Clostridium difficile Infection in Infants and Children
Abstract
Infections caused by Clostridium difficile in hospitalized children are increasing. The recent publication of clinical practice guidelines for C difficile infection in adults did not address issues that are specific to children. The purpose of this policy statement is to provide the pediatrician with updated information and recommendations about C difficile infections affecting pediatric patients.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Hypervirulent strains of Clostridium difficile may induce severe symptoms and should be treated with oral metronidazole or vancomycin.
“However, hypervirulent strains may induce severe symptoms and should be treated with oral metronidazole or vancomycin 36.”
From Antibiotic treatment of acute gastroenteritis in children (2018) · cites this paper as [36]
Cites
Cohen, S. H., Gerding, D. N., Johnson, S., Kelly, C. P., Loo, V. G., McDonald, L. C., Pépin, J., & Wilcox, M. H. (2010) · Infection Control and Hospital Epidemiology · doi:10.1086/651706 · Cited by 2,931 · see citing works
Loo, V. G., Poirier, L., Miller, M. A., Oughton, M., Libman, M., Michaud, S., Bourgault, A., Nguyen, T. T., Frenette, C. H., Kelly, M., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051639 · Cited by 1,944 · see citing works
Zar, F. A., Bakkanagari, S. R., Moorthi, K. M. L. S. T., & Davis, M. B. (2007) · Clinical Infectious Diseases · doi:10.1086/519265 · Cited by 1,247 · see citing works
Wenisch, C., Parschalk, B., Hasenhundl, M., Hirschl, A. M., & Graninger, W. B. (1996) · Clinical Infectious Diseases · doi:10.1093/clinids/22.5.813 · Cited by 500 · see citing works
Benno, Y., Sawada, K., & MITSUOKA, T. (1984) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1984.tb00754.x · Cited by 432 · see citing works
Crobach, M. J. T., Dekkers, O. M., Wilcox, M. H., & Kuijper, E. J. (2009) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2009.03098.x · Cited by 409 · see citing works
Viscidi, R. P., Willey, S., & Bartlett, J. G. (1981) · Gastroenterology · doi:10.1016/0016-5085(81)90644-2 · Cited by 404 · see citing works
Kim, J., Smathers, S. A., Prasad, P. A., Leckerman, K. H., Coffin, S. E., & Zaoutis, T. E. (2008) · PEDIATRICS · doi:10.1542/peds.2008-0469 · Cited by 319 · see citing works
Self-citationJangi, S., & LaMont, J. T. (2010) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181d29767 · Cited by 306 · see citing works
&NA; (2006) · The Pediatric Infectious Disease Journal · doi:10.1097/01.inf.0000202057.19407.4d · Cited by 271 · see citing works
Clostridium difficile Infections among Hospitalized Children, United States, 1997–2006
Zilberberg, M. D., Tillotson, G., & McDonald, L. C. (2010) · Emerging infectious diseases · doi:10.3201/eid1604.090680 · Cited by 240 · see citing works
Epidemiology of Clostridium difficile in Infants
Larson, H. E., Barclay, F. E., Honour, P., & Hill, I. D. (1982) · The Journal of Infectious Diseases · doi:10.1093/infdis/146.6.727 · Cited by 215 · see citing works
Clostridium difficile Infection in Hospitalized Children in the United States
Nylund, C. M., Goudie, A., Garza, J. M., Fairbrother, G., & Cohen, M. B. (2011) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpediatrics.2010.282 · Cited by 202 · see citing works
Strategies to Prevent Clostridium difficile Infections in Acute Care Hospitals
Dubberke, E. R., Gerding, D. N., Classen, D. C., Arias, K. M., Podgorny, K., Anderson, D. J., Burstin, H. R., Calfee, D. P., Coffin, S. E., Fraser, V. J., et al. (2008) · Infection Control and Hospital Epidemiology · doi:10.1086/591065 · Cited by 199 · see citing works
Pothoulakis, C., & LaMont, J. T. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.2.g178 · Cited by 175 · see citing works
(2005) · PubMed · Cited by 163 · see citing works
Canadian Nosocomial Infection Surveillance Program.
