The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Patent Ductus Arteriosus of the Preterm Infant
Open accessAbstract
A persistently patent ductus arteriosus (PDA) in preterm infants can have significant clinical consequences, particularly during the recovery period from respiratory distress syndrome. With improvement of ventilation and oxygenation, the pulmonary vascular resistance decreases early and rapidly, especially in very immature infants with extremely low birth weight (<1000 g). Subsequently, the left-to-right shunt through the ductus arteriosus (DA) is augmented, thereby increasing pulmonary blood flow, which leads to pulmonary edema and overall worsening of cardiopulmonary status. Prolonged ventilation, with the potential risks of volutrauma, barotrauma, and hyperoxygenation, is strongly associated with the development and severity of bronchopulmonary dysplasia/chronic lung disease. Substantial left-to-right shunting through the ductus may also increase the risk of intraventricular hemorrhage, necrotizing enterocolitis, and death. Postnatal ductal closure is regulated by exposure to oxygen and vasodilators; the ensuing vascular responses, mediated by potassium channels, voltage-gated calcium channels, mitochondrial-derived reactive oxygen species, and endothelin 1, depend on gestational age. Platelets are recruited to the luminal aspect of the DA during closure and probably promote thrombotic sealing of the constricted DA. Currently, it is unclear whether and when a conservative, pharmacologic, or surgical approach for PDA closure may be advantageous. Furthermore, it is unknown if prophylactic and/or symptomatic PDA therapy will cause substantive improvements in outcome. In this article we review the mechanisms underlying DA closure, risk factors and comorbidities of significant DA shunting, and current clinical evidence and areas of uncertainty in the diagnosis and treatment of PDA of the preterm infant.
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Cited by
Retinopathy of prematurity: a review of risk factors and their clinical significance
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Bronchopulmonary dysplasia: A review of pathogenesis and pathophysiology
Kalikkot Thekkeveedu, R., Guaman, M. C., & Shivanna, B. (2017) · Respiratory Medicine · doi:10.1016/j.rmed.2017.10.014 · Cited by 409
Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy
Binet, F., Cagnone, G., Crespo-Garcia, S., Hata, M., Neault, M., Dejda, A., Wilson, A. M., Buscarlet, M., Mawambo, G. T., Howard, J. P., et al. (2020) · Science · doi:10.1126/science.aay5356 · Cited by 283
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Backer, C. L., Eltayeb, O., Mongé, M. C., Mazwi, M. L., & Costello, J. M. (2016) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000000786 · Cited by 13
Metadata
- Authors
- Hamrick, S. E. G., & Hansmann, G.
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2010-05-01
- Volume
- 125
- Issue
- 5
- Pages
- 1020-1030
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W2112825912
- Cited by
- 543
- References
- 58
- FWCI
- 19.04
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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