The DOI matches its Crossref record; 48 of the 51 references it cites were found in a registry or an index.
Long-Term Outcomes of Adolescents With Juvenile-Onset Fibromyalgia in Early Adulthood
Open accessAbstract
OBJECTIVE: This prospective longitudinal study examined the long-term physical and psychosocial outcomes of adolescents with juvenile-onset fibromyalgia (JFM), compared with healthy control subjects, into early adulthood. METHODS: Adolescent patients with JFM initially seen at a pediatric rheumatology clinic (n = 94) and age- and gender-matched healthy control subjects (n = 33) completed online measures of demographic characteristics, pain, physical functioning, mood symptoms, and health care utilization at ∼6 years’ follow-up (mean age: 21 years). A standard in-person tender-point examination was conducted. RESULTS: Patients with JFM had significantly higher pain (P < .001), poorer physical function (P < .001), greater anxiety (P < .001) and depressive symptoms (P < .001), and more medical visits (P < .001)than control subjects. The majority (>80%) of JFM patients continued to experience fibromyalgia symptoms into early adulthood, and 51.1% of the JFM sample met American College of Rheumatology criteria for adult fibromyalgia at follow-up. Patients with JFM were more likely than control subjects to be married and less likely to obtain a college education. CONCLUSIONS: Adolescent patients with JFM have a high likelihood of continued fibromyalgia symptoms into young adulthood. Those who met criteria for fibromyalgia in adulthood exhibited the highest levels of physical and emotional impairment. Emerging differences in educational attainment and marital status were also found in the JFM group. JFM is likely to be a long-term condition for many patients, and this study for the first time describes the wide-ranging impact of JFM on a variety of physical and psychosocial outcomes that seem to diverge from their same-age peers.
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“Frequently, symptoms sustain into adulthood, carrying a significant risk of long-term impairment, reduced probability of obtaining a higher education and a high use of health care costs [9–13].”
From Feasibility of group-based acceptance and commitment therapy for adolescents (AHEAD) with multiple functional somatic syndromes: A pilot study (2020) · cites this paper as [9]
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“and are less likely to obtain a college education.9”
From Comparing group-based acceptance and commitment therapy (ACT) with enhanced usual care for adolescents with functional somatic syndromes: A study protocol for a randomised trial (2016) · cites this paper as [9]
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“A substantial proportion show continuity of functional symptoms into adulthood9–11”
From Comparing group-based acceptance and commitment therapy (ACT) with enhanced usual care for adolescents with functional somatic syndromes: A study protocol for a randomised trial (2016) · cites this paper as [9]
Experimental — accuracy not yet measuredIn the citing paper
“In at least a subset of youth with JPFS, pain is associated with significant and enduring impairment in the ability to participate in usual activities and maintain positive well-being [4–7].”
From Pain, functional disability, and their Association in Juvenile Fibromyalgia Compared to other pediatric rheumatic diseases (2019) · cites this paper as [6]
In the citing paper
“Youth with JPFS often are likely to have comorbid symptoms of anxiety and depression, which can further augment pain perception and problems with functioning and quality of life [6].”
From Pain, functional disability, and their Association in Juvenile Fibromyalgia Compared to other pediatric rheumatic diseases (2019) · cites this paper as [6]
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Cited by
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Nociplastic pain: towards an understanding of prevalent pain conditions
Fitzcharles, M.-A., Cohen, S. P., Clauw, D. J., Littlejohn, G., Usui, C., & Häuser, W. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00392-5 · Cited by 1,253
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“FM in adolescents is associated with significant impairment in physical function and lower perceived health status compared with peers.(98,101) There is often peer-related discrimination with resulting unpopularity, isolation, and school absenteeism.”
BackgroundSelf-citationPalermo, T. M., Law, E. F., Fales, J., Bromberg, M. H., Jessen-Fiddick, T., & Tai, G. (2016) · Pain · doi:10.1097/j.pain.0000000000000348 · Cited by 244
Self-citationThe anxiodepressive comorbidity in chronic pain
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“Apart from genetic factors, long-term outcome of adolescents with juvenile fibromyalgia showed that environmental factors such as educational attainment and marital status also highly contributed to the physical and emotional impairment in adulthood [87] (Fig.”
BackgroundPhysical activity for paediatric rheumatic diseases: standing up against old paradigms
Gualano, B., Bonfá, E., Pereira, R. M. R., & Silva, C. A. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.75 · Cited by 100
Metadata
- Authors
- Kashikar-Zuck, S., Cunningham, N., Sil, S., Bromberg, M. H., Lynch-Jordan, A. M., Strotman, D., Peugh, J., Noll, J., Ting, T. V., Powers, S. W., Lovell, D. J., & Arnold, L. M.
- Affiliations
- Divisions of Behavioral Medicine and Clinical Psychology and
- Pennsylvania State University (US)
- Cincinnati Children's Hospital Medical Center (US)
- University of Cincinnati (US)
- ORCID
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2014-03-01
- Volume
- 133
- Issue
- 3
- Pages
- e592-e600
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- PMC
- PMC3934334
- OpenAlex
- W2044719167
- Cited by
- 135
- References
- 51
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 7 · 2023: 8 · 2022: 9 · 2021: 21 · 2020: 11 · 2019: 9 · 2018: 10 · 2017: 12 · 2016: 15 · 2015: 11 · 2014: 5
- FWCI
- 10.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- PEDIATRICS (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (UL1TR001425)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR054842, K24AR056687)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Pain Management Techniques
- Keywords
- fibromyalgia, adolescents, early adulthood, long-term outcomes, chronic pain, physical function, anxiety, depressive symptoms, health care utilization, educational attainment, marital status, transition to adult care
- MeSH terms
- Adolescent, Age Factors, Child, Depression, Female, Fibromyalgia, Follow-Up Studies, Humans, Male, Pain Measurement, Prospective Studies, Socioeconomic Factors, Time Factors, Cohort Studies, Treatment Outcome, Young Adult
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