Cited by 457Pesticide Exposure and ToxicityAttention Deficit Hyperactivity DisorderEffects and risks of endocrine disrupting chemicals

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Attention-Deficit/Hyperactivity Disorder and Urinary Metabolites of Organophosphate Pesticides

Open access

Bouchard, Maryse F., Bellinger, David C., Wright, Robert O., Weisskopf, Marc G.·2010·Pediatrics

DOI 10.1542/peds.2009-3058PMC PMC3706632

Open this paper in CoChat — free account

Abstract

OBJECTIVE: The goal was to examine the association between urinary concentrations of dialkyl phosphate metabolites of organophosphates and attention-deficit/hyperactivity disorder (ADHD) in children 8 to 15 years of age. METHODS: Cross-sectional data from the National Health and Nutrition Examination Survey (2000–2004) were available for 1139 children, who were representative of the general US population. A structured interview with a parent was used to ascertain ADHD diagnostic status, on the basis of slightly modified criteria from the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. RESULTS: One hundred nineteen children met the diagnostic criteria for ADHD. Children with higher urinary dialkyl phosphate concentrations, especially dimethyl alkylphosphate (DMAP) concentrations, were more likely to be diagnosed as having ADHD. A 10-fold increase in DMAP concentration was associated with an odds ratio of 1.55 (95% confidence interval: 1.14–2.10), with adjustment for gender, age, race/ethnicity, poverty/income ratio, fasting duration, and urinary creatinine concentration. For the most-commonly detected DMAP metabolite, dimethyl thiophosphate, children with levels higher than the median of detectable concentrations had twice the odds of ADHD (adjusted odds ratio: 1.93 [95% confidence interval: 1.23–3.02]), compared with children with undetectable levels. CONCLUSIONS: These findings support the hypothesis that organophosphate exposure, at levels common among US children, may contribute to ADHD prevalence. Prospective studies are needed to establish whether this association is causal.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1542/peds.2009-3058

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED: An acetylcholinesterase-independent mechanism for neurobehavioral impairments after chronic low level exposure to dichlorvos in rats
Verma, S. K., Kumar, V. J., & Gill, K. D. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.11.010 · Cited by 15
Retracted
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): Description, Differences From Previous Versions, and Reliability of Some Common Diagnoses
SHAFFER, D., FISHER, P., LUCAS, C. P., DULCAN, M. K., & SCHWAB-STONE, M. E. (2000) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200001000-00014 · Cited by 3,505
Estimation of Average Concentration in the Presence of Nondetectable Values
Hornung, R. W., & Reed, L. D. (1990) · Applied Occupational and Environmental Hygiene · doi:10.1080/1047322x.1990.10389587 · Cited by 3,495
Urinary Creatinine Concentrations in the U.S. Population: Implications for Urinary Biologic Monitoring Measurements
Barr, D. B., Wilder, L. C., Caudill, S. P., Gonzalez, A. J., Needham, L. L., & Pirkle, J. L. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.7337 · Cited by 1,952
Neurodevelopmental and Functional Outcomes of Extremely Low Birth Weight Infants in the National Institute of Child Health and Human Development Neonatal Research Network, 1993–1994
Vohr, B. R., Wright, L. L., Dusick, A. M., Mele, L., Verter, J. I., Steichen, J. J., Simon, N. P., Wilson-Costello, D., Broyles, S., Bauer, C. R., et al. (2000) · PEDIATRICS · doi:10.1542/peds.105.6.1216 · Cited by 1,143
DSM-IV field trials for attention deficit hyperactivity disorder in children and adolescents
(1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.11.1673 · Cited by 935
Pesticides in the Diets of Infants and Children
National Research Council (1993) · National Academies Press eBooks · doi:10.17226/2126 · Cited by 863
Impact of Prenatal Chlorpyrifos Exposure on Neurodevelopment in the First 3 Years of Life Among Inner-City Children
Rauh, V. A., Garfinkel, R., Perera, F. P., Andrews, H. F., Hoepner, L., Barr, D. B., Whitehead, R., Tang, D., & Whyatt, R. W. (2006) · Pediatrics · doi:10.1542/peds.2006-0338 · Cited by 734

Show all 34 references

Research works printed but not linked: 3

US Department of Agriculture, Agricultural Marketing Service, 2009, Pesticide Data Program: Annual Summary, Calendar Year 2008
Shaffer, 2007, Scoring Manual: Diagnostic Interview Schedule for Children (DISC-IV)
Barr, 2004, Concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the U.S. population, Environ Health Perspect, 112, 186, 10.1289/ehp.6503 · DOI