Riben, P., Wells, G. A., & Trotman, M. (1987) · PubMed · Cited by 125 · see citing works
Russell, G., Kaplan, J., Ferraro, M., & Michelow, I. C. (2010) · PEDIATRICS · doi:10.1542/peds.2009-3363 · Cited by 120 · see citing works
Wullt, M. (2004) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkh278 · Cited by 107 · see citing works
Wilcox, M. H., Planche, T., Fang, F. C., & Gilligan, P. H. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.02028-10 · Cited by 105 · see citing works
Clostridium difficile Infections in Children
Bryant, K. A., & McDonald, L. C. (2009) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e318198c984 · Cited by 83 · see citing works
Luna, R. A., Boyanton, B. L., Mehta, S., Courtney, E. M., Webb, C. R., Revell, P. A., & Versalovic, J. A. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.01983-10 · Cited by 78 · see citing works
Toltzis, P., Kim, J., Dul, M. J., Zoltanski, J., Smathers, S. A., & Zaoutis, T. E. (2009) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2008.10.016 · Cited by 74 · see citing works
Self-citationRole of Clostridium difficile in childhood diarrhea
Cerquetti, M., Luzzi, I., Caprioli, A., Sebastianelli, A., & Mastrantonio, P. (1995) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-199507000-00009 · Cited by 60 · see citing works
HypervirulentClostridium difficileStrains in Hospitalized Patients, Canada1
Mulvey, M. R., Boyd, D. A., Gravel, D., Hutchinson, J., Kelly, S., McGeer, A., MOORE, D. L., Simor, A. E., Suh, K. N., Taylor, G. D., et al. (2010) · Emerging infectious diseases · doi:10.3201/eid1604.091152 · Cited by 54 · see citing works
Clostridium Difficile in Young Children
Vesikari, T., Isolauri, E., Mäki, M., & Grönroos, P. (1984) · Acta Paediatrica · doi:10.1111/j.1651-2227.1984.tb09903.x · Cited by 50 · see citing works
CLOSTRIDIUM DIFFICILE TOXIN IN FAECAL SPECIMENS OF HEALTHY CHILDREN AND CHILDREN WITH DIARRHOEA
Mårdh, P. A., HELIN, I., COLLEEN, I., Öberg, M., & Holst, E. (1982) · Acta Paediatrica · doi:10.1111/j.1651-2227.1982.tb09414.x · Cited by 48 · see citing works
Clostridium difficile in a pediatric outpatient population
Boenning, D. A., FLEISHER, G. R., Campos, J. M., HULKOWER, C. W., & QUINLAN, R. W. (1982) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-198209000-00011 · Cited by 46 · see citing works
Clostridium difficile and its toxin in healthy neonates.
Richardson, S., Alcock, P. A., & Gray, J. A. (1983) · BMJ · doi:10.1136/bmj.287.6396.878 · Cited by 41 · see citing works
Ellis, M. E., Mandal, B. K., Dunbar, E. M., & Bundell, K. R. (1984) · BMJ · doi:10.1136/bmj.288.6416.524 · Cited by 40 · see citing works
Der Patient mit Ornithintranscarbamylasemangel
Schmidt, J. L., Schroth, M. A., Irouschek, A., Birkholz, T., Kurzai, M., Kröber, S., Meisner, M., & Albrecht, S. (2005) · Der Anaesthesist · doi:10.1007/s00101-005-0911-5 · Cited by 23 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Clostridium difficile infection
Smits, W. K., Lyras, D., Lacy, D. B., Wilcox, M. H., & Kuijper, E. J. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.20 · Cited by 886 · see citing works
Better Tests, Better Care: Improved Diagnostics for Infectious Diseases
Caliendo, A. M., Gilbert, D. N., Ginocchio, C. C., Hanson, K. E., May, L. S., Quinn, T. C., Tenover, F. C., Alland, D., Blaschke, A. J., Bonomo, R. A., et al. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit578 · Cited by 639 · see citing works
Crobach, M. J. T., Planche, T., Eckert, C., Barbut, F., Terveer, E. M., Dekkers, O. M., Wilcox, M. H., & Kuijper, E. J. (2016) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2016.03.010 · Cited by 600 · see citing works
