IODIDE GOITER IN THE NEWBORN
Abstract
A hyperthyroid mother, treated with potassium iodide, gave birth to a baby with an enormous goiter. The infant, although hypothyroid, had massive cardiomegaly and high output failure due to a shunt across the vessels of the goiter. Administration of thyroid caused shrinkage of the gland and concomitantly the heart became smaller. The infant then developed hyperthyroidism which persisted for several months. The late stage of onset of hyperthyroidism in the infant, the inability to demonstrate LATS in mother or child, and the resemblance to other reported cases of iodide goiter in infancy together indicate that the hyperthyroidism may have been a consequence of the iodide goiter rather than a result of the transmission of LATS from the hyperthyroid mother.
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The fetal thyroid gland is particularly susceptible to the inhibitory effects of excess iodine in the second half of gestation, and fetal goiter can occur with chronic therapy.
“The fetal thyroid gland is particularly susceptible to the inhibitory effects of excess iodine in the second half of gestation, and fetal goiter can occur with chronic therapy (496).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [496]
The risk of iodide therapy to the fetus relates to inhibition of iodine organification via the Wolff-Chaikoff effect.
“The risk of iodide therapy to the fetus relates to inhibition of iodine organification via the Wolff-Chaikoff effect.”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [496]
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“The fetal thyroid gland is particularly susceptible to the inhibitory effects of excess iodine in the second half of gestation, and fetal goiter can occur with chronic therapy (496).”
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“The fetal thyroid gland is particularly susceptible to the inhibitory effects of excess iodine at the end of gestation, and fetal goiter can occur with chronic therapy (298).”
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“The fetal thyroid gland is particularly susceptible to the inhibitory effects of excess iodine at the end of gestation, and fetal goiter can occur with chronic therapy (298).”
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“27 Although Braverman and Ingbar had shown in the early 1960s that the normal adult thyroid in most cases is able to adjust to iodine excess, 28 the mechanism for this adaptation to the Wolff-Chaikoff effect 29 was not known until 1999, when Eng et al showed that iodine excess is associated with a…”
- Authors
- Senior, B., & Chernoff, H. L.
- Affiliations
- Tufts Medical Center (US)
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 1971-03-01
- Volume
- 47
- Issue
- 3
- Pages
- 510-515
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W1920902504
- Cited by
- 28
- References
- 0
- Citations by year
- 2024: 1 · 2023: 1 · 2016: 1 · 2015: 1
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- PEDIATRICS (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Head and Neck Anomalies
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- maternal hyperthyroidism, potassium iodide, cardiomegaly, high-output heart failure, thyroid hormone replacement
- MeSH terms
- Abnormalities, Drug-Induced, Anus, Imperforate, Female, Goiter, Cardiac Catheterization, Cardiomegaly, Heart Septal Defects, Ventricular, Humans, Hyperthyroidism, Infant, Newborn, Infant, Newborn, Diseases, Iodine Isotopes, Male, Maternal-Fetal Exchange, Potassium Iodide, Pregnancy, Pregnancy Complications, Regional Blood Flow, Thyroid Gland, Thyroid Hormones, Thyroxine
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