Sorted by citations

Items 101–200 of 457

Organophosphates and Carbamates
Gupta, R. C., Mukherjee, I. R. M., Doss, R. B., Malik, J. K., & Milatović, D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804239-7.00035-4 · Cited by 65
Neurotoxicity of pesticides in the context of CNS chronic diseases
Arab, A., & Mostafalou, S. (2021) · International Journal of Environmental Health Research · doi:10.1080/09603123.2021.1987396 · Cited by 62
Organophosphate pesticide metabolite concentrations in urine during pregnancy and offspring attention-deficit hyperactivity disorder and autistic traits
van den Dries, M. A., Guxens, M., Pronk, A., Spaan, S., Marroun, H. E., Jusko, T. A., Longnecker, M. P., Ferguson, K. K., & Tiemeier, H. W. (2019) · Environment International · doi:10.1016/j.envint.2019.105002 · Cited by 65
Acetylcholinesterase Activity and Neurodevelopment in Boys and Girls
Suarez-Lopez, J. R., Himes, J. H., Jacobs, D. R., Alexander, B. H., & Gunnar, M. R. (2013) · PEDIATRICS · doi:10.1542/peds.2013-0108 · Cited by 65
Role of endocrine disrupting chemicals in children's neurodevelopment
Ramírez, V., Gálvez-Ontiveros, Y., González-Domenech, P., Baca, M. Á., Rodrigo, L. S., & Rivas, A. (2021) · Environmental Research · doi:10.1016/j.envres.2021.111890 · Cited by 62
Attention-Deficit/Hyperactivity Phenotype in Mice Lacking the Cyclin-Dependent Kinase 5 Cofactor p35
Drerup, J. M., Hayashi, K., Cui, H., Mettlach, G., Long, M. A., Marvin, M. A., Sun, X., Goldberg, M. S., Lutter, M. L., & Bibb, J. A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.016 · Cited by 58
Multiresidue determination and potential risks of emerging pesticides in aquatic products from Northeast China by LC–MS/MS
Fu, L., Lu, X., Tan, J., Wang, L., & Chen, J. (2017) · Journal of Environmental Sciences · doi:10.1016/j.jes.2017.09.010 · Cited by 58
A Comprehensive Analysis of Organic Food: Evaluating Nutritional Value and Impact on Human Health
Rahman, M. A., Baharlouei, P., Koh, E. H. Y., Pirvu, D. G., Rehmani, R., Arcos, M., & Puri, S. (2024) · Foods · doi:10.3390/foods13020208 · Cited by 71
Organophosphorous pesticide breakdown products in house dust and children's urine
Quirós-Alcalá, L., Bradman, A., Smith, K. D., Weerasekera, G., Odetokun, M., Barr, D. B., NISHIOKA, M. G., Castorina, R., Hubbard, A., Nicas, M., et al. (2012) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/jes.2012.46 · Cited by 56
Non-mental diseases associated with ADHD across the lifespan: Fidgety Philipp and Pippi Longstocking at risk of multimorbidity?
Kittel‐Schneider, S., Arteaga-Henríquez, G., Vásquez, A. A., Asherson, P. J., Banaschewski, T., Brikell, I., Buitelaar, J. K., Cormand, B., Faraone, S. V., Freitag, C. M., et al. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.035 · Cited by 59
Exposure to neurotoxicants and the development of attention deficit hyperactivity disorder and its related behaviors in childhood
Yolton, K. A., Cornelius, M. D., Ornoy, A., McGough, J. J., Makris, S. L., & Schantz, S. L. (2014) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2014.05.003 · Cited by 60
The interactions among organophosphate pesticide exposure, oxidative stress and genetic polymorphisms of dopamine receptor D4 increase the risk of attention deficit/hyperactivity disorder in children
Chang, C.-H., Yu, C.-J., Du, J.-C., Chiou, H.-C., Chen, H.-C., Yang, W., Chung, M.-Y., Chen, Y.-S., Hwang, B., Mao, I.-F., et al. (2018) · Environmental Research · doi:10.1016/j.envres.2017.10.011 · Cited by 54
Microbial Detoxification of Residual Pesticides in Fermented Foods: Current Status and Prospects
Armenova, N., Tsigoriyna, L., Arsov, A., Petrov, K. K., & Petrova, P. M. (2023) · Foods · doi:10.3390/foods12061163 · Cited by 58
Prenatal exposure to organophosphorus pesticides and childhood neurodevelopmental phenotypes
Furlong, M., Herring, A. H., Buckley, J. P., Goldman, B. D., Daniels, J. L., Engel, L. S., Wolff, M. S., Chen, J., Wetmur, J., Barr, D. B., et al. (2017) · Environmental Research · doi:10.1016/j.envres.2017.07.023 · Cited by 56
Pesticide Exposure and Stunting among Children in Agricultural Areas
Kartini, A., Subagio, H. W., Hadisaputro, S., Kartasurya, M. I., Suhartono, S., & Budiyono, B. (2019) · The International Journal of Occupational and Environmental Medicine · doi:10.15171/ijoem.2019.1428 · Cited by 52
Attention-deficit/hyperactivity disorder (ADHD)
Dalsgaard, S. (2012) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-012-0360-z · Cited by 51
Dual fluorescence and electrochemical detection of the organophosphorus pesticides—Ethion, malathion and fenthion