Buss, S. N., Leber, A., Chapin, K., Fey, P. D., Bankowski, M. J., Jones, M. K., Rogatcheva, M., Kanack, K. J., & Bourzac, K. M. (2015) · Journal of Clinical Microbiology · doi:10.1128/jcm.02674-14 · Cited by 554 · see citing works
Youngster, I., Sauk, J., Pindar, C., Wilson, R. G., Kaplan, J. L., Smith, M. B., Alm, E. J., Gevers, D., Russell, G. H., & Hohmann, E. L. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu135 · Cited by 467 · see citing works
Burnham, C. D., & Carroll, K. C. (2013) · Clinical Microbiology Reviews · doi:10.1128/cmr.00016-13 · Cited by 424 · see citing works
Probiotics for Prevention and Treatment of Diarrhea
Guandalini, S. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3182257e98 · Cited by 351 · see citing works
Clostridium difficile and the microbiota
Seekatz, A. M., & Young, V. B. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72336 · Cited by 255 · see citing works
The Use of Systemic and Topical Fluoroquinolones
Bradley, J. S., & Jackson, M. A. (2011) · PEDIATRICS · doi:10.1542/peds.2011-1496 · Cited by 223 · see citing works
Self-citationProbiotics for Prevention and Treatment of Diarrhea
Guarino, A., Guandalini, S., & Vecchio, A. L. (2015) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000349 · Cited by 217 · see citing works
Bhinder, G., Allaire, J. M., Garcia, C., Lau, J. T., Chan, J. M., Ryz, N. R., Bosman, E. S., Graef, F. A., Crowley, S. M., Celiberto, L. S., et al. (2017) · Scientific Reports · doi:10.1038/srep45274 · Cited by 178 · see citing works
The Use of Systemic and Topical Fluoroquinolones
Jackson, M. A., Schutze, G. E., Byington, C. L., Maldonado, Y., Barnett, E. D., Campbell, J. D., Davies, H. D., Lynfield, R., Muñoz, F. M., Nolt, D., et al. (2016) · PEDIATRICS · doi:10.1542/peds.2016-2706 · Cited by 171 · see citing works
Self-citationBella, S. D., Sanson, G., Monticelli, J., Zerbato, V., Principe, L., Giuffrè, M., Pipitone, G., & Luzzati, R. (2024) · Clinical Microbiology Reviews · doi:10.1128/cmr.00135-23 · Cited by 178 · see citing works
Breakthroughs in the treatment and prevention of Clostridium difficile infection
Kociolek, L. K., & Gerding, D. N. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.220 · Cited by 147 · see citing works
Antibiotic treatment of acute gastroenteritis in children
Bruzzese, E., Giannattasio, A., & Guarino, A. (2018) · F1000Research · doi:10.12688/f1000research.12328.1 · Cited by 122 · see citing works
“However, hypervirulent strains may induce severe symptoms and should be treated with oral metronidazole or vancomycin 36 .”
BackgroundDavidovics, Z. H., Michail, S. K., Nicholson, M. R., Kociolek, L. K., Pai, N., Hansen, R., Schwerd, T., Maspons, A., Shamir, R., Szajewska, H., et al. (2018) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002205 · Cited by 127 · see citing works
Clostridium difficile Infection Among Children Across Diverse US Geographic Locations
Wendt, J. M., Cohen, J. A., Mu, Y., Dumyati, G. K., Dunn, J. R., Holzbauer, S., Winston, L. G., Johnston, H. L., Meek, J. I., Farley, M. M., et al. (2014) · PEDIATRICS · doi:10.1542/peds.2013-3049 · Cited by 122 · see citing works
Probiotics for the Prevention of Pediatric Antibiotic-Associated Diarrhea
Hayes, S. R., & Vargas, A. J. (2016) · EXPLORE · doi:10.1016/j.explore.2016.08.015 · Cited by 123 · see citing works
How to: diagnose infection caused by Clostridium difficile
