Pharmacological interventions effective in improving exercise capacity in heart failure
Open accessAbstract
Heart failure (HF) is characterised by exercise intolerance, which substantially impairs quality of life (QOL) and prognosis. The aim of this review is to summarise the state of the art on pharmacological interventions that are able to improve exercise capacity in HF. Ivabradine, trimetazidine and intravenous iron are the only drugs included in the European Society of Cardiology HF guidelines that have consistently been shown to positively affect functional capacity in HF. The beneficial effects on HF symptoms, physical performance and QOL using these pharmacological approaches are described.
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A number of treatments ranging from pharmacological such as intravenous iron, device therapies such as cardiac resynchronization therapy, and non-pharmacological options such as aerobic exercise are associated with improved exercise capacity.
“A number of treatments ranging from pharmacological such as intravenous iron, device therapies such as cardiac resynchronization therapy, and non‐pharmacological options such aerobic exercise are associated with improved exercise capacity. 41 , 42 , 43”
From Prioritizing symptom management in the treatment of chronic heart failure (2020) · cites this paper as [41]
Cites
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O. D., et al. (2021) · PubMed · doi:10.1093/eurheartj/ehab670 · Cited by 19,618 · see citing works
Self-citationAhmed, A., Jorna, T., & Bhandari, S. (2016) · The Nephron journals/Nephron journals · doi:10.1159/000447068 · Cited by 11,782 · see citing works
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw128 · Cited by 11,429 · see citing works
Self-citationESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012
Authors/Task Force Members, McMurray, J. J. V., Adamopoulos, S., Anker, S. D., Auricchio, A., Böhm, M., Dickstein, K., Falk, V., Filippatos, G., Fonseca, C., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs104 · Cited by 6,879 · see citing works
Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study
Swedberg, K., Komajda, M., Böhm, M., Borer, J. S., Ford, I., Dubost-Brama, A., Lerebours, G., & Tavazzi, L. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61198-1 · Cited by 2,563 · see citing works
Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency
Anker, S. D., Comin Colet, J., Filippatos, G., Willenheimer, R., Dickstein, K., Drexler, H., Lüscher, T. F., Bart, B., Banasiak, W., Niegowska, J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0908355 · Cited by 2,083 · see citing works
Ponikowski, P. P., van Veldhuisen, D. J., Colet, J. C., Ertl, G., Michel Komajda, N., VIu, M., McDonagh, T. A., Parkhomenko, A. N., Tavazzi, L., Levesque, V., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu385 · Cited by 1,240 · see citing works
Kantor, P. F., Lucien, A., Kozak, R., & Lopaschuk, G. D. (2000) · Circulation Research · doi:10.1161/01.res.86.5.580 · Cited by 817 · see citing works
Piepoli, M. F., Conraads, V. M., Corrà, U., Dickstein, K., Francis, D. P., Jaarsma, T., McMurray, J. J. V., Pieske, B. M., Piotrowicz, E., Schmid, J., et al. (2011) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfr017 · Cited by 748 · see citing works
Iron deficiency in chronic heart failure: an international pooled analysis
Klip, I. T., Comin-Colet, J., Voors, A. A., Ponikowski, P., Enjuanes, C., Banasiak, W., Lok, D. J., Rosentryt, P., Torrens, A., Polonski, L., et al. (2013) · American Heart Journal · doi:10.1016/j.ahj.2013.01.017 · Cited by 736 · see citing works
Current and Potential Therapeutic Strategies for Hemodynamic Cardiorenal Syndrome
Obi, Y., Kim, T. H., Kovesdy, C. P., Amin, A., & Kalantar‐Zadeh, K. (2015) · Cardiorenal Medicine · doi:10.1159/000441283 · Cited by 614 · see citing works
Okonko, D. O., Grzesło, A., Witkowski, T. G., Mandal, A. K. J., Slater, R. M., Roughton, M., Földes, G., Thum, T., Majda, J., Banasiak, W., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.09.036 · Cited by 568 · see citing works
Lewis, G. D., Malhotra, R. K., Hernandez, A. F., McNulty, S. E., Smith, A. L., Felker, G. M., Tang, W. H. W., LaRue, S., Redfield, M. M., Semigran, M. J., et al. (2017) · JAMA · doi:10.1001/jama.2017.5427 · Cited by 478 · see citing works
van Veldhuisen, D. J., Ponikowski, P. P., van der Meer, P., Metra, M., Böhm, M., Doletsky, A., Voors, A. A., Macdougall, I. C., Anker, S. D., Roubert, B., et al. (2017) · Circulation · doi:10.1161/circulationaha.117.027497 · Cited by 422 · see citing works
