Early removal of central venous catheter in patients with candidemia does not improve outcome: analysis of 842 patients from 2 randomized clinical trials
Abstract
BACKGROUND: Patients with candidemia frequently have a central venous catheter (CVC) in place, and its early removal is considered the standard of care. METHODS: We performed a subgroup analysis of 2 phase III, multicenter, double-blind, randomized, controlled trials of candidemia to examine the effects of early CVC removal (within 24 or 48 h after treatment initiation) on the outcomes of 842 patients with candidemia. Inclusion criteria were candidemia, age >16 years, CVC at diagnosis, and receipt of 1 dose of the study drug. Six outcomes were evaluated: treatment success, rates of persistent and recurrent candidemia, time to mycological eradication, and survival at 28 and 42 days. Univariate and multivariate analyses were performed, controlling for potential confounders. RESULTS: In univariate analysis, early CVC removal did not improve time to mycological eradication or rates of persistent or recurrent candidemia but was associated with better treatment success and survival. These benefits were lost in multivariate analysis, which failed to show any beneficial effect of early CVC removal on all 6 outcomes and identified Acute Physiology and Chronic Health Evaluation II score, older age, and persistent neutropenia as the most significant variables. Our findings were consistent across all outcomes and time points (removal within 24 or 48 h and survival at 28 and 42 days). The median time to eradication of candidemia was similar between the 2 study groups. CONCLUSIONS: In this cohort of 842 adults with candidemia followed up prospectively, early CVC removal was not associated with any clinical benefit. These findings suggest an evidence-based re-evaluation of current treatment recommendations.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The investigators found no clinical difference in microbiologic outcomes or mortality in the patient group that had the CVC removed within 48 hours versus those that had it retained for the first 48 hours.
“The investigators found no clinical difference in microbiologic outcomes or mortality in the patient group that had the CVC removed within 48 hours versus those that had it retained for the first 48 hours.”
From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [183]
Cites
De Pauw, B., Walsh, T. J., Donnelly, J. P., Stevens, D. A., Edwards, J. E., Calandra, T., Pappas, P. G., Maertens, J., Lortholary, O., Kauffman, C. A., et al. (2008) · Clinical Infectious Diseases · doi:10.1086/588660 · Cited by 4,917 · see citing works
Self-citationEpidemiology of Invasive Candidiasis: a Persistent Public Health Problem
Pfaller, M. A., & Diekema, D. J. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00029-06 · Cited by 4,174 · cited 1× · see citing works
“Candidemia is a common nosocomial bloodstream infection and is associated with high mortality [1].”
BackgroundMermel, L. A., Allon, M., Bouza, E., Craven, D. E., Flynn, P., O'Grady, N. P., Raad, I. I., Rijnders, B. J. A., Sherertz, R. J., & Warren, D. K. (2009) · Clinical Infectious Diseases · doi:10.1086/599376 · Cited by 3,638 · see citing works
Pappas, P. G., Kauffman, C. A., Andes, D., Benjamin, D. K., Calandra, T. F., Edwards, J. E., Filler, S. G., Fisher, J. F., Kullberg, B.-J., Zeichner, L. O., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/596757 · Cited by 3,191 · see citing works
Comparison of Caspofungin and Amphotericin B for Invasive Candidiasis
Mora-Duarte, J., Betts, R., Rotstein, C., Colombo, A. L., Thompson-Moya, L., Smietana, J., Lupinacci, R., Sable, C., Kartsonis, N., & Perfect, J. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021585 · Cited by 1,380 · see citing works
Self-citationRex, J. H., Bennett, J. E., Sugar, A. M., Pappas, P. G., van der Horst, C. M., Edwards, J. E., Washburn, R. G., Scheld, W. M., Karchmer, A. W., Dine, A. P., et al. (1994) · New England Journal of Medicine · doi:10.1056/nejm199411173312001 · Cited by 1,039 · see citing works
Kuhn, D. M., George, T., Chandra, J., Mukherjee, P. K., & Ghannoum, M. A. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.6.1773-1780.2002 · Cited by 765 · see citing works
Kuse, E.-R., Chetchotisakd, P., da Cunha, C. A., Ruhnke, M., Barrios, C., Raghunadharao, D., Sekhon, J. S., Freire, A., Ramasubramanian, V., Demeyer, I., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60605-9 · Cited by 692 · see citing works
