doi:10.1053/spid.2001.26637 · Cited by 1

Colonização por Candida em indivíduos com candidemia

Miranda, L. D. N. (2008) · doi:10.11606/d.5.2008.tde-04042008-153349

Strategies for Prevention of Device‐Related Nosocomial Infections

Shunmugaperumal, T. (2010) · Wiley eBooks · doi:10.1002/9780470640463.ch9

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Rodrigues, E. C. D. A. (2009) · doi:10.11606/d.5.2009.tde-05032010-154431

Epidemiologia das infecções de corrente sangüinea de origem hospitalar em hospital de assistência terciária, São Paulo, Brasil

Spir, P. R. N. (2007) · doi:10.11606/d.5.2007.tde-20022009-143433

Reply to Nucci and Anaissie

RAAD, I. I., & Darouiche, R. O. (2005) · Clinical Infectious Diseases · doi:10.1086/428675

From the case records of KKCTH – An infant with failure to thrive and candidial sepsis

Balasubramanian, S., Chandramohan, V., Dhanalakshmi, K., & Amperayani, S. (2014) · Pediatric Infectious Disease · doi:10.1016/j.pid.2014.12.003

Diagnosis and Treatment of Catheter-related Blood Stream Infection in Neonates and Children

Chan, D. (2005)

Australasian guidelines for antifungal therapy in neonates and children with proven, probable and suspected invasive fungal infections

Blyth, C., & Blyth, C. C. (2007)

Fungaemia in the neonatal unit at Chris Hani Baragwanath Hospital: risk factors, aetiology, susceptibility to antifungals and outcome.

Nakwa, F. L. (2012) · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)

Epidemiologia das infecções de corrente sangüínea de origem hospitalar em hospital de assistência

Rodrigues, P., & Spir, N. (2007)

For peer review only Candida parapsilosis candidaemia in a neonatal unit over 7 years: a case series study

Marie, I., Lúcia, V., Augusta, M., & Sara, A. (2012)

Infections mycosiques

Aujard, Y., & Biran, V. (2015) · Elsevier eBooks · doi:10.1016/b978-2-294-74135-7.00011-5

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Aquino, V. R. (2005) · Americanae (AECID Library)

Invasive Candida infections in the nursery: state of the art

Manzoni, P., Castagnola, E., Jacqz-Aigrain, É., Mostert, M., Stronati, M., & Farina, D. (2014) · Signa Vitae · doi:10.22514/sv92.112014.1

ControvØrsias a respeito da sepse fœngica no prØ-termo extremo: profilaxia e esquemas terapŒuticos Controversies about the management of invasive fungal infections in very low birth weight infants

Moreira, M. E. L. (2005)

Infección sistémica por Candida en unidades de cuidados intensivos neonatales Systemic infection by Candida in neonatal intensive care units

Brooks, Y. P., Brooks, I. P., & Pubillones, P. O. P. (2011) · DOAJ (DOAJ: Directory of Open Access Journals)

Fungal Infections

Isaacs, D. (2013) · Wiley eBooks · doi:10.1002/9781118636657.ch16

Hospital-Associated Infections in the Neonate

Karlowicz, M. G., & Sass, L. A. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-2702-9.00096-9

Fungal Infections in the Neonatal Intensive Care Unit

Hostetter, M. K. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0134-0.10041-1

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Guerguis, S., Lee, P., & Goldman, D. L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-809633-8.21024-8

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Stronati, M., & Borghesi, A. (2018) · Springer eBooks · doi:10.1007/978-3-319-29489-6_254

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Drake, S., & Sandoe, J. A. T. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780198755388.003.0021

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Hostetter, M. K. (2005) · Elsevier eBooks · doi:10.1016/b978-072169347-7.50043-3

Candida Species

Smith, P. B., & Steinbach, W. J. (2008) · Elsevier eBooks · doi:10.1016/b978-0-7020-3468-8.50250-9

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Cant, A. J., Gennery, A. R., Russell, A. B., & Isaacs, D. (2012) · Elsevier eBooks · doi:10.1016/b978-0-7020-3479-4.00040-4

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Isaacs, D. (2013) · doi:10.1002/9781118636657.ch6

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Cantey, J. B., & Bizzarro, M. J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-75608-2.00094-x

Supplementary material A: Commentaries

Ainsworth, S. B. (2020) · Oxford University Press eBooks · doi:10.1093/med/9780198840787.005.0001

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Upadhyay, K., & Puia‐Dumitrescu, M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-82823-9.00036-2

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Bendel, C. M., & Swanson, E. C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-79525-8.00044-5

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Brophy‐Williams, S., Ewe, K. Y. H., & Yeoh, D. K. (2024) · Current Infectious Disease Reports · doi:10.1007/s11908-024-00848-6

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Biran, V., Boutillier, B., & Basset, G. (2024) · EMC - Pediatría · doi:10.1016/s1245-1789(24)49749-7

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Kawasaki, K., Sawai, T., Inadomi, Y., Morimitsu, S., Ikeda, T., Yoshioka, S., Matsuo, N., Kadota, J., Yanagihara, K., & Mukae, H. (2025) · Journal of Infection and Chemotherapy · doi:10.1016/j.jiac.2025.102662

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Greenberg, R. G., Fisher, B. T., & Otto, W. R. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-82763-8.00217-x

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Alvira-Arill, G. R., Yarbrough, A. H., Tansmore, J. L., Sierra, C. M., Bashqoy, F., Herrera, O. R., Peters, B. M., & Stultz, J. S. (2025) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.70037

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Gherbawy, Y. A. M. H., Puscasiu, D. A., Baddar, A., Yassein, A. S., & El‐Dawy, E. G. A. (2025) · Clinical Case Reports · doi:10.1002/ccr3.70778

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Rose, D. U. D., Mirotta, N., Dotta, A., Salvatori, G., Ronchetti, M. P., Campogiani, L., Ceccherini‐Silberstein, F., & Iannetta, M. (2026) · Antibiotics · doi:10.3390/antibiotics15010066

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Siqueira, A. C., Ferreira, A. M. M., Silva, S. C. S. B., Sestren, B., Krul, D., de Andrade, D. C. P., Poubel, S. B., Spalanzani, R. N., Ricieri, M. C., Motta, F. D. A., et al. (2026) · Jornal de Pediatria · doi:10.1016/j.jped.2026.101535

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Rodriguez, D., Park, B. J., Almirante, B., Cuenca-Estrella, M., Planes, A. M., Mensa, J., Gimenez, M., Saballs, P., Fridkin, S. K., Rodriguez-Tudela, J. L., et al. (2007) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2007.01758.x · Cited by 76

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Nucci, M., Anaissie, E., Betts, R. F., Dupont, B. F., Wu, C., Buell, D. N., Kovanda, L., & Lortholary, O. (2010) · Clinical Infectious Diseases · doi:10.1086/653935 · Cited by 228

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Nucci, M., Braga, P. R., Nouér, S. A., & Anaissie, E. J. (2018) · The Brazilian Journal of Infectious Diseases · doi:10.1016/j.bjid.2018.10.278 · Cited by 32

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Öncel, E. K., Kara, A., Özsürekçi, Y., Arıkan-Akdağlı, S., Cengiz, A. B., Ceyhan, M., Gür, D., Çelik, M., & Parlakay, A. Ö. (2015) · Mycoses · doi:10.1111/myc.12288 · Cited by 24