Cited by 457Pesticide Exposure and ToxicityAttention Deficit Hyperactivity DisorderEffects and risks of endocrine disrupting chemicals

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Attention-Deficit/Hyperactivity Disorder and Urinary Metabolites of Organophosphate Pesticides

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Bouchard, Maryse F., Bellinger, David C., Wright, Robert O., Weisskopf, Marc G.·2010·Pediatrics

DOI 10.1542/peds.2009-3058PMC PMC3706632

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Abstract

OBJECTIVE: The goal was to examine the association between urinary concentrations of dialkyl phosphate metabolites of organophosphates and attention-deficit/hyperactivity disorder (ADHD) in children 8 to 15 years of age. METHODS: Cross-sectional data from the National Health and Nutrition Examination Survey (2000–2004) were available for 1139 children, who were representative of the general US population. A structured interview with a parent was used to ascertain ADHD diagnostic status, on the basis of slightly modified criteria from the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. RESULTS: One hundred nineteen children met the diagnostic criteria for ADHD. Children with higher urinary dialkyl phosphate concentrations, especially dimethyl alkylphosphate (DMAP) concentrations, were more likely to be diagnosed as having ADHD. A 10-fold increase in DMAP concentration was associated with an odds ratio of 1.55 (95% confidence interval: 1.14–2.10), with adjustment for gender, age, race/ethnicity, poverty/income ratio, fasting duration, and urinary creatinine concentration. For the most-commonly detected DMAP metabolite, dimethyl thiophosphate, children with levels higher than the median of detectable concentrations had twice the odds of ADHD (adjusted odds ratio: 1.93 [95% confidence interval: 1.23–3.02]), compared with children with undetectable levels. CONCLUSIONS: These findings support the hypothesis that organophosphate exposure, at levels common among US children, may contribute to ADHD prevalence. Prospective studies are needed to establish whether this association is causal.

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Authors: Bouchard, M. F., Bellinger, D. C., Wright, R. O., & Weisskopf, M. G.
Affiliations: Université de Montréal (CA)
Environmental Health (GB)
Brigham and Women's Hospital (US)
ORCID: Bouchard, Maryse F.
Wright, Robert O.
Weisskopf, Marc G.
Venue: Pediatrics
Publisher: American Academy of Pediatrics (AAP)
Published: 2010-06-01
Volume: 125
Issue: 6
Pages: e1270-e1277
ISSN: 0031-4005 (ISSN-L)
1098-4275
DOI: 10.1542/peds.2009-3058
PMC: PMC3706632
OpenAlex: W2126941269
Cited by: 457
References: 34
Citations by year: 2026: 10 · 2025: 19 · 2024: 20 · 2023: 25 · 2022: 18 · 2021: 18 · 2020: 33 · 2019: 18 · 2018: 17 · 2017: 33 · 2016: 36 · 2015: 42 · 2014: 36 · 2013: 30 · 2012: 45
FWCI: 50.25
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: PEDIATRICS (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Centers for Disease Control and Prevention
National Institute of Environmental Health Sciences (P42ES016454, P30ES000002, P30-ES00002, K01ES012653, R01ES013744)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Keywords: attention deficit hyperactivity disorder, organophosphorus pesticides, dialkyl phosphate metabolites, urinary biomarkers, pesticide exposure, children, neurodevelopmental disorders
MeSH terms: Adolescent, Attention Deficit Disorder with Hyperactivity, Child, Creatinine, Cross-Sectional Studies, Environmental Exposure, Female, Humans, Male, Nutrition Surveys, Pesticides, Organophosphates, United States, Prevalence

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Attention-Deficit/Hyperactivity Disorder and Urinary Metabolites of Organophosphate Pesticides

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