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Cited by 523

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Case Series of Multisystem Inflammatory Syndrome in Adults Associated with SARS-CoV-2 Infection — United Kingdom and United States, March–August 2020

Open access
Morris, Sapna Bamrah, Schwartz, Noah G., Patel, Pragna, Abbo, Lilian, Beauchamps, Laura, Balan, Shuba, Lee, Ellen H., Paneth-Pollak, Rachel, Geevarughese, Anita, Lash, Maura K., Dorsinville, Marie S., Ballen, Vennus, Eiras, Daniel P., Newton-Cheh, Christopher, Smith, Emer, Robinson, Sara, Stogsdill, Patricia, Lim, Sarah, Fox, Sharon E., Richardson, Gillian, Hand, Julie, Oliver, Nora T., Kofman, Aaron, Bryant, Bobbi, Ende, Zachary, Datta, Deblina, Belay, Ermias, Godfred-Cato, Shana·2020·MMWR. Morbidity and Mortality Weekly Report

Abstract

During the course of the coronavirus disease 2019 (COVID-19) pandemic, reports of a new multisystem inflammatory syndrome in children (MIS-C) have been increasing in Europe and the United States (1-3). Clinical features in children have varied but predominantly include shock, cardiac dysfunction, abdominal pain, and elevated inflammatory markers, including C-reactive protein (CRP), ferritin, D-dimer, and interleukin-6 (1). Since June 2020, several case reports have described a similar syndrome in adults; this review describes in detail nine patients reported to CDC, seven from published case reports, and summarizes the findings in 11 patients described in three case series in peer-reviewed journals (4-6). These 27 patients had cardiovascular, gastrointestinal, dermatologic, and neurologic symptoms without severe respiratory illness and concurrently received positive test results for SARS-CoV-2, the virus that causes COVID-19, by polymerase chain reaction (PCR) or antibody assays indicating recent infection. Reports of these patients highlight the recognition of an illness referred to here as multisystem inflammatory syndrome in adults (MIS-A), the heterogeneity of clinical signs and symptoms, and the role for antibody testing in identifying similar cases among adults. Clinicians and health departments should consider MIS-A in adults with compatible signs and symptoms. These patients might not have positive SARS-CoV-2 PCR or antigen test results, and antibody testing might be needed to confirm previous SARS-CoV-2 infection. Because of the temporal association between MIS-A and SARS-CoV-2 infections, interventions that prevent COVID-19 might prevent MIS-A. Further research is needed to understand the pathogenesis and long-term effects of this newly described condition.

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Metadata

Authors
Morris, S. B., Schwartz, N. G., Patel, P., Abbo, L., Beauchamps, L., Balan, S., Lee, E. H., Paneth-Pollak, R., Geevarughese, A., Lash, M. K., Dorsinville, M. S., Ballen, V., Eiras, D. P., Newton-Cheh, C., Smith, E., Robinson, S., Stogsdill, P., Lim, S., Fox, S. E., Richardson, G., Hand, J., Oliver, N. T., Kofman, A., Bryant, B., Ende, Z., Datta, D., Belay, E., & Godfred-Cato, S.
Venue
MMWR. Morbidity and Mortality Weekly Report
Published
2020-10-09
Volume
69
Issue
40
Pages
1450-1456
ISSN
  • 0149-2195 (ISSN-L)
  • 1545-861X
OpenAlex
W3089911709
Cited by
523
References
9
FWCI
96.52
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Case Series of Multisystem Inflammatory Syndrome in Adults Associated with SARS-CoV-2 Infection — United Kingdom and United States, March–August 2020. https://app.cochat.ai/papers/10.15585/mmwr.mm6940e1
The paper
Morris, S. B., Schwartz, N. G., Patel, P., Abbo, L., Beauchamps, L., Balan, S., Lee, E. H., Paneth-Pollak, R., Geevarughese, A., Lash, M. K., Dorsinville, M. S., Ballen, V., Eiras, D. P., Newton-Cheh, C., Smith, E., Robinson, S., Stogsdill, P., Lim, S., Fox, S. E., . . . Godfred-Cato, S. (2020). Case Series of Multisystem Inflammatory Syndrome in Adults Associated with SARS-CoV-2 Infection — United Kingdom and United States, March–August 2020. MMWR. Morbidity and Mortality Weekly Report. https://doi.org/10.15585/mmwr.mm6940e1

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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