CoChat
Sign Up
Cited by 322Food Allergy and Anaphylaxis ResearchPharmacovigilance and Adverse Drug ReactionsDrug-Induced Adverse Reactions

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Risk of anaphylaxis after vaccination of children and adolescents.

Bohlke, Kari, Davis, Robert L., Marcy, S. M., Braun, M. M., DeStefano, Frank, Black, Steven B., Mullooly, John P., Thompson, Robert S., for the Vaccine Safety Datalink Team·2003·PEDIATRICS
DOI 10.1542/peds.112.4.815
Open this paper in CoChat — free account

Abstract

OBJECTIVE: To quantify the risk of anaphylaxis after vaccination of children and adolescents. METHODS: The study population consisted of children and adolescents who were enrolled at 4 health maintenance organizations that participated in the Vaccine Safety Datalink Project. For the period 1991-1997, we identified potential cases by searching for occurrences of International Classification of Diseases, Ninth Revision (ICD-9) code 995.0 (anaphylactic shock), E948.0 through E948.9 (adverse reaction from bacterial vaccines), and E949.0 through E949.9 (adverse reaction from other vaccines and biological substances). At 1 study site, we also included a range of other allergy codes. We restricted to diagnoses on days 0 to 2 after vaccination (ICD-9 995.0) or day 0 (all other ICD-9 codes). We then reviewed the medical record to confirm the diagnosis. RESULTS: We identified 5 cases of potentially vaccine-associated anaphylaxis after administration of 7 644 049 vaccine doses, for a risk of 0.65 cases/million doses (95% confidence interval: 0.21-1.53). None of the episodes resulted in death. Vaccines that were administered before the anaphylactic episodes were generally given in combination and included measles-mumps-rubella, hepatitis B, diphtheria-tetanus, diphtheria-tetanus-pertussis, Haemophilus influenzae type b, and oral polio vaccine. One case of anaphylaxis followed measles-mumps-rubella vaccine alone. At the site at which we reviewed additional allergy codes, we identified 1 case after 653 990 vaccine doses, for a risk of 1.53 cases/million doses (95% confidence interval: 0.04-8.52). CONCLUSIONS: Patients and health care providers can be reassured that vaccine-associated anaphylaxis is a rare event. Nevertheless, providers should be prepared to provide immediate medical treatment should it occur.

Overview

Integrity signals

Registry

Crossref · 10.1542/peds.112.4.815

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Cited by

Sorted by citations

See all 322

Related

See all

Metadata

Authors
Bohlke, K., Davis, R. L., Marcy, S. M., Braun, M. M., DeStefano, F., Black, S. B., Mullooly, J. P., Thompson, R. S., & for the Vaccine Safety Datalink Team
Affiliations
  • Group Health Cooperative (US)
  • Kaiser Foundation Hospital (US)
  • Center for Biologics Evaluation and Research (US)
  • Centers for Disease Control and Prevention (US)
  • Kaiser Permanente (US)
ORCID
Venue
PEDIATRICS
Publisher
American Academy of Pediatrics (AAP)
Published
2003-10-01
Volume
112
Issue
4
Pages
815-820
ISSN
  • 0031-4005 (ISSN-L)
  • 1098-4275
DOI
10.1542/peds.112.4.815
OpenAlex
W2111371073
Cited by
320
References
24
Citations by year
2026: 2 · 2025: 7 · 2024: 9 · 2023: 8 · 2022: 11 · 2021: 14 · 2020: 5 · 2019: 14 · 2018: 16 · 2017: 11 · 2016: 16 · 2015: 17 · 2014: 16 · 2013: 14 · 2012: 25
FWCI
6.71
Type
journal article
Language
en
Open access
closed
Locations
  • PEDIATRICS (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Kaiser Permanente
  • Centers for Disease Control and Prevention
Topics
  • Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
  • Health Sciences › Medicine › Pharmacology (medical) › Drug-Induced Adverse Reactions
Keywords
vaccine anaphylaxis, vaccine safety, children and adolescents, MMR vaccine, hepatitis B vaccine, diphtheria-tetanus vaccine, Haemophilus influenzae type b vaccine, oral polio vaccine, vaccine adverse events, anaphylactic shock
MeSH terms
Adolescent, Anaphylaxis, California, Child, Child, Preschool, Female, Health Maintenance Organizations, Humans, Infant, Infant, Newborn, Male, Oregon, Risk, Vaccination, Vaccines, Washington, Cohort Studies, Adverse Drug Reaction Reporting Systems

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review