Self-citationMicafungin versus Caspofungin for Treatment of Candidemia and Other Forms of Invasive Candidiasis
Pappas, P. G., Rotstein, C. M. F., Betts, R. F., Nucci, M., Talwar, D., De Waele, J. J., Vazquez, J. A., Dupont, B. F., Horn, D. L., Ostrosky-Zeichner, L., et al. (2007) · Clinical Infectious Diseases · doi:10.1086/520980 · Cited by 638 · see citing works
Self-citationAlmirante, B., Rodríguez-Pardo, D., Park, B. J., Cuenca‐Estrella, M., Planes, A. M., Almela, M., Mensa, J., Sánchez, F., Ayats, J., Giménez, M., et al. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.4.1829-1835.2005 · Cited by 567 · see citing works
Kullberg, B., Sobel, J., Ruhnke, M., Pappas, P., Viscoli, C., Rex, J., Cleary, J., Rubinstein, E., Church, L., Brown, J., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67490-9 · Cited by 521 · see citing works
Rex, J. H., Pappas, P. G., Karchmer, A. W., Sobel, J., Edwards, J. E., Hadley, S., Brass, C., Vazquez, J. A., Chapman, S. W., Horowitz, H. W., et al. (2003) · Clinical Infectious Diseases · doi:10.1086/374850 · Cited by 495 · see citing works
Vascular Catheter-Associated Fungemia in Patients with Cancer: Analysis of 155 Episodes
Lecciones, J. A., Lee, J. W., Navarro, E. E., Witebsky, F. G., Marshall, D., Steinberg, S. M., Pizzo, P. A., & Walsh, T. J. (1992) · Clinical Infectious Diseases · doi:10.1093/clinids/14.4.875 · Cited by 317 · see citing works
Predictors of Adverse Outcome in Cancer Patients with Candidemia
Anaissie, E. J., Rex, J. H., Uzun, Ö., & Vartivarian, S. (1998) · The American Journal of Medicine · doi:10.1016/s0002-9343(98)00030-8 · Cited by 295 · see citing works
Self-citationBrożek, J. L., Akl, E. A., Jaeschke, R., Lang, D. M., Bossuyt, P., Glasziou, P., Helfand, M., Ueffing, E., Alonso‐Coello, P., Meerpohl, J., et al. (2009) · Allergy · doi:10.1111/j.1398-9995.2009.02083.x · Cited by 270 · see citing works
Intravascular Catheter Exchange and Duration of Candidemia
Rex, J. H., Bennett, J. E., Sugar, A. M., Pappas, P. G., Serody, J., Edwards, J. E., Washburn, R. G., NIAID Mycoses Study Group, & Candidemia Study Group (1995) · Clinical Infectious Diseases · doi:10.1093/clinids/21.4.994 · Cited by 252 · see citing works
How Evidence-Based Are the Recommendations in Evidence-Based Guidelines?
McAlister, F. A., van Diepen, S., Padwal, R. S., Johnson, J. A., & Majumdar, S. R. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040250 · Cited by 226 · see citing works
Phillips, P., Shafran, S., Garber, G., Rotstein, C., Smaill, F., Fong, I., Salit, I., Miller, M., Williams, K., Conly, J. M., et al. (1997) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/bf01726360 · Cited by 221 · see citing works
Betts, R. F., Nucci, M., Talwar, D., Gareca, M., Queiroz‐Telles, F., Bedimo, R. J., Herbrecht, R., Ruiz‐Palacios, G., Young, J. H., Baddley, J. W., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/598933 · Cited by 214 · see citing works
Self-citationTreatment-related risk factors for hospital mortality in Candida bloodstream infections
Labelle, A. J., Micek, S. T., Roubinian, N., & Kollef, M. H. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e31818b3477 · Cited by 181 · see citing works
Rabbit Model of Candida albicans Biofilm Infection: Liposomal Amphotericin B Antifungal Lock Therapy
Schinabeck, M. K., Long, L. A., Hossain, M. A., Chandra, J., Mukherjee, P. K., Mohamed, S., & Ghannoum, M. A. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.5.1727-1732.2004 · Cited by 181 · see citing works
Nosocomial Candidemia in Non-Neutropenic Patients at an Italian Tertiary Care Hospital
Luzzati, R., Amalfitano, G., Lazzarini, L., Soldani, F., Bellino, S., Solbiati, M., Danzi, M. C., Vento, S., Todeschini, G., Vivenza, C., et al. (2000) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s100960000325 · Cited by 179 · see citing works
Risk factors for death in patients with candidemia
Nucci, M., Colombo, A. L., Silveira, F., Richtmann, R., Salomão, R., Branchini, M. L., & Spector, N. (1998) · Infection Control & Hospital Epidemiology · doi:10.1086/647743 · Cited by 178 · see citing works
Self-citationShould Vascular Catheters Be Removed from All Patients with Candidemia? An Evidence-Based Review
Nucci, M., & Anaissie, E. (2002) · Clinical Infectious Diseases · doi:10.1086/338714 · Cited by 175 · see citing works
Self-citationManchikanti, L. (2008) · Pain Physician · doi:10.36076/ppj.2008/11/161 · Cited by 157 · see citing works