Gateau, C., Couturier, J., Coia, J. E., & Barbut, F. (2017) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2017.12.005 · Cited by 121 · see citing works
Clostridioides difficile: diagnosis and treatments
Guery, B. P., Galperine, T. K., & Barbut, F. (2019) · BMJ · doi:10.1136/bmj.l4609 · Cited by 106 · see citing works
Koo, H. L., Van, J. N., Zhao, M., Ye, X., Revell, P. A., Jiang, Z., Grimes, C. Z., Koo, D. C., Lasco, T. M., Kozinetz, C. A., et al. (2014) · Infection Control and Hospital Epidemiology · doi:10.1086/676433 · Cited by 101 · see citing works
Wolf, J., Kalocsai, K., Fortuny, C., Lazăr, Ş., Bosis, S., Korczowski, B., Petit, A., Bradford, D., Croos‐Dabrera, R., Incera, E., et al. (2019) · Clinical Infectious Diseases · doi:10.1093/cid/ciz1149 · Cited by 86 · see citing works
The effects of proton pump inhibitors on the microbiome in young children
Levy, E. I., Hoang, D. M., & Vandenplas, Y. (2020) · Acta Paediatrica · doi:10.1111/apa.15213 · Cited by 84 · see citing works
The role of Clostridium difficile in the paediatric and neonatal gut — a narrative review
Lees, E. A., Miyajima, F., Pirmohamed, M., & Carrol, E. D. (2016) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-016-2639-3 · Cited by 80 · see citing works
Hourigan, S. K., Oliva‐Hemker, M. M., & Hutfless, S. M. (2014) · Digestive Diseases and Sciences · doi:10.1007/s10620-014-3169-4 · Cited by 78 · see citing works
High-resolution profiling of the gut microbiome reveals the extent of Clostridium difficile burden
Daquigan, N., Seekatz, A. M., Greathouse, K. L., Young, V. B., & White, J. R. (2017) · npj Biofilms and Microbiomes · doi:10.1038/s41522-017-0043-0 · Cited by 70 · see citing works
Dominguez, S. R., Dolan, S. A., West, K., Dantes, R., Epson, E. E., Friedman, D., Littlehorn, C. A., Arms, L. E., Walton, K., Servetar, E. M., et al. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu302 · Cited by 69 · see citing works
Detection of 23 Gastrointestinal Pathogens Among Children Who Present With Diarrhea
Stockmann, C. R., Pavia, A. T., Graham, B., Vaughn, M., Crisp, R., Poritz, M. A., Thatcher, S. A., Korgenski, E. K., Barney, T., Daly, J. A., et al. (2016) · Journal of the Pediatric Infectious Diseases Society · doi:10.1093/jpids/piw020 · Cited by 69 · see citing works
Intestinal Inflammatory Biomarkers and Outcome in Pediatric Clostridium difficile Infections
Feghaly, R. E. E., Stauber, J. L., Tarr, P. I., & Haslam, D. B. (2013) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2013.07.029 · Cited by 67 · see citing works
Hourigan, S. K., Chirumamilla, S. R., Ross, T. L., Golub, J. E., Rabizadeh, S., Saeed, S. A., Elson, C. O., Kelly, C. P., Carroll, K. C., Oliva‐Hemker, M. M., et al. (2013) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000435434.53871.36 · Cited by 64 · see citing works
Association of Clostridium difficile Infections with Acid Suppression Medications in Children
Nylund, C. M., Eide, M. B., & Gorman, G. H. (2014) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2014.06.062 · Cited by 60 · see citing works
The Epidemiology of Clostridium difficile Infection in Japan: A Systematic Review
Riley, T. V., & Kimura, T. (2018) · Infectious Diseases and Therapy · doi:10.1007/s40121-018-0186-1 · Cited by 58 · see citing works
Song, L., Zhao, M., Duffy, D. C., Hansen, J., Shields, K. S., Wungjiranirun, M., Chen, X., Xu, H. J., Leffler, D. A., Sambol, S. P., et al. (2015) · Journal of Clinical Microbiology · doi:10.1128/jcm.01334-15 · Cited by 56 · see citing works
Clostridium Difficile Infection in Children