Guo, W., Engelman, B. J., Haywood, T. L., Blok, N. B., Beaudoin, D. S., & Obare, S. O. (2011) · Talanta · doi:10.1016/j.talanta.2011.10.015 · Cited by 51
Occupational pesticide exposure and symptoms of attention deficit hyperactivity disorder in adolescent pesticide applicators in Egypt
Rohlman, D. S., Ismail, A. A., Bonner, M. R., Rasoul, G. A., Hendy, O. M., Dickey, L. O., Wang, K., & Olson, J. R. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.05.002 · Cited by 52
Gestational Exposure to Organophosphate Pesticides and Longitudinally Assessed Behaviors Related to Attention-Deficit/Hyperactivity Disorder and Executive Function
Sagiv, S. K., Kogut, K. R., Harley, K. G., Bradman, A., Morga, N., & Eskenazi, B. (2021) · American Journal of Epidemiology · doi:10.1093/aje/kwab173 · Cited by 53
More Signs of Neurotoxicity of Surfactants and Flame Retardants - Neonatal PFOS and PBDE 99 Cause Transcriptional Alterations in Cholinergic Genes in the Mouse CNS
Hallgren, S., Fredriksson, A., & Viberg, H. (2015) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2015.06.014 · Cited by 48
The susceptibility of humans to neurodegenerative and neurodevelopmental toxicities caused by organophosphorus pesticides
Mostafalou, S., & Abdollahi, M. R. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03604-2 · Cited by 50
Distribution and determinants of urinary biomarkers of exposure to organophosphate insecticides in Puerto Rican pregnant women
Lewis, R. C., Cantonwine, D. E., Toro, L. V. A. D., Calafat, A. M., Valentín-Blasini, L., Davis, M., Montesano, M. A., Alshawabkeh, A. N., Cordero, J. F., & Meeker, J. D. (2015) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2015.01.059 · Cited by 48
A review of epidemiologic studies of low-level exposures to organophosphorus insecticides in non-occupational populations
Reiss, R., Chang, E. T., Richardson, R. J., & Goodman, M. G. (2015) · Critical Reviews in Toxicology · doi:10.3109/10408444.2015.1043976 · Cited by 48
Cohort profile: Beyond birth cohort study – The Korean CHildren's ENvironmental health Study (Ko-CHENS)
Jeong, K. S., Kim, S., Kim, W. J., Kim, H., Bae, J., Hong, Y., Ha, M., Ahn, K., Lee, J., Kim, Y., et al. (2018) · Environmental Research · doi:10.1016/j.envres.2018.12.009 · Cited by 46
Dialkyl phosphates in amniotic fluid as a biomarker of fetal exposure to organophosphates in Crete, Greece; association with fetal growth
Koutroulakis, D., Sifakis, S., Tzatzarakis, M. N., Alegakis, A. K., Theodoropoulou, E., Kavvalakis, M. P., Kappou, D., & Tsatsakis, A. M. (2014) · Reproductive Toxicology · doi:10.1016/j.reprotox.2014.03.010 · Cited by 50
Exposure to organophosphorus pesticides in Norwegian mothers and their children: Diurnal variability in concentrations of their biomarkers and associations with food consumption
Cequier, E., Sakhi, A. K., Haug, L. S., & Thomsen, C. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.03.017 · Cited by 45
The association between exposure to environmental factors and the occurrence of attention-deficit/hyperactivity disorder (ADHD). A population-based retrospective cohort study
Sáez, M., Barceló, M. A., Farrerons, M., & Casasnovas, G. L. I. (2018) · Environmental Research · doi:10.1016/j.envres.2018.05.009 · Cited by 45
Organophosphate Insecticide Toxicity in Neural Development, Cognition, Behaviour and Degeneration: Insights from Zebrafish
Neylon, J., Fuller, J. N., van der Poel, C., Church, J. E., & Dworkin, S. (2022) · Journal of Developmental Biology · doi:10.3390/jdb10040049 · Cited by 44
Attention deficit hyperactivity disorder among children exposed to secondhand smoke: A logistic regression analysis of secondary data
Max, W. B., Sung, H., & Shi, Y. (2012) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2012.10.002 · Cited by 44
Relative Pesticide and Exposure Route Contribution to Aggregate and Cumulative Dose in Young Farmworker Children
Beamer, P. I., Canales, R. A., Ferguson, A., Leckie, J. O., & Bradman, A. (2012) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph9010073 · Cited by 44
Biomonitoring method for neonicotinoid insecticides in urine of non-toilet-trained children using LC-MS/MS
Ueyama, J., Aoi, A., Ueda, Y., Oya, N., Sugiura, Y., Ito, Y., Ebara, T., & Kamijima, M. (2019) · Food Additives & Contaminants Part A · doi:10.1080/19440049.2019.1696020 · Cited by 44
Relationship between Urinary Pesticide Residue Levels and Neurotoxic Symptoms among Women on Farms in the Western Cape, South Africa
Motsoeneng, P. M., & Dalvie, M. A. (2015) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph120606281 · Cited by 43