Pappas, P. G., Rotstein, C. M. F., Rf, B., Nucci, M., Talwar, D., Waele, J. J. D., Jm, D. L. V. V., Dupont, B., Horn, D., Ostrosky‐Zeichner, L., et al. (2008) · Ghent University Academic Bibliography (Ghent University) · Cited by 130 · see citing works
Self-citationWeinberger, M., Leibovici, L., Perez, S., Samra, Z., Ostfeld, I., Levi, I., Bash, E., Turner, D., Goldschmied‐Reouven, A., Regev‐Yochay, G., et al. (2005) · Journal of Hospital Infection · doi:10.1016/j.jhin.2005.02.009 · Cited by 95 · see citing works
Impact of early central venous catheter removal on outcome in patients with candidaemia
Rodriguez, D., Park, B. J., Almirante, B., Cuenca-Estrella, M., Planes, A. M., Mensa, J., Gimenez, M., Saballs, P., Fridkin, S. K., Rodriguez-Tudela, J. L., et al. (2007) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2007.01758.x · Cited by 76 · see citing works
Risk factors for death among cancer patients with fungemia
Nucci, M., Silveira, M. I., Spector, N., Silveira, F., Velasco, E., Akiti, T., Barreiros, G., Derossi, A., Colombo, A. L., & Pulcheri, W. (1998) · Clinical Infectious Diseases · doi:10.1086/514609 · Cited by 69 · see citing works
Self-citationLiu, C. Y., Huang, L. J., Wang, W. S., Chen, T. L., Yen, C. C., Yang, M. H., Hsiao, L. T., Liu, C. Y., Chen, P. M., & Chiou, T. J. (2009) · Journal of Infection · doi:10.1016/j.jinf.2008.12.008 · Cited by 67 · see citing works
Velasco, E., & Bigni, R. (2008) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-008-0546-y · Cited by 59 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Pappas, P. G., Kauffman, C. A., Andes, D. R., Clancy, C. J., Marr, K. A., Ostrosky-Zeichner, L., Reboli, A. C., Schuster, M. G., Vazquez, J. A., Walsh, T. J., et al. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/civ933 · Cited by 4,200 · see citing works
Kullberg, B. J., & Arendrup, M. C. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1315399 · Cited by 1,315 · see citing works
Cornely, O. A., Bassetti, M., Calandra, T., Garbino, J., Kullberg, B. J., Lortholary, O., Meersseman, W., Akova, M., Arendrup, M. C., Arikan-Akdagli, S., et al. (2012) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12039 · Cited by 1,217 · see citing works
Self-citationAndes, D. R., Safdar, N., Baddley, J. W., Playford, G., Reboli, A. C., Rex, J. H., Sobel, J. D., Pappas, P. G., Kullberg, B. J., & for the Mycoses Study Group (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis021 · Cited by 793 · see citing works
ESCMID∗ guideline for the diagnosis and treatment of biofilm infections 2014
Høiby, N., Bjarnsholt, T., Moser, C. E., Bassi, G. L., Coenye, T., Donelli, G., Hall‐Stoodley, L., Holá, V., Imbert, C., Kirketerp‐Møller, K., et al. (2015) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2014.10.024 · Cited by 801 · see citing works
Septic shock attributed to Candida infection: Importance of empiric therapy and source control.
Kollef, M., Micek, S., Hampton, N., Doherty, J. A., & Kumar, A. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis305 · Cited by 477 · see citing works
Incidence, characteristics and outcome of ICU-acquired candidemia in India
Chakrabarti, A., Sood, P., Rudramurthy, S. M., Chen, S., Kaur, H., Capoor, M., Chhina, D., Rao, R., Eshwara, V. K., Xess, I., et al. (2015) · Intensive Care Medicine · doi:10.1007/s00134-014-3603-2 · Cited by 454 · see citing works
Invasive candidiasis as a cause of sepsis in the critically ill patient
Delaloye, J., & Calandra, T. (2013) · Virulence · doi:10.4161/viru.26187 · Cited by 380 · see citing works
Cleveland, A. A., Farley, M. M., Harrison, L. H., Stein, B., Hollick, R., Lockhart, S. R., Magill, S. S., Derado, G., Park, B. J., & Chiller, T. M. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis697 · Cited by 366 · see citing works
Ullmann, A. J., Akova, M., Herbrecht, R., Viscoli, C., Arendrup, M. C., Arikan-Akdagli, S., Bassetti, M., Bille, J., Calandra, T., Castagnola, E., et al. (2012) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12041 · Cited by 334 · see citing works
Self-citationCandida sp. Infections in Patients with Diabetes Mellitus
Rodrigues, C. F., Rodrigues, M. E., & Henriques, M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8010076 · Cited by 337 · see citing works
Puig‐Asensio, M., Padilla, B., Garnacho‐Montero, J., Zaragoza, Ó., Aguado, J. M., Zaragoza, R., Montejo, M., Muñóz, P., Ruíz-Camps, I., Cuenca‐Estrella, M., et al. (2013) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12380 · Cited by 297 · see citing works
A multicenter study of septic shock due to candidemia: Outcomes and predictors of mortality.
