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Cited by 119LGBTQ Health, Identity, and PolicyHormonal and reproductive studiesSexual Differentiation and Disorders

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Cross-Sex Hormones and Metabolic Parameters in Adolescents With Gender Dysphoria

Jarin, Jason, Pine-Twaddell, Elyse, Trotman, Gylynthia, Stevens, Jaime, Conard, Lee Ann, Tefera, Eshetu, Gomez-Lobo, Veronica·2017·Pediatrics
DOI 10.1542/peds.2016-3173
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Abstract

BACKGROUND AND OBJECTIVES: The Endocrine Society states that adolescents with gender dysphoria may start cross-sex hormones. The goal of this study was to identify patterns in metabolic parameters in transgender adolescents receiving cross-sex hormones. METHODS: Data from adolescents aged 14 to 25 years seen in 1 of 4 clinical sites between 2008 and 2014 were retrospectively analyzed. Subjects were divided into affirmed male (female-to-male) patients taking testosterone and affirmed female (male-to-female) patients taking estrogen. Previously recorded measurements of blood pressure, BMI, testosterone, estradiol, prolactin, lipids, electrolytes, liver function tests, hemoglobin/hematocrit, and hemoglobin A1c were reviewed. These values were obtained from before the start of therapy, at 1 to 3 months after initiation, at 4 to 6 months, and at 6 months and beyond. Repeated measures analysis of variance models were used to evaluate changes over time. RESULTS: One hunderd and sixteen adolescents were included (72 female-to-male subjects and 44 male-to-female subjects). Of the 72 subjects taking testosterone, a significant increase in hemoglobin/hematocrit levels and BMI, as well as a decrease in high-density lipoprotein level, was recorded at each visit. No significant changes in any other parameter tested were found. Of the 44 subjects taking estrogen, no statistically significant changes were noted in the measured metabolic parameters. CONCLUSIONS: Testosterone use was associated with increased hemoglobin and hematocrit, increased BMI, and lowered high-density lipoprotein levels; estrogen was associated with lower testosterone and alanine aminotransferase levels. Otherwise, cross-sex hormone administration in adolescents was not associated with significant differences in the selected metabolic parameters over time.

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Metadata

Authors
Jarin, J., Pine-Twaddell, E., Trotman, G., Stevens, J., Conard, L. A., Tefera, E., & Gomez-Lobo, V.
Affiliations
  • The University of Texas Southwestern Medical Center (US)
  • University of Maryland, Baltimore (US)
  • Cincinnati Children's Hospital Medical Center (US)
  • MedStar Health Research Institute (US)
Corresponding author
Jarin, Jason
ORCID
Venue
Pediatrics
Publisher
American Academy of Pediatrics (AAP)
Published
2017-04-06
Volume
139
Issue
5
Pages
e20163173
ISSN
  • 0031-4005 (ISSN-L)
  • 1098-4275
DOI
10.1542/peds.2016-3173
OpenAlex
W2604605537
Cited by
119
References
19
Citations by year
2026: 2 · 2025: 10 · 2024: 12 · 2023: 10 · 2022: 15 · 2021: 25 · 2020: 16 · 2019: 15 · 2018: 12 · 2017: 2
FWCI
17.61
Type
journal article
Language
en
Open access
closed
Locations
  • PEDIATRICS (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › LGBTQ Health, Identity, and Policy
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords
gender dysphoria, transgender youth, cross-sex hormones, testosterone, estrogen, metabolic parameters, hemoglobin, hematocrit, body mass index, high-density lipoprotein, alanine aminotransferase, liver function tests, prolactin, blood pressure, electrolytes
MeSH terms
Gender Dysphoria, Adolescent, Adult, Alanine Transaminase, Female, Hematocrit, Glycated Hemoglobin, Humans, Cholesterol, HDL, Male, Retrospective Studies, Gonadal Steroid Hormones, Testosterone, Body Mass Index, Young Adult

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