CoChat
Sign Up
Cited by 385Neonatal and fetal brain pathologyCardiovascular Conditions and TreatmentsInfant Development and Preterm Care

The DOI matches its Crossref record.

Low‐dose indomethacin and prevention of intraventricular hemorrhage: A multicenter randomized trial

Ment, Laura R., Ehrenkranz, Richard A., Duncan, Charles C., Scott, David T., Taylor, Kenneth J.W., Katz, Karol H., Schneider, Karen C., Makuch, Robert W., Oh, William, Vohr, Betty, Philip, Alistair G.S., Allan, Walter·1994·Pediatrics
DOI 10.1542/peds.93.4.543
Open this paper in CoChat — free account

Abstract

OBJECTIVES: Parenchymal involvement of intraventricular hemorrhage (IVH) is a major risk factor for neurodevelopmental handicap in very low birth weight neonates. Previous trials have suggested that indomethacin would lower the incidence and severity of IVH in very low birth weight neonates. METHODS: We enrolled 431 neonates of 600- to 1250-g birth weight with no evidence for IVH at 6 to 11 hours of age in a prospective, randomized, placebo-controlled trial to test the hypothesis that low-dose indomethacin (0.1 mg/kg intravenously at 6 to 12 postnatal hours and every 24 hours for two more doses) would lower the incidence and severity of IVH. Serial cranial ultrasound examinations and echocardiographs were performed. RESULTS: There were no differences in the birth weight, gestational age, sex, Apgar scores, and percent of neonates treated with surfactant between the indomethacin and placebo groups. Within the first 5 days, 25 (12%) indomethacin-treated and 40 (18%) placebo-treated neonates developed IVH (P = .03, trend test). Only one indomethacin-treated patient experienced grade 4 IVH compared with 10 placebo-treated neonates (P = .01). Sixteen indomethacin-treated neonates and 29 control neonates died (P = .08); there was a difference favoring indomethacin with respect to survival time (P = .06). Eighty-six percent of all neonates had a patent ductus arteriosus on the first postnatal day; indomethacin was associated with significant ductal closure by the fifth day of life (P < .001). There were no differences in adverse events attributed to indomethacin between the two treatment groups. CONCLUSIONS: Low-dose prophylactic indomethacin significantly lowers the incidence and severity of IVH, particularly the severe form (grade 4 IVH). In addition, indomethacin closes the patent ductus arteriosus and is not associated with significant adverse drug events in very low birth weight neonates.

Overview

Integrity signals

Registry

Crossref · 10.1542/peds.93.4.543

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Still being checked.

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Ment, L. R., Ehrenkranz, R. A., Duncan, C. C., Scott, D. T., Taylor, K. J. W., Katz, K. H., Schneider, K. C., Makuch, R. W., Oh, W., Vohr, B., Philip, A. G. S., & Allan, W.
Affiliations
Yale University (US)
ORCID
Venue
Pediatrics
Publisher
American Academy of Pediatrics (AAP)
Published
1994-04-01
Volume
93
Issue
4
Pages
543-550
ISSN
  • 0031-4005 (ISSN-L)
  • 1098-4275
DOI
10.1542/peds.93.4.543
OpenAlex
W2149974774
Cited by
385
References
0
Citations by year
2026: 5 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 14 · 2021: 13 · 2020: 9 · 2019: 9 · 2018: 8 · 2017: 10 · 2016: 10 · 2015: 3 · 2014: 10 · 2013: 9 · 2012: 21
FWCI
20.56
Type
journal article
Language
en
Open access
closed
Locations
  • PEDIATRICS (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Neurological Disorders and Stroke (NS-27116, R01NS027116)
  • National Center for Research Resources (RR06022)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Cardiovascular Conditions and Treatments
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
Keywords
indomethacin, intraventricular hemorrhage, very low birth weight infants, prophylaxis, patent ductus arteriosus, ductus arteriosus closure, neonatal survival, adverse drug reactions, nonsteroidal anti-inflammatory drugs
MeSH terms
Cerebral Hemorrhage, Ductus Arteriosus, Patent, Female, Humans, Indomethacin, Infant, Low Birth Weight, Infant, Newborn, Infant, Premature, Male, Prospective Studies, Regression Analysis, Treatment Outcome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review