Bassetti, M., Righi, E., Ansaldi, F., Merelli, M., Cecilia, T., De Pascale, G., Diaz-Martin, A., Luzzati, R., Rosin, C., Lagunes, L., et al. (2014) · Intensive Care Medicine · doi:10.1007/s00134-014-3310-z · Cited by 284 · see citing works
Survival in neutropenic patients with severe sepsis or septic shock*
Legrand, M. M., Max, A., Peigne, V., Mariotte, É., Canet, E., Debrumetz, A., Lemiale, V., Seguin, A., Darmon, M., Schlemmer, B., et al. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e31822b50c2 · Cited by 280 · see citing works
Invasive fungal infections in solid organ transplant recipients
Gavaldà, J., Meije, Y., Fortün, J., Roilides, E., Saliba, F., Lortholary, O., Muñóz, P., Grossi, P., & Cuenca‐Estrella, M. (2014) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12660 · Cited by 231 · see citing works
Self-citationRajendran, R., Sherry, L., Nile, C. J., Sherriff, A., Johnson, E. M., Hanson, M. F., Williams, C., Munro, C. A., Jones, B. J., & Ramage, G. (2016) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2015.09.018 · Cited by 228 · see citing works
Lebeaux, D., Fernández‐Hidalgo, N., Chauhan, A., Lee, S. J., Ghigo, J., Almirante, B., & Beloin, C. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70266-4 · Cited by 193 · see citing works
Colombo, A. L., Guimarães, T., Sukiennik, T., Pasqualotto, A. C., Andreotti, R., Queiroz‐Telles, F., Nouér, S. A., & Nucci, M. (2014) · Intensive Care Medicine · doi:10.1007/s00134-014-3400-y · Cited by 184 · see citing works
Self-citationInvasive Fungal Infections in Solid Organ Transplant Recipients
Shoham, S., & Marr, K. A. (2012) · Future Microbiology · doi:10.2217/fmb.12.28 · Cited by 176 · see citing works
Epidemiology and treatment approaches in management of invasive fungal infections
Ito, J. I., Kriengkauykiat, Dadwal, S., & Kriengkauykiat (2011) · Clinical Epidemiology · doi:10.2147/clep.s12502 · Cited by 184 · see citing works
Invasive Fungal Infections in the ICU: How to Approach, How to Treat
Paramythiotou, E., Frantzeskaki, F. G., Flevari, A., Armaganidis, A., & Dimοpoulos, G. (2014) · Molecules · doi:10.3390/molecules19011085 · Cited by 177 · see citing works
Böll, B., Schalk, E., Buchheidt, D., Hasenkamp, J., Kiehl, M. G., Kiderlen, T. R., Kochanek, M., Koldehoff, M., Kostrewa, P., Classen, A. Y., et al. (2020) · Annals of Hematology · doi:10.1007/s00277-020-04286-x · Cited by 176 · see citing works
Colombo, A. L., Guimarães, T., Camargo, L. F. A., Richtmann, R., Queiroz‐Telles, F., Salles, M. J. C., da Cunha, C. A., Shikanai‐Yasuda, M. A., Moretti, M. L., & Nucci, M. (2013) · The Brazilian Journal of Infectious Diseases · doi:10.1016/j.bjid.2013.02.001 · Cited by 157 · see citing works
Self-citationImpact of Therapeutic Strategies on the Prognosis of Candidemia in the ICU*
Puig‐Asensio, M., Pemán, J., Zaragoza, R., Garnacho‐Montero, J., Martín‐Mazuelos, E., Cuenca‐Estrella, M., & Almirante, B. (2014) · Critical Care Medicine · doi:10.1097/ccm.0000000000000221 · Cited by 147 · see citing works
Ruhnke, M., Rickerts, V., Cornely, O. A., Buchheidt, D., Glöckner, A., Heinz, W., Höhl, R., Horré, R., Karthaus, M., Kujath, P., et al. (2011) · Mycoses · doi:10.1111/j.1439-0507.2011.02040.x · Cited by 137 · see citing works
Kayaaslan, B., Eser, F., Kaya Kalem, A., Bilgic, Z., Asilturk, D., Hasanoglu, I., Ayhan, M., Tezer Tekce, Y., Erdem, D., Turan, S., et al. (2021) · Mycoses · doi:10.1111/myc.13332 · Cited by 126 · see citing works
Fernández-Ruiz, M., Aguado, J. M., Almirante, B., Lora-Pablos, D., Padilla, B., Puig-Asensio, M., Montejo, M., García-Rodríguez, J., Pemán, J., Ruiz Pérez de Pipaón, M., et al. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu158 · Cited by 122 · see citing works
Garnacho‐Montero, J., Díaz‐Martín, A., García-Cabrera, E., de Pipaón, M. R. P., Hernandez-Caballero, C., & Lepe, J. A. (2012) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dks347 · Cited by 113 · see citing works