Toblli, J. E., Lombraña, A., Duarte, P. J., & Gennaro, F. D. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.07.029 · Cited by 415 · see citing works
Anker, S. D., Kirwan, B., van Veldhuisen, D. J., Filippatos, G. S., Colet, J. C., Ruschitzka, F. T., Lüscher, T. F., Arutyunov, G. P., Motro, M., Mori, C., et al. (2017) · European Journal of Heart Failure · doi:10.1002/ejhf.823 · Cited by 411 · see citing works
Disordered Iron Homeostasis in Chronic Heart Failure
Okonko, D. O., Mandal, A. K. J., Missouris, C. G., & Poole-Wilson, P. A. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.04.040 · Cited by 373 · see citing works
Jankowska, E. A., Tkaczyszyn, M., Suchocki, T., Drozd, M., von Haehling, S., Doehner, W., Banasiak, W., Filippatos, G. S., Anker, S. D., & Ponikowski, P. P. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.473 · Cited by 346 · see citing works
Randomised study of effect of ibopamine on survival in patients with advanced severe heart failure
Hampton, J. R., van Veldhuisen, D., Kleber, F. X., Cowley, A., Ardia, A., Block, P., Cortina, A., Cserhalmi, L., Folláth, F., Jensen, G. B., et al. (1997) · The Lancet · doi:10.1016/s0140-6736(96)10488-8 · Cited by 345 · see citing works
Intravenous Iron Alone for the Treatment of Anemia in Patients With Chronic Heart Failure
Bolger, A. P., Bartlett, F. R., Penston, H. S., O’Leary, J., Pollock, N., Kaprielian, R., & Chapman, C. M. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.015 · Cited by 292 · see citing works
Fragasso, G., Palloshi, A., Puccetti, P., Silipigni, C., Rossodivita, A., Pala, M. G., Calori, G., Alfieri, O., & Margonato, A. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.03.060 · Cited by 270 · see citing works
Ekman, I., Chassany, O., Michel Komajda, N., Böhm, M., BORER, J. S., Ford, I., Tavazzi, L., & Swedberg, K. B. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr343 · Cited by 206 · see citing works
Trimetazidine: a meta-analysis of randomised controlled trials in heart failure
Gao, D., Ning, N., Niu, X., Hao, G., & Meng, Z. (2010) · Heart · doi:10.1136/hrt.2010.208751 · Cited by 195 · see citing works
Vitale, C., WAJNGATEN, M., Sposato, B., Gebara, O., Rossini, P. M., Fini, M., Volterrani, M., & Rosano, G. M. C. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.06.034 · Cited by 183 · see citing works
Self-citationPrevalence and Outcomes of Anemia and Hematinic Deficiencies in Patients With Chronic Heart Failure
Cleland, J. G. F., Zhang, J., Pellicori, P., Dicken, B., Dierckx, R., Shoaib, A., Wong, K., Rigby, A. S., Goode, K. M., & Clark, A. L. (2016) · JAMA Cardiology · doi:10.1001/jamacardio.2016.1161 · Cited by 179 · see citing works
Additional Use of Trimetazidine in Patients With Chronic Heart Failure
Zhang, L., Lu, Y., Jiang, H., Zhang, L., Sun, A., Zou, Y., & Ge, J. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.11.027 · Cited by 164 · see citing works
Napoli, P. D., Taccardi, A. A., & Barsotti, A. (2005) · Heart · doi:10.1136/hrt.2003.031310 · Cited by 141 · see citing works
Rosano, G. M. C., Vitale, C., Sposato, B., Mercuro, G. G., & Fini, M. (2003) · Cardiovascular Diabetology · doi:10.1186/1475-2840-2-16 · Cited by 137 · see citing works
Self-citationUsmanov, R. I., Zueva, E. B., Silverberg, D. S., & Shaked, M. (2008) · Journal of Nephrology · doi:10.1093/joneph/21.2.236 · Cited by 130 · see citing works
Volterrani, M., Cice, G., Caminiti, G., Vitale, C., D’Isa, S., Filardi, P. P., Acquistapace, F., Marazzi, G., Fini, M., & Rosano, G. M. C. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.06.098 · Cited by 129 · see citing works
Self-citationPacker, M., The Principal Investigators of the Reflect Study, Narahara, K. A., Elkayam, U., Sullivan, J. M., Pearle, D. L., Massie, B. M., & Creager, M. A. (1993) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(93)90816-j · Cited by 119 · see citing works
Fragasso, G., Rosano, G. M. C., Baek, S. H., Sisakian, H. S., Napoli, P. D., Alberti, L., Calori, G., Kang, S., Sahakyan, L. G., Sanosyan, A., et al. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.09.123 · Cited by 96 · see citing works
Self-citationTrimetazidine improves endothelial dysfunction in chronic heart failure: an antioxidant effect
Belardinelli, R., Solenghi, M., Volpe, L., & Purcaro, A. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm071 · Cited by 85 · see citing works
Sarullo, F. M., Fazio, G., Puccio, D., Fasullo, S., Paterna, S., Novo, S., & Pasquale, P. D. (2010) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248410370326 · Cited by 56 · see citing works
Is Treatment with Trimetazidine Beneficial in Patients with Chronic Heart Failure?