The Synapse as a Central Target for Neurodevelopmental Susceptibility to Pesticides
Vester, A. I., & Caudle, W. M. (2016) · Toxics · doi:10.3390/toxics4030018 · Cited by 45
Exposure to organophosphorus insecticides and increased risks of health and cancer in US women
Sun, H., Sun, M. L., & Barr, D. B. (2020) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2020.103474 · Cited by 43
Translational outcomes relevant to neurodevelopmental disorders following early life exposure of rats to chlorpyrifos
Berg, E. L., Ching, T. M., Bruun, D. A., Rivera, J. K., Careaga, M., Ellegood, J., Lerch, J. P., Wöhr, M., Lein, P. J., & Silverman, J. L. (2020) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-020-09342-1 · Cited by 43
An educational intervention on the risk perception of pesticides exposure and organophosphate metabolites urinary concentrations in rural school children in Maule Region, Chile
Muñoz-Quezada, M. T., Lucero, B. A., Bradman, A., Steenland, K., Zúñiga-Venegas, L. A., Calafat, A. M., Ospina, M., Iglesias, V., Muñoz, M. P., Buralli, R. J., et al. (2019) · Environmental Research · doi:10.1016/j.envres.2019.108554 · Cited by 42
Astrocytes protect against diazinon- and diazoxon-induced inhibition of neurite outgrowth by regulating neuronal glutathione
Pizzurro, D. M., Dao, K., & Costa, L. G. (2014) · Toxicology · doi:10.1016/j.tox.2014.01.010 · Cited by 41
Potential Diagnostic and Therapeutic Applications of Oligonucleotide Aptamers in Breast Cancer
Wu, X., Shaikh, A. B., Yu, Y., Li, Y., Ni, S., Lü, A., & Zhang, G. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091851 · Cited by 42
Pesticide Exposure and Child Neurodevelopment: Summary and Implications
Liu, J., & Schelar, E. (2012) · Workplace Health & Safety · doi:10.3928/21650799-20120426-73 · Cited by 41
Diazinon and diazoxon impair the ability of astrocytes to foster neurite outgrowth in primary hippocampal neurons
Pizzurro, D., Dao, K., & Costa, L. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.11.023 · Cited by 40
Exposure of C. elegans eggs to a glyphosate-containing herbicide leads to abnormal neuronal morphology
McVey, K. A., Snapp, I. B., Johnson, M. B., Negga, R., Pressley, A. S., & Fitsanakis, V. A. (2016) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2016.03.002 · Cited by 41
Antimicrobial and Antiinsectan Phenolic Metabolites of Dalea searlsiae
Belofsky, G., Aronica, M., Foss, E., Diamond, J., Santana, F., Darley, J., Dowd, P. F., Coleman, C. M., & Ferreira, D. (2014) · Journal of Natural Products · doi:10.1021/np401083g · Cited by 40
Decreased Reelin Expression and Organophosphate Pesticide Exposure Alters Mouse Behaviour and Brain Morphology
Mullen, B. R., Khialeeva, E., Hoffman, D. B., Ghiani, C. A., & Carpenter, E. M. (2012) · ASN NEURO · doi:10.1042/an20120060 · Cited by 41
Maternal Biomarkers of Acetaminophen Use and Offspring Attention Deficit Hyperactivity Disorder
Ji, Y.-L., Riley, A., Lee, L.-C., Hong, X., Wang, G.-Y., Tsai, H.-J., Mueller, N., Pearson, C., Thermitus, J., Panjwani, A., et al. (2018) · Brain Science · doi:10.3390/brainsci8070127 · Cited by 35
Residential proximity to greenhouse crops and pesticide exposure (via acetylcholinesterase activity) assessed from childhood through adolescence
Suarez-Lopez, J. R., Nazeeh, N., Kayser, G., Suárez-Torres, J., Checkoway, H., López-Paredes, D., Jacobs, D. R., & de la Cruz, F. (2020) · Environmental Research · doi:10.1016/j.envres.2020.109728 · Cited by 39
Organic Agriculture Supports Biodiversity and Sustainable Food Production
Underwood, T., McCullum-Gómez, C., Harmon, A. H., & Roberts, S. (2011) · Journal of Hunger & Environmental Nutrition · doi:10.1080/19320248.2011.627301 · Cited by 38
Characterization of organophosphate pesticides in urine and home environment dust in an agricultural community
Tamaro, C. M., Smith, M. N., Workman, T. W., Griffith, W. C., Thompson, B., & Faustman, E. M. (2017) · Biomarkers · doi:10.1080/1354750x.2017.1395080 · Cited by 38
Assessing new dimensions of attentional functions in children prenatally exposed to environmental contaminants using an adapted Posner paradigm
Ethier, A.-A., Muckle, G., Jacobson, S. W., Ayotte, P., Jacobson, J. L., & Saint‐Amour, D. (2015) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2015.07.005 · Cited by 37
Characterizing exposures and neurobehavioral performance in Egyptian adolescent pesticide applicators
Rohlman, D. S., Ismail, A. A., Rasoul, G. A., Lasarev, M. R., Hendy, O. M., & Olson, J. R. (2014) · Metabolic Brain Disease · doi:10.1007/s11011-014-9565-9 · Cited by 40