Borali, E., & Giacomo, C. D. (2016) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001264 · Cited by 55 · see citing works
Fecal microbiota transplantation in children: a brief review
Hourigan, S. K., & Oliva‐Hemker, M. M. (2016) · Pediatric Research · doi:10.1038/pr.2016.48 · Cited by 53 · see citing works
Valiente, E., Bouché, L., Hitchen, P. G., Faulds‐Pain, A., Songane, M., Dawson, L. F., Donahue, E. H., Stabler, R. A., Panico, M., Morris, H. R., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.749523 · Cited by 53 · see citing works
Madden, G. R., Weinstein, R. A., & Sifri, C. D. (2018) · Infection Control and Hospital Epidemiology · doi:10.1017/ice.2017.278 · Cited by 52 · see citing works
Clostridium difficile Infection in Special High-Risk Populations
Cózar-Llistó, A., Ramos, A., & Cobo, J. (2016) · Infectious Diseases and Therapy · doi:10.1007/s40121-016-0124-z · Cited by 50 · see citing works
Tschudin‐Sutter, S., Tamma, P. D., Naegeli, A. N., Speck, K. A., Milstone, A. M., & Perl, T. M. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit581 · Cited by 49 · see citing works
Diagnosis of Clostridium difficile Infections in Children
Antonara, S., & Leber, A. L. (2016) · Journal of Clinical Microbiology · doi:10.1128/jcm.03014-15 · Cited by 49 · see citing works
Clostridium difficileinfection in children: a comprehensive review
Pant, C., Deshpande, A., Altaf, M. A., Minocha, A., & Sferra, T. J. (2013) · Current Medical Research and Opinion · doi:10.1185/03007995.2013.803058 · Cited by 48 · see citing works
Deng, J., Luo, X., Wang, R., Jiang, L., Ding, X., Hao, W., Peng, Y., Jiang, C.-H., Yu, N., & Che, X. (2015) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2015.07.024 · Cited by 45 · see citing works
Ardura, M. I., Toussi, S. S., Siegel, J. D., Lu, Y., Bousvaros, A., & Crandall, W. (2016) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001188 · Cited by 45 · see citing works
Walia, R., Garg, S., Song, Y., Girotra, M., Cuffari, C., Fricke, W. F., & Dutta, S. (2014) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000495 · Cited by 44 · see citing works
Caniza, M. A., ODIO, C. M., Mukkada, S. T., González, M. L., Ceppi, F., Chaisavaneeyakorn, S., Apiwattanakul, N., Howard, S. C., Conter, V., & Bonilla, M. (2015) · Expert Review of Hematology · doi:10.1586/17474086.2015.1071186 · Cited by 43 · see citing works
Clostridium difficile Infection
Gerding, D. N., & Young, V. B. (2015) · Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases · doi:10.1016/b978-1-4557-4801-3.00245-9 · Cited by 44 · see citing works
Barbut, F., Day, N., Bouée, S., Youssouf, A., Grandvoinnet, L., Lalande, V., Couturier, J., & Eckert, C. (2019) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2018.12.024 · Cited by 42 · see citing works
Pollock, N. R. (2015) · Journal of Clinical Microbiology · doi:10.1128/jcm.02419-15 · Cited by 40 · see citing works
Chung, N., Wang, S., Shen, C., Kuo, F.-C., Ho, T., Hsiung, C. A., Mu, J., Wu, F., Huang, L., Huang, Y., et al. (2017) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2017.07.015 · Cited by 40 · see citing works
Diorio, C. J., Robinson, P. D., Ammann, R. A., Castagnola, E., Erickson, K., Esbenshade, A. J., Fisher, B. T., Haeusler, G. M., Kuczynski, S., Lehrnbecher, T., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.18.00407 · Cited by 40 · see citing works
Current and future applications of fecal microbiota transplantation for children
Chen, C.-C., & Chiu, C. (2021) · Biomedical Journal · doi:10.1016/j.bj.2021.11.004 · Cited by 41 · see citing works
