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Neonatal Jaundice, Autism, and Other Disorders of Psychological Development
Abstract
OBJECTIVES: The goals were to study the association between neonatal jaundice and disorders of psychological development in a national, population-based cohort and to study whether gestational age, parity, and season of birth influenced that association. METHODS: A population-based, follow-up study of all children born alive in Denmark between 1994 and 2004 (N = 733 826) was performed, with data collected from 4 national registers. Survival analysis was used to calculate hazard ratios (HRs). RESULTS: Exposure to jaundice in neonates was associated with increased risk of disorders of psychological development for children born at term. The excess risk of developing a disorder in the spectrum of psychological development disorders after exposure to jaundice as a neonate was between 56% (HR: 1.56 [95% confidence interval [CI]: 1.05–2.30]) and 88% (HR: 1.88 [95% CI: 1.17–3.02]). The excess risk of infantile autism was 67% (HR: 1.67 [95% CI: 1.03–2.71]). This risk for infantile autism was higher if the child was conceived by a parous woman (HR: 2.71 [95% CI: 1.57–4.66]) or was born between October and March (HR: 2.21 [95% CI: 1.24–3.94]). The risk for infantile autism disappeared if the child was conceived by a primiparous woman (HR: 0.58 [95% CI: 0.18–1.83]) or was born between April and September (HR: 1.02 [95% CI: 0.41–2.50]). Similar risk patterns were found for the whole spectrum of autistic disorders. CONCLUSIONS: Neonatal jaundice in children born at term is associated with disorders of psychological development. Parity and season of birth seem to play important roles.
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“March birth as a risk factor for autism has also been reported by several studies from Canada [92], Denmark [80,88], the US [85] and Israel [87].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [80]
In the citing paper
“In contrast, Maimburg et al. (2010) reported increased risk for infantile autism in those born in winter (October to March) [80].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [80]
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Self-citation
Metadata
- Authors
- Maimburg, R. D., Bech, B. H., Væth, M., Møller-Madsen, B., & Olsen, J.
- Affiliations
- Departments of Epidemiology and
- Aarhus University (DK)
- Orthopedic Surgery, Aarhus University Hospital, Aarhus, Denmark; and
- University of California, Los Angeles (US)
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2010-11-01
- Volume
- 126
- Issue
- 5
- Pages
- 872-878
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W2155816875
- Cited by
- 115
- References
- 35
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 7 · 2022: 7 · 2021: 9 · 2020: 9 · 2019: 8 · 2018: 7 · 2017: 8 · 2016: 6 · 2015: 10 · 2014: 13 · 2013: 7 · 2012: 8
- FWCI
- 7.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- PEDIATRICS (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal Health and Biochemistry
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- neonatal jaundice, infantile autism, autism spectrum disorder, gestational age, parity, season of birth, term birth, primiparity, birth cohort
- MeSH terms
- Adult, Birth Weight, Child, Developmental Disabilities, Child Development Disorders, Pervasive, Child, Preschool, Cross-Sectional Studies, Denmark, Female, Follow-Up Studies, Gestational Age, Humans, Infant, Infant, Newborn, Jaundice, Neonatal, Male, Intellectual Disability, Parity, Pregnancy, Registries, Risk Factors, Seasons, Causality, Proportional Hazards Models
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