Gamaletsou, M. N., Walsh, T. J., Zaoutis, T., Pagoni, M., Kotsopoulou, M., Voulgarelis, M., Panayiotidis, P., Vassilakopoulos, T., Angelopoulou, M. K., Marangos, M., et al. (2014) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12312 · Cited by 112 · see citing works
Treatment of Invasive Candidiasis: A Narrative Review
Ben-Ami, R. (2018) · Journal of Fungi · doi:10.3390/jof4030097 · Cited by 111 · see citing works
Epidemiology and Outcome of Trichosporon Fungemia: A Review of 185 Reported Cases From 1975 to 2014
Liao, Y., Lu, X., Yang, S., Luo, Y., Chen, Q., & Yang, R. (2015) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofv141 · Cited by 105 · see citing works
Hentrich, M., Schalk, E., Schmidt‐Hieber, M., Chaberny, I. F., Mousset, S., Buchheidt, D., Ruhnke, M., Penack, O., Salwender, H. J., Wolf, H.-H., et al. (2014) · Annals of Oncology · doi:10.1093/annonc/mdt545 · Cited by 105 · see citing works
zakhour, R. G., Chaftari, A., & RAAD, I. I. (2016) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(16)30213-4 · Cited by 97 · see citing works
Strength in numbers: antifungal strategies against fungal biofilms
Ramage, G., Robertson, S. N., & Williams, C. (2013) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2013.10.023 · Cited by 87 · see citing works
Farmakiotis, D., Kyvernitakis, A., Tarrand, J. J., & Kontoyiannis, D. P. (2015) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2014.07.006 · Cited by 86 · see citing works
The prevention, diagnosis and management of central venous line infections in children
Chesshyre, E. L. D., Goff, Z., Bowen, A. C., & Carapetis, J. R. (2015) · Journal of Infection · doi:10.1016/j.jinf.2015.04.029 · Cited by 87 · see citing works
Wang, E., Farmakiotis, D., Yang, D., McCue, D. A., Kantarjian, H. M., Kontoyiannis, D. P., & Mathisen, M. S. (2015) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkv087 · Cited by 82 · see citing works
Invasive fungal infections in patients with cancer in the Intensive Care Unit
Sipsas, N. V., & Kontoyiannis, D. P. (2012) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2011.11.017 · Cited by 80 · see citing works
Nucci, M., & Anaissie, E. J. (2014) · Blood · doi:10.1182/blood-2014-04-516211 · Cited by 79 · see citing works
Self-citationPuig‐Asensio, M., Ruíz-Camps, I., Fernández‐Ruiz, M., Aguado, J. M., Muñóz, P., Valerio, M., Delgado‐Iribarren, A., Merino, P., Bereciartúa, E., Fortün, J., et al. (2015) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2014.12.027 · Cited by 79 · see citing works
Treatment of fungal disease in the setting of neutropenia
Walsh, T. J., & Gamaletsou, M. N. (2013) · Hematology · doi:10.1182/asheducation-2013.1.423 · Cited by 78 · see citing works
Tadec, L., Talarmin, J., Gastinne, T., Bretonnière, C., Miegeville, M., Pape, P. L., & Morio, F. (2016) · Mycoses · doi:10.1111/myc.12470 · Cited by 79 · see citing works
Ruhnke, M., Cornely, O. A., Schmidt‐Hieber, M., Alakel, N., Boell, B., Buchheidt, D., Christopeit, M., Hasenkamp, J., Heinz, W., Hentrich, M., et al. (2020) · Mycoses · doi:10.1111/myc.13082 · Cited by 76 · see citing works
European expert opinion on the management of invasive candidiasis in adults
Kullberg, B. J., Verweij, P. E., Akova, M., Arendrup, M. C., Billé, J., Calandra, T., Cuenca‐Estrella, M., Herbrecht, R., Jacobs, F., Kalin, M., et al. (2011) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2011.03615.x · Cited by 72 · see citing works
Self-citationOccurrence, presentation and treatment of candidemia
Mikulska, M., Del Bono, V., Ratto, S., & Viscoli, C. (2012) · Expert Review of Clinical Immunology · doi:10.1586/eci.12.52 · Cited by 71 · see citing works
Epidemiology and predictors of a poor outcome in elderly patients with candidemia
Guimarães, T., Nucci, M., de Mendonça, J. S., Martínez, R., Brito, L. R., Silva, N., Moretti, M. L., Salomão, R., & Colombo, A. L. (2012) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2012.02.005 · Cited by 67 · see citing works
