The DOI matches its Crossref record; 165 of the 165 references it cites were found in a registry or an index.
Nucleolar Stress: hallmarks, sensing mechanism and diseases
Open accessAbstract
The nucleolus is a prominent subnuclear compartment, where ribosome biosynthesis takes place. Recently, the nucleolus has gained attention for its novel role in the regulation of cellular stress. Nucleolar stress is emerging as a new concept, which is characterized by diverse cellular insult-induced abnormalities in nucleolar structure and function, ultimately leading to activation of p53 or other stress signaling pathways and alterations in cell behavior. Despite a number of comprehensive reviews on this concept, straightforward and clear-cut way criteria for a nucleolar stress state, regarding the factors that elicit this state, the morphological and functional alterations as well as the rationale for p53 activation are still missing. Based on literature of the past two decades, we herein summarize the evolution of the concept and provide hallmarks of nucleolar stress. Along with updated information and thorough discussion of existing confusions in the field, we pay particular attention to the current understanding of the sensing mechanisms, i.e., how stress is integrated by p53. In addition, we propose our own emphasis regarding the role of nucleolar protein NPM1 in the hallmarks of nucleolar stress and sensing mechanisms. Finally, the links of nucleolar stress to human diseases are briefly and selectively introduced.
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Cites
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BackgroundWAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.
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Spatial resolution of cellular senescence dynamics in human colorectal liver metastasis
Garbarino, O., Lambroia, L., Basso, G., Marrella, V., Franceschini, B., Soldani, C., Pasqualini, F., Giuliano, D., Costa, G., Peano, C., et al. (2023) · Aging Cell · doi:10.1111/acel.13853 · Cited by 43
“Gene ontology analysis of eSMCC- related genes identified enrichment of pathways involved in nucleolar stress (Figure 2b and Table S4) (Boulon et al., 2010; Yang et al., 2018).”
BackgroundRole of uL3 in the Crosstalk between Nucleolar Stress and Autophagy in Colon Cancer Cells
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Mapping the invisible chromatin transactions of prophase chromosome remodeling
Samejima, I., Spanos, C., Samejima, K., Rappsilber, J., Kustatscher, G., & Earnshaw, W. C. (2022) · Molecular Cell · doi:10.1016/j.molcel.2021.12.039 · Cited by 21
Metadata
- Authors
- Yang, K., Yang, J., & Yi, J.
- Venue
- Cell Stress
- Publisher
- Shared Science Publishers OG
- Published
- 2018-06-11
- Volume
- 2
- Issue
- 6
- Pages
- 125-140
- ISSN
- 2523-0204 (ISSN-L)
- OpenAlex
- W2806793653
- Cited by
- 283
- References
- 165
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- gold
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