Cited by 106Fibromyalgia and Chronic Fatigue Syndrome ResearchPsychosomatic Disorders and Their TreatmentsPediatric Pain Management Techniques

Juvenile fibromyalgia: current status of research and future developments

Open access
Kashikar-Zuck, Susmita, Ting, Tracy V.·2014·Nature Reviews Rheumatology

Abstract

Juvenile-onset fibromyalgia (JFM) is a poorly understood chronic pain condition most commonly affecting adolescent girls. The condition is characterized by widespread musculoskeletal pain and other associated symptoms, including fatigue, nonrestorative sleep, headaches, irritable bowel symptoms, dysautonomia and mood disorders such as anxiety and/or depression. In the past few years, there has been a greater focus on understanding JFM in adolescents. Research studies have provided insight into the clinical characteristics of this condition and its effect on both short-term and long-term psychosocial and physical functioning. The importance of early and effective intervention is being recognized, as research has shown that symptoms of JFM tend to persist and do not resolve over time as was previously believed. Efforts to improve treatments for JFM are underway, and new evidence strongly points to the potential benefits of cognitive-behavioural therapy on improving mood and daily functioning. Research into pharmacotherapy and other nonpharmacological options is in progress. Advancements in the understanding of adult fibromyalgia have paved the way for future studies on diagnosis, assessment and management of JFM. This Review focuses on our current knowledge of the condition, provides an update of the latest research advances, and highlights areas for further study.

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Crossref · 10.1038/nrrheum.2013.177

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  • Prevalence rates of FSS vary considerably due to differences in case definitions, assessment instruments and study populations.

    “Prevalence rates vary considerably due to differences in case definitions, assessment instruments and study populations.1–3”

    From Comparing group-based acceptance and commitment therapy (ACT) with enhanced usual care for adolescents with functional somatic syndromes: A study protocol for a randomised trial (2016) · cites this paper as [2]

    The Introduction (page unavailable) gives a range of 2.1–6.1% for juvenile fibromyalgia in schoolchildren and describes competing classification criteria. It does not attribute variation in prevalence to assessment instruments or study populations, and it addresses juvenile fibromyalgia rather than functional somatic symptoms (FSS) generally. (LLM, conf=0.83)

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Authors
Kashikar-Zuck, S., & Ting, T. V.
Affiliations
Cincinnati Children's Hospital Medical Center (US)
Venue
Nature Reviews Rheumatology
Published
2013-11-26
Volume
10
Issue
2
Pages
89-96
ISSN
  • 1759-4790 (ISSN-L)
  • 1759-4804
OpenAlex
W2047802536
Cited by
106
References
119
Citations by year
2026: 8 · 2025: 6 · 2024: 22 · 2023: 8 · 2022: 10 · 2021: 7 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 9 · 2016: 9 · 2015: 5 · 2014: 6
FWCI
0.91
Type
journal article
Language
en
Open access
Locations
  • Nature Reviews Rheumatology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (UL1TR000077)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (K24AR056687)
  • National Center for Advancing Translational Sciences
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Pain Management Techniques
Keywords
chronic pain, adolescents, chronic widespread pain, fatigue, non-restorative sleep, autonomic dysfunction, mood disorders, cognitive behavioral therapy, pharmacotherapy, non-pharmacological treatment, pathophysiology, prognosis, psychosocial functioning, early intervention
MeSH terms
Adolescent, Drug Therapy, Exercise Therapy, Female, Fibromyalgia, Humans, Male, Self Care, Cognitive Behavioral Therapy, Biomedical Research

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