Zhou, X., & Chen, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094660 · Cited by 53 · see citing works
Barré, J., Ledudal, P., Oosterhuis, B., Brakenhoff, J. P. G., Wilkens, G., Sollie, F. A. E., & Tran, D. (2003) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.350 · Cited by 36 · see citing works
Bagriy, A. E., Schukina, E. V., Samoilova, O. V., Pricolota, O. A., Malovichko, S. I., Pricolota, A. V., & Bagriy, E. A. (2015) · Advances in Therapy · doi:10.1007/s12325-015-0185-5 · Cited by 36 · see citing works
Sisakian, H. S., Torgomyan, A., & Barkhudaryan, A. (2007) · Acta Cardiologica · doi:10.2143/ac.62.5.2023413 · Cited by 32 · see citing works
Trimetazidine improves exercise tolerance in patients with ischemic heart disease
Zhao, Y., Peng, L., Luo, Y., Li, S., Zheng, Z., Dong, R., Zhu, J., & Liu, J. (2015) · Herz · doi:10.1007/s00059-015-4392-2 · Cited by 32 · see citing works
Metabolic Modulation: A New Therapeutic Target in Treatment of Heart Failure
Palaniswamy, C., Mellana, W. M., Selvaraj, D. R., & Mohan, D. (2010) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e3181d70453 · Cited by 25 · see citing works
Génissel, P., Chodjania, Y., Démolis, J., Ragueneau, I., & Jaillon, P. (2004) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/bf03190575 · Cited by 19 · see citing works
Trimetazidine Shortens QTc Interval in Patients With Ischemic Heart Failure
Zemljič, G., Bunc, M., & Vrtovec, B. (2009) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248409354601 · Cited by 17 · see citing works
The Role of Ivabradine and Trimetazidine in the New ESC HF Guidelins
Milinković, I., Rosano, G. M. C., Lopatin, Y. M., & Seferovic, P. M. (2016) · Cardiac failure review · doi:10.15420/cfr.2016:13:1 · Cited by 12 · see citing works
Self-citationCardiac and Hemodynamic Benefits: Mode of Action of Ivabradine in Heart Failure
Pereira-Barretto, A. C. (2015) · Advances in Therapy · doi:10.1007/s12325-015-0257-6 · Cited by 10 · see citing works
Rosano, G. M. C., Vitale, C., & Volterrani, M. (2010) · Advances in Therapy · doi:10.1007/s12325-010-0030-9 · Cited by 7 · see citing works
Self-citationPharmacological management of chronic heart failure: old drugs, new drugs and new indications
Lim, W. Y., & Woldman, S. (2013) · British Journal of Hospital Medicine · doi:10.12968/hmed.2013.74.sup2.c18 · Cited by 2 · see citing works
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Self-citation
- Authors
- Vitale, C., Spoletini, I., & Rosano, G. M.
- Affiliations
- IRCCS San Raffaele Roma (IT)
- Venue
- Cardiac failure review
- Publisher
- Radcliffe Medical Media Ltd
- Published
- 2018
- Volume
- 4
- Issue
- 1
- Pages
- 1
- ISSN
- 2057-7540 (ISSN-L)
- PMC
- PMC5971671
- OpenAlex
- W2803764206
- Cited by
- 9
- References
- 47
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 5
- FWCI
- 0.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Cardiac failure review (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart rate and cardiovascular health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- heart failure, exercise capacity, exercise intolerance, pharmacological interventions, ivabradine, trimetazidine, intravenous iron, functional capacity, quality of life, physical performance
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