Self-citationKeighley, C., Cooley, L., Morris, A. J., Ritchie, D., Clark, J. E., Boan, P., & Worth, L. J. (2021) · Internal Medicine Journal · doi:10.1111/imj.15589 · Cited by 65 · see citing works
The Impact of Biofilm Formation on the Persistence of Candidemia
Li, W., Chen, Y., Kuo, S., Chen, F., & Lee, C. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01196 · Cited by 63 · see citing works
The role of antifungals against Candida biofilm in catheter-related candidemia
Bouza, E., Guinea, J., & Guembe, M. (2014) · Antibiotics · doi:10.3390/antibiotics4010001 · Cited by 62 · see citing works
Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting
Lepak, A., & Andes, D. (2011) · Critical Care Clinics · doi:10.1016/j.ccc.2010.11.001 · Cited by 62 · see citing works
Gedık, H., Şimşek, F., Yıldırmak, T., Kantürk, A., Arica, D. A., Aydın, D., Yokuş, O., & Demirel, N. (2014) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s68450 · Cited by 59 · see citing works
Bench-to-bedside review: Therapeutic management of invasive candidiasis in the intensive care unit
Bassetti, M., Mikulska, M., & Viscoli, C. (2010) · Critical Care · doi:10.1186/cc9239 · Cited by 57 · see citing works
The Clinical Importance of Fungal Biofilms
Ramage, G., & Williams, C. (2013) · Advances in applied microbiology · doi:10.1016/b978-0-12-407673-0.00002-3 · Cited by 54 · see citing works
Gaining Insights from Candida Biofilm Heterogeneity: One Size Does Not Fit All
Kean, R., Delaney, C., Rajendran, R., Sherry, L., Metcalfe, R., Thomas, R., McLean, W., Williams, C., & Ramage, G. (2018) · Journal of Fungi · doi:10.3390/jof4010012 · Cited by 53 · see citing works
Mortality and risk factor analysis for Candida blood stream infection: A multicenter study
Kato, H., Yoshimura, Y., Suido, Y., Shimizu, H., Ide, K., Sugiyama, Y., Matsuno, K., & Nakajima, H. (2019) · Journal of Infection and Chemotherapy · doi:10.1016/j.jiac.2019.01.002 · Cited by 55 · see citing works
Diagnosis and Treatment of Candidemia in the Intensive Care Unit
Bassetti, M., Giacobbe, D. R., Vena, A., & Wolff, M. (2019) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0039-1693704 · Cited by 55 · see citing works
Marschall, J. (2010) · Infection and Drug Resistance · doi:10.2147/idr.s10105 · Cited by 54 · see citing works
Invasive Fungal Infections in the ICU
Shoham, S., & Marwaha, S. (2009) · Journal of Intensive Care Medicine · doi:10.1177/0885066609355262 · Cited by 53 · see citing works
Central venous catheter (CVC) removal for patients of all ages with candidaemia
Janum, S., & Afshari, A. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011195.pub2 · Cited by 49 · see citing works
Kato, H., Yoshimura, Y., Suido, Y., Ide, K., Sugiyama, Y., Matsuno, K., & Nakajima, H. (2018) · Infection · doi:10.1007/s15010-018-1163-z · Cited by 51 · see citing works
Mortality-associated factors of candidemia: a multi-center prospective cohort in Turkey
Kutlu, M., Kutlu, S. S., Çavuş, S. A., Öztürk, Ş. B., Tasbakan, M. I., Özhak, B., Kaya, O., Kutsoylu, O. Ö. E., Akar, Ş. Ş., Turhan, Ö., et al. (2022) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-021-04394-0 · Cited by 48 · see citing works
Diagnostic Usefulness of Differential Time to Positivity for Catheter-Related Candidemia
Park, K., Lee, M. S., Lee, S., Choi, S., Sung, H., Kim, M., Kim, Y. S., Woo, J. H., & Kim, S. (2014) · Journal of Clinical Microbiology · doi:10.1128/jcm.00605-14 · Cited by 48 · see citing works
on behalf of the COMIC Study Group (Collaborative Group on Mycosis), Agnelli, C., Valerio, M., Bouza, E., Vena, A., Guinea, J., Martínez‐Jiménez, M. D. C., Marcos-Zambrano, L. J., Escribano, P., & Muñóz, P. (2019) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-019-03477-3 · Cited by 47 · see citing works
Glöckner, A. (2011) · European journal of medical research · doi:10.1186/2047-783x-16-4-167 · Cited by 46 · see citing works
