The DOI matches its Crossref record, with a small difference in title or year; 79 of the 80 references it cites were found in a registry or an index.
Symposium‐in‐Print: Singlet Oxygen Invited Review
Abstract
Singlet oxygen (1O2) is unique amongst reactive oxygen species formed in cells in that it is an excited state molecule with an inherent upper lifetime of 4 micros in water. Whether the lifetime of 1O2 in cells is shortened by reactions with cellular molecules or reaches the inherent maximum value is still unclear. However, even with the maximum lifetime, the diffusion radius is only approximately 220 nm during three lifetimes (approximately 5% 1O2 remaining), much shorter than cellular dimensions indicating that the primary reactions of 1O2 will be subcellularly localized near the site of 1O2 formation. This fact has raised the question of whether spatially resolved cellular responses to 1O2 occur, i.e. whether responses can be initiated by generation and reaction of 1O2 at a particular subcellular location that would not have been produced by 1O2 generation at other subcellular sites. In this paper, we discuss examples of spatially resolved responses initiated by 1O2 as a function of distance from the site of generation of 1O2. Three levels are recognized, namely, a molecular level where the primary oxidation product directly modifies the behavior of a cell, an organelle level where the initial photo-oxidation products initiate mechanisms that are unique to the organelle and the cellular level where mediators diffuse from their site of formation to the target molecules that initiate the response. These examples indicate that, indeed, spatially resolved responses to 'O2 occur in cells.
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“Due to the short lifetime and diffusion distance of singlet oxygen, the site of oxidative damage is in close proximity to the localization of the photosensitizer [13].”
From 5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy (2023) · cites this paper as [13]
In the citing paper
“With high reactivity, singlet oxygen can oxidize various biological substances including proteins, lipids, and nucleic acids, causing tissue oxidative damage.”
From 5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy (2023) · cites this paper as [13]
Citations
Cites
Photodynamic therapy: a new antimicrobial approach to infectious disease?
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Brown, S. B., Brown, E. A., & Walker, I. O. (2004) · The Lancet Oncology · doi:10.1016/s1470-2045(04)01529-3 · Cited by 1,772
Photodynamic antimicrobial chemotherapy (PACT)
WAINWRIGHT, M. S. (1998) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/42.1.13 · Cited by 1,235
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THE PHOTODEGRADATION OF PORPHYRINS IN CELLS CAN BE USED TO ESTIMATE THE LIFETIME OF SINGLET OXYGEN
Moan, J. E., & Berg, K. (1991) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1991.tb03669.x · Cited by 1,010
Rapid Induction of Distinct Stress Responses after the Release of Singlet Oxygen in Arabidopsis[W]
den Camp, R. O., Przybyla, D., Ochsenbein, C., Laloi, C., Kim, C., Danon, A., Wagner, D., Hideg, É., Göbel, C., Feußner, I., et al. (2003) · The Plant Cell · doi:10.1105/tpc.014662 · Cited by 757
The Genetic Basis of Singlet OxygenInduced Stress Responses of Arabidopsis thaliana
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A genetically encoded photosensitizer
Bulina, M. E., Chudakov, D. M., Britanova, O. V., Yanushevich, Y. G., Staroverov, D. B., Chepurnykh, T. V., Merzlyak, E. M., Shkrob, M., Lukyanov, S., & Lukyanov, K. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1175 · Cited by 597
An Update on Photodynamic Therapy Applications
Dougherty, T. J. (2002) · Journal of Clinical Laser Medicine & Surgery · doi:10.1089/104454702753474931 · Cited by 547
Research works printed but not linked: 3
- Ouedraogo G. D., 2002, Photosensitized membrane oxidation leads to remote DNA damage by secondary reactive oxygen species, Free Radical Biol. Med., 33, S421
- Booth L. A., 2002, Can lipid peroxidation of plasma membranes induce DNA strand breaks, Free Radical Biol. Med., 33, S390
- 10.1039/b307576c · DOI
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Sorted by citations
Singlet oxygen: there is indeed something new under the sun
Ogilby, P. R. (2010) · Chemical Society Reviews · doi:10.1039/b926014p · Cited by 1,292
The unique role of nanoparticles in nanomedicine: imaging, drug delivery and therapy
Doane, T. L., & Burda, C. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15260f · Cited by 1,113
Singlet oxygen in plants: production, detoxification and signaling
Triantaphylidès, C., & Havaux, M. (2009) · Trends in Plant Science · doi:10.1016/j.tplants.2009.01.008 · Cited by 715
Singlet Molecular Oxygen Reactions with Nucleic Acids, Lipids, and Proteins
Mascio, P. D., Martinez, G. R., Miyamoto, S., Ronsein, G. E., de Medeiros, M. H. G., & Cadet, J. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00554 · Cited by 674
β-Carotene Is an Important Vitamin A Source for Humans
Grune, T., Lietz, G., Palou, A., Ross, A. C., Stahl, W., Tang, G., Thurnham, D., Yin, S.-A., & Biesalski, H. K. (2010) · The Journal of Nutrition · doi:10.3945/jn.109.119024 · Cited by 587
Metadata
- Authors
- Redmond, R. W., & Kochevar, I. E.
- Affiliations
- Harvard University (US)
- Corresponding author
- Redmond, Robert W.
- Kochevar, Irene E.
- Venue
- Photochemistry and Photobiology
- Publisher
- Wiley
- Published
- 2006-09
- Volume
- 82
- Issue
- 5
- Pages
- 1178-1186
- ISSN
- 0031-8655 (ISSN-L)
- 1751-1097
- OpenAlex
- W2176326379
- Cited by
- 421
- References
- 80
- Citations by year
- 2026: 13 · 2025: 15 · 2024: 19 · 2023: 23 · 2022: 25 · 2021: 36 · 2020: 18 · 2019: 29 · 2018: 29 · 2017: 20 · 2016: 19 · 2015: 25 · 2014: 19 · 2013: 29 · 2012: 21
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Photochemistry and Photobiology (publishedVersion)
- PubMed (publishedVersion)
- BioOne Complete (BioOne) (submittedVersion)
- Funders
- National Cancer Institute (P01CA095227)
- National Institute of General Medical Sciences (R01GM030755)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- singlet oxygen, reactive oxygen species, singlet oxygen lifetime, subcellular localization, photooxidation, mediators
- MeSH terms
- Humans, Kinetics, Light, Mitochondria, Photochemistry, Photochemotherapy, Photosensitizing Agents, Reactive Oxygen Species, Singlet Oxygen, Luminescence
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