Cited by 240Lipoproteins and Cardiovascular HealthLipid metabolism and disordersCholesterol and Lipid Metabolism

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Hyperlipidemia

Stewart, Jeremy, McCallin, Tracy, Martinez, Julian, Chacko, Sheebu, Yusuf, Shabana·2020·Pediatrics in Review

DOI 10.1542/pir.2019-0053

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Abstract

Cardiovascular disease remains the top cause of morbidity and mortality in the United States. Atherosclerotic plaques are known to start in adolescence, and, therefore, young adults can be affected by coronary artery disease. Children with known risk factors, such as genetic predisposition, including familial hyperlipidemias, diabetes, and renal diseases, are at higher risk. With childhood obesity becoming an epidemic in certain parts of the United States, this problem is further highlighted as an important issue affecting children's health. There are unclear recommendations for pediatricians regarding cholesterol screening of pediatric populations, when to initiate hyperlipidemia treatment with statin therapy, and when to refer to a specialist for further management. This article reviews the epidemiology and pathophysiology of hyperlipidemia, recommendations for screening and types of screening, management (including pharmacology), prognosis, and prevention.

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Authors: Stewart, J., McCallin, T., Martinez, J., Chacko, S., & Yusuf, S.
Affiliations: Baylor College of Medicine (US)
ORCID: Stewart, Jeremy
McCallin, Tracy
Yusuf, Shabana
Venue: Pediatrics in Review
Publisher: American Academy of Pediatrics (AAP)
Published: 2020-08-01
Volume: 41
Issue: 8
Pages: 393-402
ISSN: 0191-9601 (ISSN-L)
1526-3347
DOI: 10.1542/pir.2019-0053
OpenAlex: W4232459612
Cited by: 239
References: 40
Citations by year: 2026: 28 · 2025: 56 · 2024: 67 · 2023: 37 · 2022: 38 · 2021: 12
FWCI: 4.99
Type: journal article
Language: en
Open access: closed
Locations: Pediatrics in Review (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords: hyperlipidemia, childhood obesity, familial hyperlipidemia, cardiovascular disease, atherosclerosis, cholesterol screening, statin therapy, diabetes mellitus, kidney disease, prognosis, prevention
MeSH terms: Adolescent, Child, Combined Modality Therapy, Humans, Hyperlipidemias, Pediatrics, Risk Factors, United States

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