Side effects of the calcineurin inhibitor, such as new-onset diabetes after kidney transplantation
Open accessAbstract
New-onset diabetes after transplantation (NODAT) is one of the frequent complications following kidney transplantation. Patients were randomized to receive cyclosporine A- or tacrolimus-based immunosuppression. Fasting and oral glucose tolerance tests were performed, and the patients were assigned to one of the following three groups based on the results: normal, impaired fasting glucose/impaired glucose tolerance (IFG/IGT), or NODAT. NODAT developed in 14% of patients receiving cyclosporine A-based immunosuppression and in 26% of patients taking tacrolimus (p = 0.0002). Albumin levels were similar, but uric acid level (p = 0.002) and the age of the recipient (p = 0.003) were significantly different comparing the diabetic and the normal groups. Evaluation of tissue samples revealed that acute cellular rejection (ACR) and interstitial fibrosis/tubular atrophy (IF/TA) were significantly different in the NODAT group. The pathological effect of new-onset diabetes after kidney transplantation can be detected in the morphology of the renal allograft earlier, before the development of any sign of functional impairment.
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Testosterone replacement improves glycemia, dyslipidemia, hepatic steatosis, body composition, and cardiovascular risk.
“testosterone replacement improves glycemia, dyslipidemia, hepatic steatosis, body composition, and CVD risk”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [1571]
The Patients and Methods and Results sections compare cyclosporine-based with tacrolimus-based treatment in kidney transplant recipients and report new-onset diabetes. The Discussion addresses diabetes care and cardiovascular risk, but no passage found in searches for testosterone replacement or androgen therapy addresses their effects on the claimed outcomes. Page numbers were not available. (LLM, conf=0.76)
Experimental — accuracy not yet measuredTestosterone replacement prevents progression from prediabetes to type 2 diabetes.
“and also prevents progression from prediabetes to T2D.1571–1574”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [1571]
The Patients and Methods and Results sections compare cyclosporine- and tacrolimus-based immunosuppression in kidney transplant recipients, including rates of impaired glucose regulation and new-onset diabetes. Searches for testosterone replacement and prevention of progression from prediabetes found no passage addressing that claim. (LLM, conf=0.76)
Experimental — accuracy not yet measured
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Cites
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Flagged first, then by citations
Research works printed but not linked: 1
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Cited by
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Blonde, L., Umpierrez, G. E., Reddy, S. S., McGill, J. B., Berga, S. L., Bush, M., Chandrasekaran, S., DeFronzo, R. A., Einhorn, D., Galindo, R. J., et al. (2022) · Endocrine Practice · doi:10.1016/j.eprac.2022.08.002 · Cited by 507 · see citing works
- Authors
- Borda, B., Lengyel, C., Várkonyi, T., Kemény, É., Ottlakán, A., Kubik, A., Keresztes, C., & Lázár, G.
- Affiliations
- University of Szeged (HU)
- Semmelweis University (HU)
- Venue
- Acta Physiologica Hungarica
- Publisher
- Akademiai Kiado Zrt.
- Published
- 2014-09
- Volume
- 101
- Issue
- 3
- Pages
- 388-394
- ISSN
- 0231-424X (ISSN-L)
- 1588-2683
- OpenAlex
- W2114974207
- Cited by
- 18
- References
- 17
- Citations by year
- 2025: 1 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 2 · 2017: 3 · 2015: 3
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Acta Physiologica Hungarica (publishedVersion)
- PubMed (publishedVersion)
- SZTE Publicatio Repozitórium (University of Szeged) (acceptedVersion, other-oa)
- Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
- Topics
- Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Keywords
- post-transplant diabetes mellitus, kidney transplantation, calcineurin inhibitors, cyclosporine, tacrolimus, immunosuppression, impaired glucose tolerance, impaired fasting glucose, uric acid, acute cellular rejection, interstitial fibrosis and tubular atrophy, renal allograft pathology, transplant complications
- MeSH terms
- Adult, Age Factors, Aged, Atrophy, Biopsy, Blood Glucose, Diabetes Mellitus, Fasting, Female, Fibrosis, Glucose Tolerance Test, Graft Rejection, Humans, Hungary, Immunosuppressive Agents, Kidney, Male, Middle Aged, Risk Factors, Time Factors, Incidence, Kidney Transplantation, Tacrolimus, Cyclosporine, Calcineurin, Calcineurin Inhibitors
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