Organophosphorus Pesticides Induce Cytokine Release from Differentiated Human THP1 Cells
Proskocil, B. J., Grodzki, A. C., Jacoby, D. B., Lein, P. J., & Fryer, A. D. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0257oc · Cited by 37
Association Between Exposure to Pesticides and ADHD or Autism Spectrum Disorder: A Systematic Review of the Literature
Tessari, L., Angriman, M., Díaz‐Román, A., Zhang, J., Conca, A., & Cortese, S. (2020) · Journal of Attention Disorders · doi:10.1177/1087054720940402 · Cited by 37
Associations between pesticide mixtures applied near home during pregnancy and early childhood with adolescent behavioral and emotional problems in the CHAMACOS study
Hyland, C., Bradshaw, P. T., Gunier, R. B., Mora, A. M., Kogut, K. R., Deardorff, J., Sagiv, S. K., Bradman, A., & Eskenazi, B. (2021) · Environmental Epidemiology · doi:10.1097/ee9.0000000000000150 · Cited by 35
Association between urinary biomarkers of exposure to organophosphate insecticides and serum reproductive hormones in men from NHANES 1999–2002
Omoike, O. E., Lewis, R. C., & Meeker, J. D. (2015) · Reproductive Toxicology · doi:10.1016/j.reprotox.2015.04.005 · Cited by 37
Evaluation of Pesticide Residues Occurrence in Random Samples of Organic Fruits and Vegetables Marketed in Poland
Kazimierczak, R., Średnicka-Tober, D., Golba, J., Nowacka, A., Hołodyńska-Kulas, A., Kopczyńska, K., Góralska-Walczak, R., & Gnusowski, B. (2022) · Foods · doi:10.3390/foods11131963 · Cited by 37
PURE: A web-based decision support system to evaluate pesticide environmental risk for sustainable pest management practices in California
Zhan, Y., & Zhang, M. (2012) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2012.05.019 · Cited by 36
Children's Environmental Health in Agricultural Settings
Karr, C. J. (2012) · Journal of Agromedicine · doi:10.1080/1059924x.2012.658009 · Cited by 36
Urinary concentrations of organophosphorus insecticide metabolites in Japanese workers
Ueyama, J., Saito, I., Kondo, T., Taki, T., Kimata, A., Saito, S., Ito, Y., Murata, K., Iwata, T., Gotoh, M., et al. (2012) · Chemosphere · doi:10.1016/j.chemosphere.2012.02.048 · Cited by 34
Assessing Diet as a Modifiable Risk Factor for Pesticide Exposure
Oates, L., & Cohen, M. M. (2011) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph8061792 · Cited by 36
Chronic exposure to chlorpyrifos triggered body weight increase and memory impairment depending on human apoE polymorphisms in a targeted replacement mouse model
Peris‐Sampedro, F., Basaure, P., Reverte, I., Cabré, M., Domingo, J. L., & Colomina, M. T. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.03.006 · Cited by 34
Exposure to non-persistent pesticides, BDNF, and behavioral function in adolescent males: Exploring a novel effect biomarker approach.
Rodríguez-Carrillo, A., Cruz, S., Mustieles, V., Suárez, B., Smagulova, F., David, A., Peinado, F., Artacho-Cordón, F., López, L. C., Arrebola, J., et al. (2022) · Environmental Research · doi:10.1016/j.envres.2022.113115 · Cited by 33
Rationale and Design of the PR egnancy and I nfant DE velopment ( PRIDE ) S tudy
van Gelder, M. M. H. J., Bretveld, R. W., Roukema, J., Steenhoek, M., van Drongelen, J., Spaanderman, M. E. A., van Rumpt, D., Zielhuis, G. A., Verhaak, C. M., & Roeleveld, N. (2012) · Paediatric and Perinatal Epidemiology · doi:10.1111/ppe.12023 · Cited by 34
Maternal Chemical and Drug Intolerances: Potential Risk Factors for Autism and Attention Deficit Hyperactivity Disorder (ADHD)
Heilbrun, L. P., Palmer, R. F., Jaén, C. R., Svoboda, M., Perkins, J., & Miller, C. S. (2015) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.2015.04.140192 · Cited by 33
Prenatal exposure to multiple pesticides is associated with auditory brainstem response at 9months in a cohort study of Chinese infants
Sturza, J. S., Silver, M. K., Xu, L., Li, M., Mai, X., Xia, Y., Shao, J., Lozoff, B., & Meeker, J. D. (2016) · Environment International · doi:10.1016/j.envint.2016.04.035 · Cited by 34
Quantitative analysis of organophosphate insecticide metabolites in urine extracted from disposable diapers of toddlers in Japan
Oya, N., Ito, Y., Hioki, K., Asai, Y., Aoi, A., Sugiura, Y., Ueyama, J., Oguri, T., Kato, S., Ebara, T., et al. (2016) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2016.10.009 · Cited by 33
A revised method for determination of dialkylphosphate levels in human urine by solid-phase extraction and liquid chromatography with tandem mass spectrometry: application to human urine samples from Japanese children