Spinler, J. K., Ross, C. L., & Savidge, T. (2016) · Anaerobe · doi:10.1016/j.anaerobe.2016.05.007 · Cited by 39 · see citing works
Epidemiology and Risk Factors for Community Associated Clostridioides difficile in Children
Miranda-Katz, M., Parmar, D. D., Dang, R., Alabaster, A. L., & Greenhow, T. L. (2020) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2020.02.005 · Cited by 39 · see citing works
O’Gorman, M. A., Michaels, M. G., Kaplan, S. L., Otley, A. R., Kociolek, L. K., Hoffenberg, E. J., Kim, K. S., Nachman, S., Pfefferkorn, M. D., Sentongo, T. A. S., et al. (2017) · Journal of the Pediatric Infectious Diseases Society · doi:10.1093/jpids/pix037 · Cited by 38 · see citing works
Diagnostic Guidance for C. difficile Infections
Crobach, M. J. T., Baktash, A., Duszenko, N., & Kuijper, E. J. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-72799-8_3 · Cited by 37 · see citing works
Further analysis reveals new gut microbiome markers of type 2 diabetes mellitus
Wang, X., Xu, X., & Xia, Y. (2016) · Antonie van Leeuwenhoek · doi:10.1007/s10482-016-0805-3 · Cited by 35 · see citing works
Nicholson, M. R., Freswick, P. N., Pentima, M. C. D., Wang, L., Edwards, K. M., Wilson, G. J., & Talbot, T. R. (2017) · Infection Control and Hospital Epidemiology · doi:10.1017/ice.2017.16 · Cited by 35 · see citing works
Self-citationHuertas‐Díaz, L., Kyhnau, R., Ingribelli, E., Bunešová, V., Li, Q., Sasaki, M., Lauener, R. P., Roduit, C., Frei, R., CK‐CARE Study Group, et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2241209 · Cited by 34 · see citing works
Asensio, Á., Bella, S. D., Vecchio, A. L., Grau, S., Hart, W. M., Isidoro, B., Scotto, R., Petrosillo, N., Watt, M., & Nazir, J. (2015) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2015.05.013 · Cited by 34 · see citing works
Jimenez, J., Drees, M. L., Loveridge‐Lenza, B., Eppes, S. C., & del Rosario, J. F. (2015) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000790 · Cited by 34 · see citing works
Clostridium difficile Infection in Pediatric Inflammatory Bowel Disease
Hourigan, S. K., Sears, C. L., & Oliva‐Hemker, M. M. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000666 · Cited by 34 · see citing works
Kim, A., Chang, J. Y., Shin, S., Yi, H., Moon, J. S., Ko, J. S., & Oh, S. (2017) · Journal of Korean Medical Science · doi:10.3346/jkms.2017.32.3.465 · Cited by 34 · see citing works
McFarland, L. V. (2013) · World Journal of Meta-Analysis · doi:10.13105/wjma.v1.i3.102 · Cited by 33 · see citing works
Feghaly, R. E. E., Stauber, J. L., Tarr, P. I., & Haslam, D. B. (2013) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3182a3202f · Cited by 33 · see citing works
Predictors of First Recurrence of Clostridium difficile Infections in Children
Tschudin‐Sutter, S., Tamma, P. D., Milstone, A. M., & Perl, T. M. (2013) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000000108 · Cited by 33 · see citing works
Fareed, S., Sarode, N., Stewart, F. J., Malik, A., Laghaie, E., Khizer, S., Yan, F., Pratte, Z. A., Lewis, J. D., & Immergluck, L. C. (2018) · PeerJ · doi:10.7717/peerj.4663 · Cited by 32 · see citing works
How to: Clostridioides difficile infection in children
Krůtová, M., de Meij, T. G. J., Fitzpatrick, F., Drew, R. J., Wilcox, M. H., & Kuijper, E. J. (2022) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2022.03.001 · Cited by 32 · see citing works
de Graaf, H., Pai, S., Burns, D. A., Karas, J. A., Enoch, D., & Faust, S. N. (2015) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-015-2367-0 · Cited by 32 · see citing works
Community-acquired Clostridium difficile infection in children: A retrospective study
