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Cited by 125Thyroid Disorders and TreatmentsOphthalmology and Eye DisordersThyroid and Parathyroid Surgery

The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.

Predicting the Likelihood of Remission in Children With Graves’ Disease: A Prospective, Multicenter Study

Glaser, Nicole S., Styne, Dennis M., for the Organization of Pediatric Endocrinologists of Northern California Collaborative Graves’ Disease Study Group·2008·Pediatrics
DOI 10.1542/peds.2007-1535
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Abstract

OBJECTIVE. The optimal treatment for Graves’ disease in children is controversial. Antithyroid medications are often used initially, but many children eventually require alternative therapies. We evaluated predictors of remission after 2 years of antithyroid medication use. METHODS. We prospectively studied children who had Graves’ disease and were treated with antithyroid medications. We compared children who achieved remission after 2 years with those who had persistent disease to determine which variables were associated with remission; multiple logistic regression and binary recursive partitioning analyses were used to evaluate interactions among predictive variables. RESULTS. Of 51 children who completed the study, 15 (29%) achieved remission. Children who achieved remission had lower thyroid hormone concentrations at presentation than those with persistent disease (free thyroxine: 6.17 ± 3.10 vs 9.86 ± 7.54 ng/dL; total triiodothyronine: 431 ± 175 vs 561 ± 225 ng/dL). Children who achieved remission were also more likely to be euthyroid within 3 months of initiating propylthiouracil (82% vs 29%). Binary recursive partitioning analysis identified rapid achievement of euthyroid status after initiation of propylthiouracil, lower initial triiodothyronine, and older age as significant predictors of remission. CONCLUSIONS. Thyroid hormone concentrations at diagnosis, age, and initial response to propylthiouracil can be used to stratify patients according to the likelihood of remission after 2 years of antithyroid medication use. These data provide a useful guide for clinical decision-making regarding Graves’ disease in children.

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Research works printed but not linked: 2

  1. Baker B, Shapiro B, Fig L, Woodbury D, Sisson J, Beierwaltes W. Unusual complications of antithyroid drug therapy: four case reports and review of literature. Thyroidology.1989;1(1):17–26
  2. Marcocci C, Marion M. Thyroid directed antibodies. In: Braverman L, Utiger R, eds. The Thyroid. Philadelphia, PA: Lippincott Williams & Wilkins;2005:360–372

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Metadata

Authors
Glaser, N. S., Styne, D. M., & for the Organization of Pediatric Endocrinologists of Northern California Collaborative Graves’ Disease Study Group
Affiliations
University of California, Davis (US)
ORCID
Venue
Pediatrics
Publisher
American Academy of Pediatrics (AAP)
Published
2008-03-01
Volume
121
Issue
3
Pages
e481-e488
ISSN
  • 0031-4005 (ISSN-L)
  • 1098-4275
DOI
10.1542/peds.2007-1535
OpenAlex
W2080637533
Cited by
125
References
32
Citations by year
2026: 4 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 8 · 2020: 10 · 2019: 12 · 2018: 10 · 2017: 6 · 2016: 7 · 2015: 8 · 2014: 10 · 2013: 8 · 2012: 9
FWCI
5.52
Type
journal article
Language
en
Open access
closed
Locations
  • PEDIATRICS (publishedVersion)
  • PubMed (publishedVersion)
Funders
Quest Diagnostics
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Ophthalmology › Ophthalmology and Eye Disorders
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Keywords
Graves' disease, pediatric Graves' disease, remission prediction, antithyroid drugs, propylthiouracil, thyroid hormone levels, free thyroxine, triiodothyronine, euthyroid status, prognostic factors, age
MeSH terms
Adolescent, Age Factors, Child, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Follow-Up Studies, Graves Disease, Humans, Male, Predictive Value of Tests, Propylthiouracil, Prospective Studies, Severity of Illness Index, Sex Factors, Antithyroid Agents, Thyroid Function Tests, Multivariate Analysis, Logistic Models, Treatment Outcome, Risk Assessment

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