Ueyama, J., Saito, I., Takaishi, A., Nomura, H., Inoue, M., Osaka, A., Sugiura, Y., Hayashi, Y., Wakusawa, S., Ogi, H., et al. (2014) · Environmental Health and Preventive Medicine · doi:10.1007/s12199-014-0407-5 · Cited by 33
Systematic mapping of organophosphate contaminant (OPC) research trends between 1990 and 2018
Olisah, C., & Adams, J. B. (2020) · Environmental Geochemistry and Health · doi:10.1007/s10653-020-00594-3 · Cited by 32
Exposición a plaguicidas en Chile y salud poblacional: urgencia para la toma de decisiones
Zúñiga-Venegas, L. A., Saracini, C., Pancetti, F. C., Muñoz-Quezada, M. T., Lucero, B. A., Foerster, C., & Cortés, S. (2020) · Gaceta Sanitaria · doi:10.1016/j.gaceta.2020.04.020 · Cited by 32
Maternal prenatal and child organophosphate pesticide exposures and children's autonomic function
Quirós-Alcalá, L., Alkon, A., Boyce, W. T., Lippert, S. C., Davis, N. V., Bradman, A., Barr, D. B., & Eskenazi, B. (2011) · NeuroToxicology · doi:10.1016/j.neuro.2011.05.017 · Cited by 34
Organophosphates and carbamates
Gupta, R. C., & Milatović, D. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-385926-6.00045-4 · Cited by 32
Postnatal exposure to PFOS, but not PBDE 99, disturb dopaminergic gene transcription in the mouse CNS
Hallgren, S., & Viberg, H. (2015) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2015.11.016 · Cited by 31
Multidimensional Profiling Platforms Reveal Metabolic Dysregulation Caused by Organophosphorus Pesticides
Medina-Cleghorn, D. A., Heslin, A., Morris, P. J., Mulvihill, M. M., & Nomura, D. K. (2013) · ACS Chemical Biology · doi:10.1021/cb400796c · Cited by 30
On the effect of minocycline on the depressive-like behavior of mice repeatedly exposed to malathion: interaction between nitric oxide and cholinergic system
Saravi, S. S. S., Amirkhanloo, R., Arefidoust, A., Yaftian, R., Saravi, S. S. S., Shokrzadeh, M., & Dehpour, A. R. (2015) · Metabolic Brain Disease · doi:10.1007/s11011-015-9764-z · Cited by 30
Neurobiology of Attention Deficit Hyperactivity Disorder
Faraone, S. V., & Radonjić, N. V. (2023) · Springer eBooks · doi:10.1007/978-3-030-42825-9_33-1 · Cited by 33
Analytical approaches for monitoring exposure to organophosphorus and carbamate agents through analysis of protein adducts
Schopfer, L. M., & Lockridge, O. (2012) · Drug Testing and Analysis · doi:10.1002/dta.1325 · Cited by 30
Implications of estimates of residential organophosphate exposure from dialkylphosphates (DAPs) and their relevance to risk
Krieger, R. I., Chen, L., Ginevan, M. E., Watkins, D., Cochran, R. C., Driver, J., & Ross, J. H. (2012) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2012.08.012 · Cited by 30
Brain-derived neurotrophic factor (BDNF): an effect biomarker of neurodevelopment in human biomonitoring programs
Rodríguez‐Carrillo, A., Verheyen, V. J., van Nuijs, A. L. N., Fernández, M. F., & Rémy, S. (2024) · Frontiers in Toxicology · doi:10.3389/ftox.2023.1319788 · Cited by 32
A framework for assessing the impact of chemical exposures on neurodevelopment in ECHO: Opportunities and challenges
Schantz, S. L., Eskenazi, B., Buckley, J. P., Braun, J. M., Sprowles, J. L. N., Bennett, D. H., Cordero, J. F., Frazier, J. A., Lewis, J. L., Hertz‐Picciotto, I., et al. (2020) · Environmental Research · doi:10.1016/j.envres.2020.109709 · Cited by 30
Organophosphate pesticide dose estimation from spot and 24-hr urine samples collected from children in an agricultural community
Hyland, C., Kogut, K. R., Gunier, R. B., Castorina, R., Curl, C. L., Eskenazi, B., & Bradman, A. (2020) · Environment International · doi:10.1016/j.envint.2020.106226 · Cited by 29
Bursting‐bubble flow microextraction combined with gas chromatography to analyze organophosphorus pesticides in aqueous samples
Tazarv, M., Faraji, H., Moghimi, A., & Azizinejad, F. (2021) · Journal of Separation Science · doi:10.1002/jssc.202001213 · Cited by 29
Early childhood exposure to environmental phenols and parabens, phthalates, organophosphate pesticides, and trace elements in association with attention deficit hyperactivity disorder (ADHD) symptoms in the CHARGE study
Oh, J., Kim, K., Kannan, K., Parsons, P. J., Mlodnicka, A., Schmidt, R. J., Schweitzer, J. B., Hertz‐Picciotto, I., & Bennett, D. H. (2024) · Environmental Health · doi:10.1186/s12940-024-01065-3 · Cited by 29
Correlation of pesticide exposure from dietary intake and bio-monitoring: The different sex and socio-economic study of children
Sinha, S. N., & Banda, V. R. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.06.086 · Cited by 29
Towards sustainable society: from materialism to post-materialism