Borali, E., Ortisi, G., Moretti, C., Stacul, E. F., Lipreri, R., Gesu, G. P., & Giacomo, C. D. (2015) · Digestive and Liver Disease · doi:10.1016/j.dld.2015.06.002 · Cited by 31 · see citing works
Antimicrobial treatment of diarrhea/acute gastroenteritis in children
Cohen, R., Raymond, J., & Gendrel, D. (2017) · Archives de Pédiatrie · doi:10.1016/s0929-693x(17)30515-8 · Cited by 30 · see citing works
Kociolek, L. K., Gerding, D. N., Osmolski, J. R., Patel, S. J., Snydman, D. R., McDermott, L. A., & Hecht, D. W. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00714-16 · Cited by 30 · see citing works
Chronic diarrhoea in children: A practical algorithm‐based approach
Shankar, S., & Rosenbaum, J. (2020) · Journal of Paediatrics and Child Health · doi:10.1111/jpc.14986 · Cited by 33 · see citing works
Sammons, J. S., Gerber, J. S., Tamma, P. D., Sandora, T. J., Beekmann, S. E., Polgreen, P. M., & Hersh, A. L. (2013) · Journal of the Pediatric Infectious Diseases Society · doi:10.1093/jpids/pit065 · Cited by 30 · see citing works
Pitfalls in Diagnosis of Pediatric Clostridium difficile Infection
Sammons, J. S., & Toltzis, P. (2015) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2015.05.010 · Cited by 29 · see citing works
Kociolek, L. K., Bovee, M., Carter, D., Ciolino, J. D., Patel, R., O'Donnell, A., Rupp, A., Zheng, X., Shulman, S. T., & Patel, S. (2016) · Journal of the Pediatric Infectious Diseases Society · doi:10.1093/jpids/piw027 · Cited by 29 · see citing works
Salamonowicz, M., Ociepa, T., Frączkiewicz, J., Szmydki‐Baran, A., Matysiak, M. J., Czyźewski, K., Wysocki, M. S., Gałązka, P., Zalas‐Więcek, P., Irga‐Jaworska, N., et al. (2018) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-018-3316-5 · Cited by 29 · see citing works
Acid-Suppressing Agents and Risk for Clostridium difficile Infection in Pediatric Patients
Brown, K. E., Knoderer, C. A., Nichols, K. R., & Crumby, A. S. (2015) · Clinical Pediatrics · doi:10.1177/0009922815569201 · Cited by 28 · see citing works
Updated Management Guidelines for Clostridioides difficile in Paediatrics
Gnocchi, M., Gagliardi, M., Gismondi, P., Gaiani, F., Angelis, G. L. D., & Esposito, S. (2020) · Pathogens · doi:10.3390/pathogens9040291 · Cited by 28 · see citing works
A critical appraisal of probiotics (as drugs or food supplements) in gastrointestinal diseases
Passariello, A., Agricole, P., & Malfertheiner, P. (2014) · Current Medical Research and Opinion · doi:10.1185/03007995.2014.898138 · Cited by 27 · see citing works
Grover, T. R., Pallotto, E. K., Brozanski, B. S., Piazza, A., Chuo, J., Moran, S., McClead, R. E., Mingrone, T., Morelli, L., & Smith, J. R. (2015) · The Journal of Perinatal & Neonatal Nursing · doi:10.1097/jpn.0000000000000102 · Cited by 27 · see citing works
Gawrońska, A., Banasiuk, M., Lachowicz, D., Pituch, H. M., Albrecht, P., & Banaszkiewicz, A. (2017) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000001249 · Cited by 25 · see citing works
Dunn, A. N., Radakovich, N., Ancker, J. S., Donskey, C. J., & Deshpande, A. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa152 · Cited by 25 · see citing works
CaJacob, N., & Cohen, M. B. (2016) · Pediatrics in Review · doi:10.1542/pir.2015-0099 · Cited by 23 · see citing works
Clostridium difficile Colitis Prevention and Treatment
Dinleyici, M., & Vandenplas, Y. (2019) · Advances in experimental medicine and biology · doi:10.1007/5584_2018_322 · Cited by 24 · see citing works
Clostridium difficilein Children: To Treat or Not to Treat?
