The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Safety and Efficacy of a Fish-Oil–Based Fat Emulsion in the Treatment of Parenteral Nutrition–Associated Liver Disease
Abstract
BACKGROUND. Parenteral nutrition–associated liver disease can be a progressive and fatal entity in children with short-bowel syndrome. Soybean-fat emulsions provided as part of standard parenteral nutrition may contribute to its pathophysiology. METHODS. We compared safety and efficacy outcomes of a fish-oil–based fat emulsion in 18 infants with short-bowel syndrome who developed cholestasis (serum direct bilirubin level of >2 mg/dL) while receiving soybean emulsions with those from a historical cohort of 21 infants with short-bowel syndrome who also developed cholestasis while receiving soybean emulsions. The primary end point was time to reversal of cholestasis (3 consecutive measurements of serum direct bilirubin level of ≤2 mg/dL). RESULTS. Among survivors, the median time to reversal of cholestasis was 9.4 and 44.1 weeks in the fish-oil and historical cohorts, respectively. Subjects who received fish-oil–based emulsion experienced reversal of cholestasis 4.8 times faster than those who received soybean emulsions and 6.8 times faster in analysis adjusted for baseline bilirubin concentration, gestational age, and the diagnosis of necrotizing enterocolitis. A total of 2 deaths and 0 liver transplantations were recorded in the fish-oil cohort and 7 deaths and 2 transplantations in the historical cohort. The provision of fish-oil–based fat emulsion was not associated with essential fatty acid deficiency, hypertriglyceridemia, coagulopathy, infections, or growth delay. CONCLUSIONS. Parenteral fish-oil–based fat emulsions are safe and may be effective in the treatment of parenteral nutrition–associated liver disease.
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Steatohepatitis: A tale of two “hits”?
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Self-citationImmune modulation by parenteral lipid emulsions
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Cited by
ESPEN guideline on clinical nutrition in liver disease
Plauth, M., Bernal, W., Dasarathy, S., Merli, M., Plank, L. D., Schütz, T., & Bischoff, S. C. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.12.022 · Cited by 674
Chen, B., Zhou, Y., Yang, P., Wan, H., & Wu, X. (2010) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607110362532 · Cited by 112
Dai, Y.-J., Sun, L.-L., Li, M.-Y., Ding, C.-L., Su, Y.-C., Sun, L.-J., Xue, S.-H., Yan, F., Zhao, C.-H., & Wang, W. (2016) · Advances in Nutrition · doi:10.3945/an.114.007427 · Cited by 61
Carlson, S. J., O’Loughlin, A. A., Anez-Bustillos, L., Baker, M. A., Andrews, N. A., Gunner, G., Dao, D. T., Pan, A., Nandivada, P., Chang, M., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00072 · Cited by 24
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Metadata
- Authors
- Gura, K. M., Lee, S., Valim, C., Zhou, J., Kim, S., Modi, B. P., Arsenault, D. A., Strijbosch, R. A. M., Lopes, S., Duggan, C., & Puder, M.
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2008-03-01
- Volume
- 121
- Issue
- 3
- Pages
- e678-e686
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W2066163388
- Cited by
- 455
- References
- 19
- FWCI
- 33.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gura, K. M., Lee, S., Valim, C., Zhou, J., Kim, S., Modi, B. P., Arsenault, D. A., Strijbosch, R. A. M., Lopes, S., Duggan, C., & Puder, M. (2008). Safety and Efficacy of a Fish-Oil–Based Fat Emulsion in the Treatment of Parenteral Nutrition–Associated Liver Disease. Pediatrics. https://doi.org/10.1542/peds.2007-2248
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