Salonen, A. O., & Åhlberg, M. (2013) · International Journal of Sustainable Society · doi:10.1504/ijssoc.2013.056846 · Cited by 26
Repeated exposure of pyriproxyfen to pregnant female mice causes developmental abnormalities in prenatal pups
Shahid, A., & Saher, M. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-08656-w · Cited by 29
Prevention of Disability in Children: Elevating the Role of Environment
Rauch, S. A., & Lanphear, B. P. (2012) · The Future of Children · doi:10.1353/foc.2012.0006 · Cited by 25
Cancelling pesticide registrations and revoking tolerances: The case of chlorpyrifos
Centner, T. J. (2017) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2017.11.009 · Cited by 26
Dual detection of Malation and Hg (II) by fluorescence switching of graphene quantum dots
Roushani, M., Kohzadi, S., Haghjoo, S., & Azadbakht, A. (2018) · Environmental Nanotechnology Monitoring & Management · doi:10.1016/j.enmm.2018.08.002 · Cited by 26
Low-Dose Sarin Exposure Produces Long Term Changes in Brain Neurochemistry of Mice
Oswal, D. P., Garrett, T. L., Morris, M., & Lucot, J. B. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0896-9 · Cited by 25
Approach to Evaluating and Managing Adult Attention-Deficit/Hyperactivity Disorder in Primary Care
Huang, H. Y., Huang, H., Spottswood, M., & Ghaemi, S. N. (2020) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000248 · Cited by 26
Prenatal and Childhood Exposure to Organophosphate Pesticides and Behavior Problems in Adolescents and Young Adults in the CHAMACOS Study
Sagiv, S. K., Mora, A. M., Rauch, S. A., Kogut, K. R., Hyland, C., Gunier, R. B., Bradman, A., Deardorff, J., & Eskenazi, B. (2023) · Environmental Health Perspectives · doi:10.1289/ehp11380 · Cited by 24
Chlorpyrifos exposure affects fgf8, sox9, and bmp4 expression required for cranial neural crest morphogenesis and chondrogenesis in Xenopus laevis embryos
Tussellino, M., Ronca, R., Carotenuto, R., Pallotta, M. M., Furia, M., & Capriglione, T. (2016) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22057 · Cited by 25
Characterizing the Neurodevelopmental Pesticide Exposome in a Children’s Agricultural Cohort
Bennett, B., Workman, T. W., Smith, M. N., Griffith, W. C., Thompson, B., & Faustman, E. M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17051479 · Cited by 24
Attention-Deficit/Hyperactivity Disorder
Bokor, G., & Anderson, P. (2014) · Journal of Pharmacy Practice · doi:10.1177/0897190014543628 · Cited by 29
Urinary Dialkylphosphate Metabolite Levels in US Adults—National Health and Nutrition Examination Survey 1999–2008
Gillezeau, C. N., Alpert, N., Joshi, P., & Taioli, E. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16234605 · Cited by 23
Characteristics of Exposure of Reproductive-Age Farmworkers in Chiang Mai Province, Thailand, to Organophosphate and Neonicotinoid Insecticides: A Pilot Study
Suwannarin, N., Prapamontol, T., Isobe, T., Nishihama, Y., & Nakayama, S. F. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17217871 · Cited by 26
Recent Applications of Molecularly Imprinted Polymers (MIPs) on Screen-Printed Electrodes for Pesticide Detection
Nageib, A. M., Halim, A. A., Nordin, A. N., & Ali, F. B. (2023) · Journal of Electrochemical Science and Technology · doi:10.33961/jecst.2022.00654 · Cited by 23
Effects of Pesticide Intake on Gut Microbiota and Metabolites in Healthy Adults
Ueyama, J., Hayashi, M., Hirayama, M., Nishiwaki, H., Ito, M., Saito, I., Tsuboi, Y., Isobe, T., & Ohno, K. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20010213 · Cited by 22
Mishandling and exposure of farm workers in Qatar to organophosphate pesticides
Shomar, B., Al‐Saad, K. A., & Nriagu, J. O. (2014) · Environmental Research · doi:10.1016/j.envres.2014.06.010 · Cited by 22
Attention Deficit/Hyperactivity Disorder and Urinary Nonylphenol Levels: A Case-Control Study in Taiwanese Children
Yu, C.-J., Du, J.-C., Chiou, H.-C., Yang, S.-H., Liao, K.-W., Yang, W., Chung, M., Chien, L.-C., B. Hwang, & Chen, M.-L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149558 · Cited by 21
Environmental and Genetic Traffic in the Journey from Sperm to Offspring
Sengupta, P., Dutta, S., Liew, F. F., Dhawan, V., Das, B., Mottola, F., Sláma, P., Rocco, L., & Roychoudhury, S. (2023) · Biomolecules · doi:10.3390/biom13121759 · Cited by 25
Environmental exposure and child health in China
Ding, G., Gao, Y. X., Kan, H., Zeng, Q., Yan, C., Li, F., Jiang, F., Landrigan, P. J., Tian, Y., & Zhang, J. (2024) · Environment International · doi:10.1016/j.envint.2024.108722 · Cited by 21

