Cited by 240Lipoproteins and Cardiovascular HealthLipid metabolism and disordersCholesterol and Lipid Metabolism

Hyperlipidemia

Stewart, Jeremy, McCallin, Tracy, Martinez, Julian, Chacko, Sheebu, Yusuf, Shabana·2020·Pediatrics in Review

Abstract

Cardiovascular disease remains the top cause of morbidity and mortality in the United States. Atherosclerotic plaques are known to start in adolescence, and, therefore, young adults can be affected by coronary artery disease. Children with known risk factors, such as genetic predisposition, including familial hyperlipidemias, diabetes, and renal diseases, are at higher risk. With childhood obesity becoming an epidemic in certain parts of the United States, this problem is further highlighted as an important issue affecting children's health. There are unclear recommendations for pediatricians regarding cholesterol screening of pediatric populations, when to initiate hyperlipidemia treatment with statin therapy, and when to refer to a specialist for further management. This article reviews the epidemiology and pathophysiology of hyperlipidemia, recommendations for screening and types of screening, management (including pharmacology), prognosis, and prevention.

Integrity signals

Registry

Crossref · 10.1542/pir.2019-0053

Cites

38 of 38 references verified0 citation errors · 0 not checkable

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Authors
Stewart, J., McCallin, T., Martinez, J., Chacko, S., & Yusuf, S.
Affiliations
Baylor College of Medicine (US)
Venue
Pediatrics in Review
Published
2020-08-01
Volume
41
Issue
8
Pages
393-402
ISSN
  • 0191-9601 (ISSN-L)
  • 1526-3347
OpenAlex
W4232459612
Cited by
239
References
40
Citations by year
2026: 28 · 2025: 56 · 2024: 67 · 2023: 37 · 2022: 38 · 2021: 12
FWCI
4.99
Type
journal article
Language
en
Open access
closed
Locations
  • Pediatrics in Review (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Keywords
hyperlipidemia, childhood obesity, familial hyperlipidemia, cardiovascular disease, atherosclerosis, cholesterol screening, statin therapy, diabetes mellitus, kidney disease, prognosis, prevention
MeSH terms
Adolescent, Child, Combined Modality Therapy, Humans, Hyperlipidemias, Pediatrics, Risk Factors, United States

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