The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Patients With Acute Myocarditis Following mRNA COVID-19 Vaccination
Open accessAbstract
Importance: Vaccine-associated myocarditis is an unusual entity that has been described for the smallpox vaccine, but only anecdotal case reports have been described for other vaccines. Whether COVID-19 vaccination may be linked to the occurrence of myocarditis is unknown. Objective: To describe a group of 7 patients with acute myocarditis over 3 months, 4 of whom had recent messenger RNA (mRNA) COVID-19 vaccination. Design, Setting, and Participants: All patients referred for cardiovascular magnetic resonance imaging at Duke University Medical Center were asked to participate in a prospective outcomes registry. Two searches of the registry database were performed: first, to identify patients with acute myocarditis for the 3-month period between February 1 and April 30 for 2017 through 2021, and second, to identify all patients with possible vaccine-associated myocarditis for the past 20 years. Once patients with possible vaccine-associated myocarditis were identified, data available in the registry were supplemented by additional data collection from the electronic health record and a telephone interview. Exposures: mRNA COVID-19 vaccine. Main Outcomes and Measures: Occurrence of acute myocarditis by cardiovascular magnetic resonance imaging. Results: In the 3-month period between February 1 and April 30, 2021, 7 patients with acute myocarditis were identified, of which 4 occurred within 5 days of COVID-19 vaccination. Three were younger male individuals (age, 23-36 years) and 1 was a 70-year-old female individual. All 4 had received the second dose of an mRNA vaccine (2 received mRNA-1273 [Moderna], and 2 received BNT162b2 [Pfizer]). All presented with severe chest pain, had biomarker evidence of myocardial injury, and were hospitalized. Coincident testing for COVID-19 and respiratory viruses provided no alternative explanation. Cardiac magnetic resonance imaging findings were typical for myocarditis, including regional dysfunction, late gadolinium enhancement, and elevated native T1 and T2. Conclusions and Relevance: In this study, magnetic resonance imaging findings were found to be consistent with acute myocarditis in 7 patients; 4 of whom had preceding COVID-19 vaccination. Further investigation is needed to determine associations of COVID-19 vaccination and myocarditis.
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Schulz-Menger, J., Bluemke, D. A., Bremerich, J., Flamm, S. D., Fogel, M. A., Friedrich, M. G., Kim, R. J., von Knobelsdorff-Brenkenhoff, F., Kramer, C. M., Pennell, D. J., et al. (2013) · Journal of Cardiovascular Magnetic Resonance · doi:10.1186/1532-429x-15-35 · Cited by 2,097
Self-citationStandardized cardiovascular magnetic resonance imaging (CMR) protocols: 2020 update
Kramer, C. M., Barkhausen, J., Bucciarelli-Ducci, C., Flamm, S. D., Kim, R. J., & Nagel, E. (2020) · Journal of Cardiovascular Magnetic Resonance · doi:10.1186/s12968-020-00607-1 · Cited by 1,245
Self-citationMorris, S. B., Schwartz, N. G., Patel, P., Abbo, L., Beauchamps, L., Balan, S., Lee, E. H., Paneth-Pollak, R., Geevarughese, A., Lash, M. K., et al. (2020) · MMWR. Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6940e1 · Cited by 523
Ammirati, E., Cipriani, M., Moro, C., Raineri, C., Pini, D., Sormani, P., Mantovani, R., Varrenti, M., Pedrotti, P., Conca, C., et al. (2018) · Circulation · doi:10.1161/circulationaha.118.035319 · Cited by 452
Eckart, R. E., Love, S. S., Atwood, J. E., Arness, M. K., Cassimatis, D. C., Campbell, C. L., Boyd, S. Y., Murphy, J. G., Swerdlow, D. L., Collins, L. C., et al. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.05.004 · Cited by 178
Engler, R. J. M., Nelson, M. R., Collins Jr., L. C., Spooner, C., Hemann, B. A., Gibbs, B. T., Atwood, J. E., Howard, R. S., Chang, A. S., Cruser, D. L., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0118283 · Cited by 169
Heitner, J. F., Kim, R. J., Kim, H. W., Klem, I., Shah, D. J., Debs, D., Farzaneh‐Far, A., Polsani, V. R., Kim, J. J., Weinsaft, J. W., et al. (2019) · JAMA Cardiology · doi:10.1001/jamacardio.2019.0035 · Cited by 149
Self-citationMyocarditis and pericarditis are rare following live viral vaccinations in adults
Kuntz, J. L., Crane, B., Weinmann, S. A., & Naleway, A. L. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.02.030 · Cited by 62
Kim, Y., Bae, J.-I., Ryoo, S. M., & Kim, W. Y. (2018) · Acute and Critical Care · doi:10.4266/acc.2017.00045 · Cited by 34
Cited by
Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus
Raman, B., Bluemke, D. A., Lüscher, T. F., & Neubauer, S. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac031 · Cited by 650
Myocarditis and Pericarditis After Vaccination for COVID-19
Diaz, G. A., Parsons, G. T., Gering, S. K., Meier, A. R., Hutchinson, I. V., & Robicsek, A. (2021) · JAMA · doi:10.1001/jama.2021.13443 · Cited by 430
Heidecker, B., Dagan, N., Balicer, R., Eriksson, U., Rosano, G., Coats, A., Tschöpe, C., Kelle, S., Poland, G. A., Frustaci, A., et al. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2669 · Cited by 159
Alami, A., Krewski, D., Farhat, N., Mattison, D., Wilson, K., Gravel, C. A., Farrell, P. J., Crispo, J. A. G., Haddad, N., Perez-Lloret, S., et al. (2023) · BMJ Open · doi:10.1136/bmjopen-2022-065687 · Cited by 44
COVID-19 and Myocarditis: Review of Clinical Presentations, Pathogenesis and Management
Lovell, J. P., Division of Cardiology, D. O. M., Čiháková, D., Department of Pathology, J. H. U. O. M., W. Harry Feinstone Department of Molecular Microbiology and Immunology, J. H. U. B. S. O. P. H., Gilotra, N. A., & Division of Cardiology, D. O. M. (2022) · Heart International · doi:10.17925/hi.2022.16.1.20 · Cited by 29
Metadata
- Authors
- Kim, H. W., Jenista, E. R., Wendell, D. C., Azevedo, C. F., Campbell, M. J., Darty, S. N., Parker, M. A., & Kim, R. J.
- Venue
- JAMA Cardiology
- Publisher
- American Medical Association (AMA)
- Published
- 2021-10-01
- Volume
- 6
- Issue
- 10
- Pages
- 1196
- ISSN
- 2380-6583 (ISSN-L)
- OpenAlex
- W3176051599
- Cited by
- 341
- References
- 9
- FWCI
- 48.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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