Authors: Bouchard, M. F., Bellinger, D. C., Wright, R. O., & Weisskopf, M. G.
Affiliations: Université de Montréal (CA)
Environmental Health (GB)
Brigham and Women's Hospital (US)
ORCID: Bouchard, Maryse F.
Wright, Robert O.
Weisskopf, Marc G.
Venue: Pediatrics
Publisher: American Academy of Pediatrics (AAP)
Published: 2010-06-01
Volume: 125
Issue: 6
Pages: e1270-e1277
ISSN: 0031-4005 (ISSN-L)
1098-4275
DOI: 10.1542/peds.2009-3058
PMC: PMC3706632
OpenAlex: W2126941269
Cited by: 457
References: 34
Citations by year: 2026: 10 · 2025: 19 · 2024: 20 · 2023: 25 · 2022: 18 · 2021: 18 · 2020: 33 · 2019: 18 · 2018: 17 · 2017: 33 · 2016: 36 · 2015: 42 · 2014: 36 · 2013: 30 · 2012: 45
FWCI: 50.25
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: PEDIATRICS (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Centers for Disease Control and Prevention
National Institute of Environmental Health Sciences (P42ES016454, P30ES000002, P30-ES00002, K01ES012653, R01ES013744)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Keywords: attention deficit hyperactivity disorder, organophosphorus pesticides, dialkyl phosphate metabolites, urinary biomarkers, pesticide exposure, children, neurodevelopmental disorders
MeSH terms: Adolescent, Attention Deficit Disorder with Hyperactivity, Child, Creatinine, Cross-Sectional Studies, Environmental Exposure, Female, Humans, Male, Nutrition Surveys, Pesticides, Organophosphates, United States, Prevalence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Attention-Deficit/Hyperactivity Disorder and Urinary Metabolites of Organophosphate Pesticides

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks