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Cited by 294Autism Spectrum Disorder ResearchMaternal Mental Health During Pregnancy and PostpartumFamily and Disability Support Research

Pre‐, peri‐ and neonatal risk factors for autism

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GUINCHAT, VINCENT, THORSEN, POUL, LAURENT, CLAUDINE, CANS, CHRISTINE, BODEAU, NICOLAS, COHEN, DAVID·2012·Acta Obstetricia et Gynecologica Scandinavica
DOI 10.1111/j.1600-0412.2011.01325.x
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Abstract

Objective. To identify pre‐, peri‐ and neonatal risk factors for pervasive developmental disorders (PDD). Methods. We searched the Medline database through March 2011 for relevant case–control and population‐based studies on pre‐, peri‐ and neonatal hazards related to PDD, including autism. We identified 85 studies for this review. Data were extracted systematically and organized according to risk factors related to family history, pregnancy, gestational age, delivery, birth milestones and the neonate's condition at birth. Results. During the prenatal period, risk factors for PDD were advanced maternal or paternal ages, being firstborn vs. third or later, maternal prenatal medication use and mother's status as foreign born. During the perinatal and neonatal periods, the risk factors for PDD were preterm birth, breech presentation, planned cesarean section, low Apgar scores, hyperbilirubinemia, birth defect and a birthweight small for gestational age. The influence of maternal pre‐eclampsia, diabetes, vomiting, infections and stress during pregnancy requires further study in order to determine risk for PDD. Discussion. Despite evidence for the association of some pre‐, peri‐ and neonatal risk factors associated with PDD, it remains unclear whether these risks are causal or play a secondary role in shaping clinical expression in individuals with genetic vulnerability. A plausible hypothsesis is that improvements in obstetric and neonatal management have led to an increased rate of survivors with pre‐existing brain damage. Given the variety of risk factors, we propose that future studies should investigate combinations of multiple factors, rather than focusing on a single factor.

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  • Guinchat et al. pointed to three factors associated positively with the development of AD: prematurity (the risk for autism increased with the severity of preterm birth), abnormal presentation in general and breech presentation in particular, and planned cesarean section.

    “During the perinatal period, Guinchat et al. (75) pointed to three factors associated positively with the development of AD: prematurity (the risk for autism increased with the severity of preterm birth), abnormal presentation in general and breech presentation in particular, and planned cesarean section.”

    From Gene × Environment Interactions in Autism Spectrum Disorders: Role of Epigenetic Mechanisms (2014) · cites this paper as [75]

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Authors
GUINCHAT, V., THORSEN, P., LAURENT, C., CANS, C., BODEAU, N., & COHEN, D.
Affiliations
  • Pitié-Salpêtrière Hospital (FR)
  • Kolding Hospital (DK)
Corresponding author
GUINCHAT, VINCENT
ORCID
Venue
Acta Obstetricia et Gynecologica Scandinavica
Publisher
Wiley
Published
2012-02-21
Volume
91
Issue
3
Pages
287-300
ISSN
  • 0001-6349 (ISSN-L)
  • 1600-0412
DOI
10.1111/j.1600-0412.2011.01325.x
OpenAlex
W1901504499
Cited by
294
References
12
Citations by year
2026: 4 · 2025: 14 · 2024: 15 · 2023: 25 · 2022: 29 · 2021: 17 · 2020: 23 · 2019: 13 · 2018: 30 · 2017: 22 · 2016: 22 · 2015: 24 · 2014: 25 · 2013: 22 · 2012: 8
FWCI
1.52
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Acta Obstetricia Et Gynecologica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
Funders
European Commission
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Social Sciences › Psychology › Clinical Psychology › Family and Disability Support Research
Keywords
autism spectrum disorder, pervasive developmental disorders, risk factors, prenatal risk factors, perinatal risk factors, neonatal risk factors, advanced parental age, preterm birth, breech presentation, cesarean section, Apgar score, neonatal hyperbilirubinemia, congenital malformations, small for gestational age, preeclampsia, maternal diabetes, maternal infection, maternal stress, obstetric management
MeSH terms
Apgar Score, Birth Weight, Child Development Disorders, Pervasive, Female, Humans, Infant, Newborn, Obstetric Labor Complications, Pregnancy, Pregnancy Complications, Risk Factors, Delivery, Obstetric

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