Marcos-Zambrano, L. J., Gómez-Perosanz, M., Escribano, P., Bouza, E., & Guinea, J. (2017) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx010 · Cited by 44 · see citing works
A proposal for a comprehensive approach to infections across the surgical pathway
Sartelli, M., Pagani, L., Iannazzo, S., Moro, M. L., Viale, P., Pan, A., Ansaloni, L., Coccolini, F., D’Errico, M. M., Agreiter, I., et al. (2020) · World Journal of Emergency Surgery · doi:10.1186/s13017-020-00295-3 · Cited by 49 · see citing works
Chen, C., Huang, S., Tsay, W., Yao, M., Tang, J., Ko, B.-S., Chou, W., Tien, H., & Hsueh, P. (2012) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2012.07.022 · Cited by 43 · see citing works
Analyzing candidemia guideline adherence identifies opportunities for antifungal stewardship
Mellinghoff, S. C., Hartmann, P., Cornely, F. B., Knauth, L., Koehler, F. C., Köhler, P., Krause, C., Kronenberg, C., Kranz, S.-L., Menon, V. P., et al. (2018) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-018-3285-8 · Cited by 43 · see citing works
Candidemia: An Update on Epidemiology, Risk Factors, Diagnosis, Susceptibility, and Treatment
Cabrera-Guerrero, J. P., García-Salazar, E., Hernández‐Silva, G., Herrera, A. C., Martínez-Herrera, E. O., Pinto‐Almazán, R., León, M. G. F.-D., & Castro-Fuentes, C. A. (2025) · Pathogens · doi:10.3390/pathogens14080806 · Cited by 41 · see citing works
for the COMIC Study Group, Vena, A., Bouza, E., Corisco, R., Machado, M., Valerio, M., Sánchez, C., & Muñoz, P. (2020) · Infectious Diseases and Therapy · doi:10.1007/s40121-020-00281-x · Cited by 41 · see citing works
Recommendations for the management of candidemia in adults in Latin America
Nucci, M., Thompson-Moya, L., Guzmán-Blanco, M., Tiraboschi, I. N., Cortés, J. A., Echevarria, J. I., Sifuentes‐Osornio, J., Zurita, J., Santolaya, M. E., Matute, T. A., et al. (2013) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2013.05.007 · Cited by 41 · see citing works
Self-citationScott, L. J. (2012) · Drugs · doi:10.2165/11209970-000000000-00000 · Cited by 39 · see citing works
Persistent Candidemia: Causes and Investigations
Nucci, M. (2010) · Current Fungal Infection Reports · doi:10.1007/s12281-010-0039-1 · Cited by 36 · see citing works
Self-citationAlothman, A. F., Al-Musawi, T., Al-Abdely, H. M., Salman, J. A., AlMaslamani, M. A. R. S., Yared, N., Butt, A. A., Raghubir, N., Morsi, W. E., & Althaqafi, A. O. (2013) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2013.08.002 · Cited by 35 · see citing works
Chalmers, C., Gaur, S., Chew, J. L. L., Wright, T., Kumar, A., Mathur, S., Wan, W., Gould, I. M., Leanord, A., & Bal, A. M. (2011) · Mycoses · doi:10.1111/j.1439-0507.2011.02027.x · Cited by 36 · see citing works
Risks for infection in patients with myelodysplasia and acute leukemia
Pagano, L., & Caira, M. (2012) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e328358b000 · Cited by 34 · see citing works
Recommendations for the management of candidemia in children in Latin America
Santolaya, M. E., Telles, F. D. Q., Matute, T. A., Colombo, A. L., Zurita, J., Tiraboschi, I. N., Cortés, J. A., Thompson-Moya, L., Guzmán-Blanco, M., Sifuentes‐Osornio, J., et al. (2013) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2013.05.010 · Cited by 34 · see citing works
Self-citationFungal Infections in Cancer Patients
Angarone, M. (2014) · Cancer treatment and research · doi:10.1007/978-3-319-04220-6_4 · Cited by 31 · see citing works
Chen, X.-C., Xu, J., & Wu, D.-P. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1523 · Cited by 32 · see citing works
Time of catheter removal in candidemia and mortality
Nucci, M., Braga, P. R., Nouér, S. A., & Anaissie, E. J. (2018) · The Brazilian Journal of Infectious Diseases · doi:10.1016/j.bjid.2018.10.278 · Cited by 32 · see citing works
Self-citationINVASIVE CANDIDIASIS IN NON-HEMATOLOGICAL PATIENTS.