Shim, J. O. (2014) · Pediatric Gastroenterology Hepatology & Nutrition · doi:10.5223/pghn.2014.17.2.80 · Cited by 24 · see citing works
The good bugs: the use of probiotics in pediatrics
Sansotta, N., Peroni, D. G., Romano, S. L., Rugiano, A., Vuilleumier, P., & Baviera, G. (2019) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000808 · Cited by 23 · see citing works
Clostridium difficile infections in young infants: Case presentations and literature review
Kuiper, G., van Prehn, J., Ang, W., Kneepkens, C. M. F., van der Schoor, S., & de Meij, T. G. J. (2017) · IDCases · doi:10.1016/j.idcr.2017.07.005 · Cited by 23 · see citing works
The molecular basis of Clostridium difficile disease and host response
Feghaly, R. E. E., Bangar, H., & Haslam, D. B. (2014) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000131 · Cited by 22 · see citing works
Fisher, B. T., Sammons, J. S., Li, Y., de Blank, P. M. K., Seif, A. E., Huang, Y.-S., Kavčič, M., Klieger, S. B., Harris, T., Torp, K., et al. (2014) · Journal of the Pediatric Infectious Diseases Society · doi:10.1093/jpids/piu008 · Cited by 22 · see citing works
Predictors of Clostridium difficile infections in hospitalized children
Samady, W., Bush, R. A., Pong, A. L., Andrews, A., & Fisher, E. S. (2013) · Journal of Hospital Medicine · doi:10.1002/jhm.2135 · Cited by 22 · see citing works
van Dorp, S. M., Smajlović, E., Knetsch, C. W., Notermans, D. W., de Greeff, S. C., & Kuijper, E. J. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw699 · Cited by 22 · see citing works
The new frontier of diagnostics: Molecular assays and their role in infection prevention and control
Das, S. B., Shibib, D. R., & Vernon, M. O. (2017) · American Journal of Infection Control · doi:10.1016/j.ajic.2016.08.005 · Cited by 22 · see citing works
Safety considerations when managing gastro-esophageal reflux disease in infants
Simon, M., Levy, E. I., & Vandenplas, Y. (2020) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2020.1843630 · Cited by 21 · see citing works
New Developments in Rapid Diagnostic Testing for Children
Gonzalez, M. D., & McElvania, E. (2017) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2017.11.006 · Cited by 21 · see citing works
Detection of Clostridioides difficile by Real-time PCR in Young Children Does Not Predict Disease
Pahud, B. A., Hassan, F., Harrison, C. J., Halasa, N., Chappell, J. D., Englund, J. A., Klein, E. J., Szilagyi, P. G., Weinberg, G. A., Sherman, A., et al. (2020) · Hospital Pediatrics · doi:10.1542/hpeds.2020-0012 · Cited by 21 · see citing works
Fecal microbiota transplantation for recurrent Clostridium difficile infection in children
Chen, B., Avinashi, V., & Dobson, S. (2017) · Journal of Infection · doi:10.1016/s0163-4453(17)30202-5 · Cited by 19 · see citing works
Optimizing the Laboratory Diagnosis of Clostridium difficile Infection
Gilligan, P. H. (2015) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2015.02.003 · Cited by 19 · see citing works
Vecchio, A. L., Lancella, L., Tagliabue, C., Giacomo, C. D., Garazzino, S., Mainetti, M., Cursi, L., Borali, E., Vita, M. V. D., Boccuzzi, E., et al. (2016) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-016-2793-7 · Cited by 19 · see citing works
DuPont, H. L., & Salge, M. H. (2023) · Antibiotics · doi:10.3390/antibiotics12111617 · Cited by 19 · see citing works
Klatte, J. M., Selvarangan, R., Jackson, M. A., & Myers, A. (2016) · Hospital Pediatrics · doi:10.1542/hpeds.2015-0116 · Cited by 18 · see citing works
Self-citation
- Authors
- COMMITTEE ON INFECTIOUS DISEASES, Schutze, G. E., Willoughby, R. E., Brady, M. T., Byington, C. L., Davies, H. D., Edwards, K. M., Glode, M. P., Jackson, M. A., Keyserling, H. L., Maldonado, Y. A., Murray, D. L., Orenstein, W. A., & Zaoutis, T. E.
- ORCID
- Venue
- PEDIATRICS
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2013-01-01
- Volume
- 131
- Issue
- 1
- Pages
- 196-200
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W1763257557
- Cited by
- 256
- References
- 31
- Citations by year
- 2026: 15 · 2025: 5 · 2024: 6 · 2023: 10 · 2022: 12 · 2021: 17 · 2020: 17 · 2019: 18 · 2018: 21 · 2017: 28 · 2016: 31 · 2015: 29 · 2014: 28 · 2013: 17
- FWCI
- 16.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- PEDIATRICS (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
- Keywords
- Clostridium difficile infection, pediatric infection, hospitalized children, infants, infection control, antimicrobial stewardship
- MeSH terms
- Academies and Institutes, Child, Clostridium Infections, Hand Disinfection, Health Policy, Humans, Infant, Pediatrics, Clostridioides difficile
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review