The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Carotid Artery Intimal-Medial Thickness and Left Ventricular Hypertrophy in Children With Elevated Blood Pressure
Abstract
Objectives. To determine the association between carotid artery intimal-medial thickness (cIMT) and left ventricular mass index (LVMI) in children with elevated blood pressure. Methods. Study subjects (n = 32; mean age: 13.9 ± 2.7 years) were untreated new referrals to a pediatric hypertension clinic with confirmed elevated blood pressure. LVM was calculated from 2-dimensionally guided m-mode echocardiographic measurements of the left ventricle. LVMI was calculated as LVM (g)/height (m)2.7, and left ventricular hypertrophy (LVH) was defined as LVMI >95th percentile. Carotid artery duplex ultrasound was performed by protocol by experienced vascular sonographers who were unaware of the echocardiography results. The thickest IMT complex of the far wall of the distal common carotid artery was measured in longitudinal B-mode section using a high-resolution linear array of 8 MHz. Results. The prevalence of LVH and increased cIMT was 41% and 28%, respectively. Subjects with increased cIMT had higher LVMI (46.8 g/m2.7 vs 31.4 g/m2.7) than those with normal cIMT. The LVH prevalence was 89% (8 of 9) among subjects with increased cIMT as compared with 22% (5 of 23) in subjects with normal cIMT. cIMT was positively correlated with body mass index (r = 0.43), interventricular septal thickness (r = 0.58), posterior wall thickness (r = 0.54), and LVMI (r = 0.54). cIMT and LVMI were positively associated after accounting for age, gender, and body mass index. Conclusions. These findings raise the possibility that carotid duplex ultrasound, by indicating the presence of early arterial wall changes, may be useful for predicting other cardiovascular sequelae in hypertensive children.
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Cites
Echocardiographic assessment of left ventricular hypertrophy: Comparison to necropsy findings
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Cited by
Lurbe, E., Agabiti-Rosei, E., Cruickshank, J. K., Dominiczak, A., Erdine, S., Hirth, A., Invitti, C., Litwin, M., Mancia, G., Pall, D., et al. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000001039 · Cited by 1,379
Urbina, E. M., Williams, R. V., Alpert, B. S., Collins, R. T., Daniels, S. R., Hayman, L., Jacobson, M., Mahoney, L., Mietus-Snyder, M., Rocchini, A., et al. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.192639 · Cited by 641
Urbina, E., Alpert, B., Flynn, J., Hayman, L., Harshfield, G. A., Jacobson, M., Mahoney, L., McCrindle, B., Mietus-Snyder, M., Steinberger, J., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.190329 · Cited by 560
Lande, M. B., Kaczorowski, J. M., Auinger, P., Schwartz, G. J., & Weitzman, M. (2003) · The Journal of Pediatrics · doi:10.1067/s0022-3476(03)00412-8 · Cited by 197
Srinivasan, S. R., Myers, L., & Berenson, G. S. (2006) · Hypertension · doi:10.1161/01.hyp.0000226410.11198.f4 · Cited by 143
Metadata
- Authors
- Sorof, J. M., Alexandrov, A. V., Cardwell, G., & Portman, R. J.
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2003-01-01
- Volume
- 111
- Issue
- 1
- Pages
- 61-66
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W2004248853
- Cited by
- 388
- References
- 47
- FWCI
- 11.73
- Type
- journal article
- Language
- en
- Open access
- closed
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