Mikulska, M., Bassetti, M., Ratto, S., & Viscoli, C. (2011) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2011.007 · Cited by 32 · see citing works
Kimura, M., Asano‐Mori, Y., Sakoh, T., Abe, M., Ueno, K., Hoshino, Y., Nakamura, S., Umeyama, T., Yamagoe, S., Miyazaki, Y., et al. (2022) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02081-21 · Cited by 30 · see citing works
The End of an Era in Defining the Optimal Treatment of Invasive Candidiasis
Clancy, C. J., & Nguyen, M. H. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis023 · Cited by 31 · see citing works
Rodríguez‐Créixems, M., Muñóz, P., Martín‐Rabadán, P., Cercenado, E., Guembe, M., & Bouza, E. (2012) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12050 · Cited by 30 · see citing works
Marcos-Zambrano, L. J., Gómez-Perosanz, M., Escribano, P., Zaragoza, O., Bouza, E., & Guinea, J. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.03065-15 · Cited by 28 · see citing works
Epidemiology and prognosis of candidaemia in elderly patients
Ramos, A., López, N. V., Sánchez‐Romero, I., Padilla, B., Amador, P. M., Garnacho‐Montero, J., Ruíz-Camps, I., Montejo, M., Salavert, M., Mensa, J., et al. (2017) · Mycoses · doi:10.1111/myc.12677 · Cited by 28 · see citing works
Ala‐Houhala, M., & Anttila, V. (2020) · Mycoses · doi:10.1111/myc.13085 · Cited by 28 · see citing works
Micafungin: an evidence-based review of its place in therapy
Reboli, A. C., & de la Torre (2014) · Core evidence · doi:10.2147/ce.s36304 · Cited by 28 · see citing works
Tseng, T.-Y., Chen, T., Ho, C., Lin, P., Chou, C.-H., Tsai, C.-T., Wang, J.-H., Chi, C.-Y., & Ho, M. (2017) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2016.08.015 · Cited by 27 · see citing works
Hu, B., Du, Z., Kang, Y., Zang, B., Cui, W., Qin, B., Fang, Q., Qiu, H., & Li, J. (2014) · BMC Infectious Diseases · doi:10.1186/s12879-014-0594-0 · Cited by 26 · see citing works
Tsai, M.-H., Hsu, J., Chu, S., Chang, P., Lai, M., Wu, I.-H., Huang, H., Chiang, M., Fu, R.-H., & Lu, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-01123-6 · Cited by 26 · see citing works
Clinical impact of Candida spp. biofilm production in a cohort of patients with candidemia
Monfredini, P. M., Souza, A. C. R., Cavalheiro, R. P., Siqueira, R. A., & Colombo, A. L. (2017) · Medical Mycology · doi:10.1093/mmy/myx133 · Cited by 25 · see citing works
Fungal Biofilms in Human Disease
Williams, C., & Ramage, G. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-09782-4_2 · Cited by 25 · see citing works
Increasing morbidity and mortality of candidemia over one decade in a Swiss university hospital
Battistolo, J., Glampedakis, E., Damonti, L., Poissy, J., Grandbastien, B., Kalbermatter, L., Pagani, J., Eggimann, P., Bochud, P., Calandra, T., et al. (2021) · Mycoses · doi:10.1111/myc.13376 · Cited by 23 · see citing works
Candidaemia in a paediatric centre and importance of central venous catheter removal
Öncel, E. K., Kara, A., Özsürekçi, Y., Arıkan-Akdağlı, S., Cengiz, A. B., Ceyhan, M., Gür, D., Çelik, M., & Parlakay, A. Ö. (2015) · Mycoses · doi:10.1111/myc.12288 · Cited by 24 · see citing works
Infection control measures to prevent hospital transmission of candida
Türe, Z., & Alp, E. (2018) · Hospital Practice · doi:10.1080/21548331.2018.1510282 · Cited by 24 · see citing works
Initial antifungal strategy does not correlate with mortality in patients with candidemia
Murri, R., Scoppettuolo, G., Ventura, G., Fabbiani, M., Giovannenze, F., Taccari, F., Milozzi, E., Posteraro, B., Sanguinetti, M., Cauda, R., et al. (2015) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-015-2527-2 · Cited by 23 · see citing works
Infections in Patients with Acute Leukemia
Rolston, K. V. I. (2014) · Springer eBooks · doi:10.1007/978-3-662-44000-1_1 · Cited by 23 · see citing works
Jiang, Z.-Q., Wang, S., Feng, D.-D., Bing-xin, Z., Mao, S., & Wu, J. (2019) · Journal of Critical Care · doi:10.1016/j.jcrc.2019.04.019 · Cited by 22 · see citing works
Savio, R. D., Jagathkar, G. M., Pandit, R. A., Mishra, R. C., Clerk, A. M., Zirpe, K. G., Sahoo, T. K., Jakkinaboina, S., & Jampala, N. (2019) · Indian Journal of Critical Care Medicine · doi:10.5005/jp-journals-10071-g23183 · Cited by 22 · see citing works
- Authors
- Nucci, M., Anaissie, E., Betts, R. F., Dupont, B. F., Wu, C., Buell, D. N., Kovanda, L., & Lortholary, O.
- Affiliations
- University of Arkansas for Medical Sciences (US)
- University of Rochester (US)
- Hôpital Necker-Enfants Malades (FR)
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-08
- Volume
- 51
- Issue
- 3
- Pages
- 295-303
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2041099687
- Cited by
- 228
- References
- 31
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 7 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 10 · 2019: 12 · 2018: 14 · 2017: 11 · 2016: 15 · 2015: 17 · 2014: 29 · 2013: 23 · 2012: 32
- FWCI
- 16.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Health Professions › Emergency Medical Services › Central Venous Catheters and Hemodialysis
- Health Sciences › Medicine › Epidemiology › Infective Endocarditis Diagnosis and Management
- Keywords
- candidemia, central venous catheter removal, early catheter removal, persistent candidemia, treatment success, survival, neutropenia, APACHE II score, antifungal therapy
- MeSH terms
- Adult, Aged, Aged, 80 and over, Antifungal Agents, Blood, Candidiasis, Double-Blind Method, Female, Humans, Male, Middle Aged, Prospective Studies, Time Factors, Survival Analysis, Fungemia, Treatment Outcome, Catheter-Related Infections
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
